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人脐血间充质干细胞来源的外泌体对早产子代大鼠学习记忆能力及海马的影响

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人脐血间充质干细胞来源的外泌体对早产子代大鼠学习记忆能力及海马的影响

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb202003003

人脐血间充质干细胞来源的外泌体对早产子代大鼠学习记忆能力及海马的影响

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Full title

人脐血间充质干细胞来源的外泌体对早产子代大鼠学习记忆能力及海马的影响

Author / Creator

黄谱 and 宗璐

Publisher

西安交通大学第一附属医院妇产科,陕西西安,710061

Journal title

西安交通大学学报（医学版）, 2020, Vol.41 (3), p.317-332

Language

Chinese

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Articles

Publication information

Publisher

西安交通大学第一附属医院妇产科,陕西西安,710061

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Scope and Contents

Contents

R714.7; 目的 探讨人脐血间充质干细胞(human umbilical cord blood mesenchymal stem cells,Hu-MSCs)来源的外泌体对早产仔鼠神经行为学的影响.方法 采用试剂盒提取法从Hu-MSCs中分离、纯化外泌体并鉴定.45只孕鼠随机分为3组,实验组、脂多糖(lipopolysaccharide,LPS)组和对照组,于孕15日实验组腹腔注射外泌体悬液、LPS组与对照组腹腔注射等量生理盐水溶液;孕17日,实验组、LPS组宫内注射100μL 25μg/μL LPS溶液,对照组宫内注射100μL生理盐水,观察3组孕鼠妊娠结局;仔鼠于生后1月进行Morris水迷宫实验,评价子代空间学习记忆能力的改变,实验后取仔鼠海马组织镜下观察海马病理改变.结果 成功从...

Alternative Titles

Full title

人脐血间充质干细胞来源的外泌体对早产子代大鼠学习记忆能力及海马的影响

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Record Identifier

TN_cdi_wanfang_journals_xaykdxxb202003003

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xaykdxxb202003003

Other Identifiers

ISSN

1671-8259

DOI

10.7652/jdyxb202003002

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