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哮喘大鼠肺内神经生长因子的表达变化及与病理改变的关系

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哮喘大鼠肺内神经生长因子的表达变化及与病理改变的关系

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201201015

哮喘大鼠肺内神经生长因子的表达变化及与病理改变的关系

About this item

Full title

哮喘大鼠肺内神经生长因子的表达变化及与病理改变的关系

Author / Creator

余巍巍 杨新官

Publisher

桂林医学院第一附属医院呼吸内科,广西桂林,541001

Journal title

西安交通大学学报（医学版）, 2012, Vol.33 (1), p.65-67

Language

Chinese

Formats

Articles

Publication information

Publisher

桂林医学院第一附属医院呼吸内科,广西桂林,541001

Subjects

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Scope and Contents

Contents

目的 探讨神经生长因子(nerve growth factor,ngf)致哮喘大鼠肺内病理改变及被拮抗后肺内表达的变化,为哮喘的发病机制和治疗提供理论依据.方法 随机将48只sd大鼠分为:正常对照组、哮喘组和抗ngf干预组,每组均16只.取肺组织在光镜下测量支气管基底膜厚度并计数黏膜下成纤维细胞的数目,he染色观察气道病理改变并测量呼吸道平滑肌厚度；用免疫组化法检测肺组织ngf的表达.结果 哮喘组肺组织ngf表达较对照组明显增强(p＜0.01)；ngf的表达与呼吸道平滑肌厚度有明显相关性；哮喘组呼吸道平滑肌厚度、网状基底膜厚度、黏膜下成纤维细胞数目及ngf的表达均高于对照组和抗ngf干预组(p＜0.05)；抗ngf干预组显著缓解上述变化(p＜0.05).结论 支气管哮喘大鼠气道组织中ngf表...

Alternative Titles

Full title

哮喘大鼠肺内神经生长因子的表达变化及与病理改变的关系

Authors, Artists and Contributors

Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_wanfang_journals_xaykdxxb201201015

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201201015

Other Identifiers

ISSN

1671-8259

DOI

10.3969/j.issn.1671-8259.2012.01.015

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