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哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响

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哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201004005

哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响

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Full title

哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响

Author / Creator

张玉蓉 , 袁祖贻 and 任延平

Publisher

西安交通大学医学院第一附属医院,老年内科,陕西西安,710061%西安交通大学医学院第一附属医院,心血管内科,陕西西安,710061

Journal title

西安交通大学学报（医学版）, 2010, Vol.31 (4), p.411-414

Language

Chinese

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Articles

Publication information

Publisher

西安交通大学医学院第一附属医院,老年内科,陕西西安,710061%西安交通大学医学院第一附属医院,心血管内科,陕西西安,710061

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Contents

R363.21; 目的 观察哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响.方法 28只SD大鼠随机分为2组,即哇巴因组[27.8μg/(kg·d)哇巴因腹腔注射]和对照组(生理盐水1mL/d腹腔注射),每周测量鼠尾动脉血压,共5周.于第3、5周后分2批处死动物,应用分光光度法测定各组大鼠肾皮质Na+-K+-ATP酶活性,同时采用实时定量PCR(real-time PCR)观察肾皮质中多巴胺D1受体mRNA表达的变化.结果 大鼠腹腔注射哇巴因3周后,两组血压无显著性差异,但哇巴因组大鼠肾皮质Na+-K+-ATP酶活性高于对照组(P<0.01),多巴胺D1受体mRNA表达低于对照组(P<0.01).5周后,哇巴因组大鼠血压与对照组相比有显著性差异(P<0.01)...

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Full title

哇巴因对大鼠肾皮质Na+-K+-ATP酶活性及多巴胺D1受体mRNA表达的影响

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TN_cdi_wanfang_journals_xaykdxxb201004005

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201004005

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ISSN

1671-8259

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