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GINS1通过激活Notch/PI3K/AKT/mTORC1信号通路增强肺腺癌细胞糖酵解、增殖和转移

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GINS1通过激活Notch/PI3K/AKT/mTORC1信号通路增强肺腺癌细胞糖酵解、增殖和转移

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_zgfazz202410002

GINS1通过激活Notch/PI3K/AKT/mTORC1信号通路增强肺腺癌细胞糖酵解、增殖和转移

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Full title

GINS1通过激活Notch/PI3K/AKT/mTORC1信号通路增强肺腺癌细胞糖酵解、增殖和转移

Author / Creator

霍怡杉 , 徐晓慧 , 马秀敏 and 冯阳春

Publisher

830011 乌鲁木齐,新疆医科大学附属肿瘤医院医学检验中心

Journal title

中国肺癌杂志, 2024, Vol.27 (10), p.735-744

Language

Chinese

Formats

Articles

Publication information

Publisher

830011 乌鲁木齐,新疆医科大学附属肿瘤医院医学检验中心

More information

Scope and Contents

Contents

背景与目的 肺癌是所有癌症类型中占比最大的一种,其中肺腺癌(lung adenocarcinoma,LUAD)占肺癌患者的一半以上.目前,转移性LUAD患者5年生存率仍然较低,迫切需要新型生物标志物作为靶向治疗的靶点.Go-Ichi-Ni-San1(GINS1)是G1NS家族的重要成员,与人类恶性肿瘤的发生和发展密切相关.本研究旨在探究GINS1在LUAD细胞糖酵解、增殖和转移过程中的作用及相关分子机制.方法 通过生物信息学分析GINS1在LUAD患者和健康人群中的表达差异.通过免疫组织化学染色和Western blot检测GINS1在LUAD组织和癌旁组织中的表达水平,采用Western blot和实时荧光定量聚合酶链式反应(real-time fluorescence quantitat...

Alternative Titles

Full title

GINS1通过激活Notch/PI3K/AKT/mTORC1信号通路增强肺腺癌细胞糖酵解、增殖和转移

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Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_wanfang_journals_zgfazz202410002

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_zgfazz202410002

Other Identifiers

ISSN

1009-3419

DOI

10.3779/j.issn.1009-3419.2024.101.27

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