针刺后溪和环跳对腰椎间盘突出症模型大鼠NF-κB/iNOS/NO通路的影响
针刺后溪和环跳对腰椎间盘突出症模型大鼠NF-κB/iNOS/NO通路的影响
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Contents
R2-03; 目的:观察针刺后溪和环跳对腰椎间盘突出症(LDH)模型大鼠L5脊神经根核因子κB(NF-κB)炎性信号通路中NF-κB、诱导型一氧化氮合酶(iNOS)及一氧化氮(NO)表达的影响,探讨针刺治疗LDH的作用机制.方法:将40只健康无特定病原体级雄性Sprague-Dawley大鼠按随机数字表法分为假手术组、模型组、针刺1组和针刺2组,每组10只.通过穿刺L4-L5棘突间隙注射自体髓核混悬液制成非压迫髓核突出模型.针刺1组针刺双侧肾俞、大肠俞和委中;针刺2组针刺双侧后溪和环跳.均采用平补平泻手法,每次留针30 min,每隔10 min行针1次,每日1次,共治疗14次.用热刺痛仪进行缩爪痛阈值测定;酶联免疫吸附法测定血清NF-κB、iNOS及NO水平;苏木素-伊红(HE)染色法观察脊...
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Full title
针刺后溪和环跳对腰椎间盘突出症模型大鼠NF-κB/iNOS/NO通路的影响
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TN_cdi_wanfang_journals_zjtnyx_e202304002
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_wanfang_journals_zjtnyx_e202304002
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ISSN
1672-3597
DOI
10.1007/s11726-023-1383-3
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