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褪黑素对慢性脑低灌注大鼠脑白质的保护作用

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褪黑素对慢性脑低灌注大鼠脑白质的保护作用

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xdsjjbzz201907006

褪黑素对慢性脑低灌注大鼠脑白质的保护作用

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Full title

褪黑素对慢性脑低灌注大鼠脑白质的保护作用

Author / Creator

李丹丹 , 黄敏莹 , 赵弘轶 , 夏振西 and 黄勇华

Publisher

100700北京,解放军总医院第七医学中心神经内科

Journal title

中国现代神经疾病杂志, 2019-07, Vol.19 (7), p.481-489

Language

Chinese

Formats

Articles

Publication information

Publisher

100700北京,解放军总医院第七医学中心神经内科

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Scope and Contents

Contents

目的 探讨褪黑素对脑小血管病模型大鼠社交行为和脑白质损害的改善作用及其药理学机制.方法 采用双侧颈总动脉结扎法制备慢性脑低灌注模型,44只SD大鼠随机分为假手术组、模型组、褪黑素5 mg/(kg·d)组和10 mg/(kg·d)组(每组各11只),分别以嗅探实验(嗅探时间和穿越次数)评价模型大鼠社交行为、倒置相差荧光显微镜观察胼胝体髓鞘碱性蛋白(MBP)表达水平、透射电子显微镜观察胼胝体白质髓鞘完整性(即G-ratio)、Western blotting法测定磷酸化哺乳动物雷帕霉素靶蛋白(pmTOR)/哺乳动物雷帕霉素靶蛋白(mTOR)比值.结果 与假手术组相比,模型组大鼠嗅探时间(t=58.000,P=0.000)和穿越次数(t=20.000,P=0.000)减少,胼胝体MBP阳性细胞数目...

Alternative Titles

Full title

褪黑素对慢性脑低灌注大鼠脑白质的保护作用

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Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_wanfang_journals_xdsjjbzz201907006

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_xdsjjbzz201907006

Other Identifiers

ISSN

1672-6731

DOI

10.3969/j.issn.1672-6731.2019.07.005

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