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莱菔硫烷激动Nrf-2抗炎症改善小鼠肾缺血再灌注损伤

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莱菔硫烷激动Nrf-2抗炎症改善小鼠肾缺血再灌注损伤

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201905007

莱菔硫烷激动Nrf-2抗炎症改善小鼠肾缺血再灌注损伤

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Full title

莱菔硫烷激动Nrf-2抗炎症改善小鼠肾缺血再灌注损伤

Author / Creator

黄霖 , 廖盼丽 and 张炯

Publisher

华中科技大学同济医学院附属武汉儿童医院,武汉市妇幼保健院儿科肾内,湖北武汉430016

Journal title

西安交通大学学报（医学版）, 2019-09, Vol.40 (5), p.696-701

Language

Chinese

Formats

Articles

Publication information

Publisher

华中科技大学同济医学院附属武汉儿童医院,武汉市妇幼保健院儿科肾内,湖北武汉430016

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Scope and Contents

Contents

R331.3; 目的 基于小鼠肾缺血再灌注(ischemia reperfusion injury,IRI)模型探析莱菔硫烷(sulforaphane,SFN)对小鼠肾IRI的作用与机制,为制定肾缺血再灌注的有效干预措施提供实验依据.方法 24只雄性C57小鼠,随机分为4组:假手术对照组(Ctrl)、肾缺血再灌注组(IRI)、莱菔硫烷干预肾缺血再灌注组(IRI+ SFN)、莱菔硫烷单独给药组(SFN).术前24h对SFN处理组小鼠尾静脉注射500 μg/kg SFN.以无创血管夹夹闭小鼠双侧肾蒂45 min建立肾IRI模型,假手术对照组除不夹闭双侧肾蒂外其他操作同上.在各组小鼠恢复肾脏血流灌注24 h以后,收集小鼠全血和肾组织标本进行病理检测.ELISA检测小鼠血清中TNF-α、IL-1β和...

Alternative Titles

Full title

莱菔硫烷激动Nrf-2抗炎症改善小鼠肾缺血再灌注损伤

Authors, Artists and Contributors

Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_wanfang_journals_xaykdxxb201905007

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb201905007

Other Identifiers

ISSN

1671-8259

DOI

10.7652/jdyxb201905006

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