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全反式维甲酸和干扰素-γ协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响

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全反式维甲酸和干扰素-γ协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb200404029

全反式维甲酸和干扰素-γ协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响

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Full title

全反式维甲酸和干扰素-γ协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响

Author / Creator

邓怀慈 , 张晓智 and 张龙

Publisher

西安交通大学第一医院肿瘤放疗科,陕西西安,710061

Journal title

西安交通大学学报(医学版), 2004, Vol.25 (4), p.401-403

Language

Chinese

Formats

Articles

Publication information

Publisher

西安交通大学第一医院肿瘤放疗科,陕西西安,710061

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Scope and Contents

Contents

R739.41; 目的研究全反式维甲酸(ATRA)和干扰素-γ(IFN-γ)联合应用对胶质瘤细胞增殖、凋亡及侵袭力的协同影响.方法 ATRA和 IFN-γ共同处理人胶质瘤细胞系SHG-44,MTT比色法检测细胞增殖能力,流式细胞仪检测瘤细胞周期分布和凋亡率;根据瘤细胞穿过Matrigel胶的能力,检测瘤细胞体外侵袭力;以ATRA、 IFN-γ单独处理的细胞作为对照.结果胶质瘤细胞经ATRA和IFN-γ联合处理后增殖能力下降,凋亡率增加,细胞阻滞于G1期,其侵袭性降低,与单独处理组相比较差异有显著性(P<0.05).结论 ATRA和IFN-γ联合应用具有协同抑制人胶质瘤细胞系SHG-44恶性表型和诱导凋亡的作用.

Alternative Titles

Full title

全反式维甲酸和干扰素-γ协同作用对人胶质瘤细胞系SHG-44增殖、凋亡及侵袭力的影响

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Author / Creator

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Record Identifier

TN_cdi_wanfang_journals_xaykdxxb200404029

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb200404029

Other Identifiers

ISSN

1671-8259

DOI

10.3969/j.issn.1671-8259.2004.04.029

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