上调miR-24对急性肺损伤幼龄大鼠炎症反应的影响及作用机制
上调miR-24对急性肺损伤幼龄大鼠炎症反应的影响及作用机制
Publication information
Publisher
开封市儿童医院呼吸科,河南开封,475000%河南大学基础医学院免疫教研室,河南开封,475004
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Scope and Contents
Contents
R364.5; 目的 探究微小型RNA-24(microRNA-24,miR-24)对急性肺损伤(acute lung injury,ALI)幼龄大鼠炎症反应的影响及作用机制.方法 将幼龄大鼠分为Control、ALI、ALI+miR-24 mimic mock及ALI+ miR-24 mimic组,利用脂多糖(LPS)建立幼龄大鼠ALI模型.miR-24 mimic mock及ALI+ miR-24 mimic分别处理模型大鼠后,计算大鼠肺组织干湿重比,qRT-PCR检测miR-24的mRNA表达,HE染色观察大鼠肺组织病理变化,Tunel检测肺组织细胞凋亡情况,Western blot检测肺组织中磷酸化核因子κB p65(nuclear factor κB p65,NF-κB p65)、...
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Full title
上调miR-24对急性肺损伤幼龄大鼠炎症反应的影响及作用机制
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Primary Identifiers
Record Identifier
TN_cdi_wanfang_journals_xaykdxxb201905005
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201905005
Other Identifiers
ISSN
1671-8259
DOI
10.7652/jdyxb201905004
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