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骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

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骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201902031

骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

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Full title

骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

Author / Creator

曾辉 , 赵许兵 , 唐成芳 , 周芳 , 左艳萍 and 谢娜

Publisher

西安医学院口腔医学系,陕西西安,710021%西安交通大学口腔医院综合科,陕西西安,710004

Journal title

西安交通大学学报（医学版）, 2019-03, Vol.40 (2), p.328-332

Language

Chinese

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Articles

Publication information

Publisher

西安医学院口腔医学系,陕西西安,710021%西安交通大学口腔医院综合科,陕西西安,710004

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Scope and Contents

Contents

R787; 目的 探讨骨碎补总黄酮对去卵巢大鼠下颌骨结构及血清雌二醇(E2)水平、血清骨保护素/细胞核因子κB受体活化因子配基(OPG/RANKL)平衡的影响.方法 将40只3月龄雌性SD大鼠随机分为假手术组(Sham)、去卵巢模型组(OVX)、骨碎补总黄酮高剂量组(GB-H)、骨碎补总黄酮低剂量组(GB-L)和戊酸雌二醇组(EV).采用摘除大鼠双侧卵巢的方法构建下颌骨骨质疏松模型,给药12周后处死大鼠.截取大鼠下颌磨牙段进行组织切片观察和形态计量学测量,放射免疫法检测血清E2水平,ELISA法检测血清OPG、RANKL水平.结果 与Sham组相比,OVX组大鼠下颌骨呈疏松样改变,E2水平显著降低(P<0.001),OPG和OPG/RANKL比值显著降低(P<0.001,P<0.001).与...

Alternative Titles

Full title

骨碎补总黄酮对去卵巢大鼠下颌骨结构、血清E2及OPG/RANKL的影响

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Record Identifier

TN_cdi_wanfang_journals_xaykdxxb201902031

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201902031

Other Identifiers

ISSN

1671-8259

DOI

10.7652/jdyxb201902031

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