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Select record 21
ArticlesPeer ReviewedFull Text
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis
Author / Creator:Wang, Zongqiang ; Forelli, Nicholas ; Hernandez, Yozen ; Ternei, Melinda ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.842-842, Article 842
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Multiplexed mobilization and expression of biosynthetic gene clusters
Author / Creator:Libis, Vincent ; MacIntyre, Logan W. ; Mehmood, Rabia ; Guerrero, Liliana ; Ternei, Melinda A. ; Antonovsky, Niv ; Burian, Ján ; Wang, Zongqiang ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5256-5256, Article 5256
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Chemical-biogeographic survey of secondary metabolism in soil
Author / Creator:Charlop-Powers, Zachary ; Owen, Jeremy G ; Reddy, Boojala Vijay B ; Ternei, Melinda A ; Brady, Sean F
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3757-3762
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High-throughput retrieval of target sequences from complex clone libraries using CRISPRi
Author / Creator:Burian, Ján ; Libis, Vincent K. ; Hernandez, Yozen A. ; Guerrero-Porras, Liliana ; Ternei, Melinda A. ; Brady, Sean F.
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2023-05, Vol.41 (5), p.626-630
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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
Author / Creator:Owen, Jeremy G. ; Reddy, Boojala Vijay B. ; Ternei, Melinda A. ; Charlop-Powers, Zachary ; Calle, Paula Y. ; Kim, Jeffrey H. ; Brady, Sean F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.11797-11802
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Unraveling function and diversity of bacterial lectins in the human microbiome
Author / Creator:Cohen, Louis J. ; Han, Sun M. ; Lau, Pearson ; Guisado, Daniela ; Liang, Yupu ; Nakashige, Toshiki G. ; Ali, Thamina ; Chiang, David ; Rahman, Adeeb ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-06, Vol.13 (1), p.3101-3101, Article 3101
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Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
Author / Creator:Owen, Jeremy G. ; Charlop-Powers, Zachary ; Smith, Alexandra G. ; Ternei, Melinda A. ; Calle, Paula Y. ; Reddy, Boojala Vijay B. ; Montiel, Daniel ; Brady, Sean F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (14), p.4221-4226
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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
Author / Creator:Peek, James ; Lilic, Mirjana ; Montiel, Daniel ; Milshteyn, Aleksandr ; Woodworth, Ian ; Biggins, John B. ; Ternei, Melinda A. ; Calle, Paula Y. ; Danziger, Michael ; Warrier, Thulasi ; Saito, Kohta ; Braffman, Nathaniel ; Fay, Allison ; Glickman, Michael S. ; Darst, Seth A. ; Campbell, Elizabeth A. ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4147-15, Article 4147
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Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary
Author / Creator:Banik, Jacob J ; Brady, Sean F
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (45), p.17273-17277
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Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host
Author / Creator:Bitok, J. Kipchirchir ; Lemetre, Christophe ; Ternei, Melinda A. ; Brady, Sean F.
Publisher:England: Oxford University Press
Journal title:FEMS microbiology letters, 2017-09, Vol.364 (16)
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Global biogeographic sampling of bacterial secondary metabolism
Author / Creator:Charlop-Powers, Zachary ; Owen, Jeremy G ; Reddy, Boojala Vijay B ; Ternei, Melinda A ; Guimarães, Denise O ; de Frias, Ulysses A ; Pupo, Monica T ; Seepe, Prudy ; Feng, Zhiyang ; Brady, Sean F
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2015-01, Vol.4, p.e05048-e05048
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ArticlesPeer ReviewedFull Text
Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome
Author / Creator:Dror, Barak ; Wang, Zongqiang ; Brady, Sean F ; Jurkevitch, Edouard ; Cytryn, Eddie
Publisher:United States: American Society for Microbiology
Journal title:mSystems, 2020-12, Vol.5 (6)
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Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals
Author / Creator:Piscotta, Frank J ; Hoffmann, Hans-Heinrich ; Choi, Young Joo ; Small, Gabriel I ; Ashbrook, Alison W ; Koirala, Bimal ; Campbell, Elizabeth A ; Darst, Seth A ; Rice, Charles M ; Brady, Sean F
Publisher:United States: American Society for Microbiology
Journal title:mSphere, 2021-12, Vol.6 (6), p.e0071121-e0071121
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ArticlesPeer ReviewedFull Text
A naturally inspired antibiotic to target multidrug-resistant pathogens
Author / Creator:Wang, Zongqiang ; Koirala, Bimal ; Hernandez, Yozen ; Zimmerman, Matthew ; Park, Steven ; Perlin, David S. ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-01, Vol.601 (7894), p.606-611
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Select record 35
ArticlesPeer ReviewedFull Text
The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes
Author / Creator:Qaisar, Uzma ; Luo, Liming ; Haley, Cecily L ; Brady, Sean F ; Carty, Nancy L ; Colmer-Hamood, Jane A ; Hamood, Abdul N
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-04, Vol.8 (4), p.e62735-e62735
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Select record 36
ArticlesPeer ReviewedFull Text
Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules
Author / Creator:Brady, Sean F
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2007-05, Vol.2 (5), p.1297-1305
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Select record 37
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An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii -Infected Wounds
Author / Creator:Vila-Farres, Xavier ; Chu, John ; Ternei, Melinda A ; Lemetre, Christophe ; Park, Steven ; Perlin, David S ; Brady, Sean F
Publisher:United States: American Society for Microbiology
Journal title:mSphere, 2018-01, Vol.3 (1)
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Select record 38
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Commensal bacteria make GPCR ligands that mimic human signalling molecules
Author / Creator:Cohen, Louis J. ; Esterhazy, Daria ; Kim, Seong-Hwan ; Lemetre, Christophe ; Aguilar, Rhiannon R. ; Gordon, Emma A. ; Pickard, Amanda J. ; Cross, Justin R. ; Emiliano, Ana B. ; Han, Sun M. ; Chu, John ; Vila-Farres, Xavier ; Kaplitt, Jeremy ; Rogoz, Aneta ; Calle, Paula Y. ; Hunter, Craig ; Bitok, J. Kipchirchir ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-09, Vol.549 (7670), p.48-53
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Bacterial cGAS senses a viral RNA to initiate immunity
Author / Creator:Banh, Dalton V. ; Roberts, Cameron G. ; Morales-Amador, Adrian ; Berryhill, Brandon A. ; Chaudhry, Waqas ; Levin, Bruce R. ; Brady, Sean F. ; Marraffini, Luciano A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-11, Vol.623 (7989), p.1001-1008
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Select record 40
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Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens
Author / Creator:Hover, Bradley M. ; Kim, Seong-Hwan ; Katz, Micah ; Charlop-Powers, Zachary ; Owen, Jeremy G. ; Ternei, Melinda A. ; Maniko, Jeffrey ; Estrela, Andreia B. ; Molina, Henrik ; Park, Steven ; Perlin, David S. ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature microbiology, 2018-04, Vol.3 (4), p.415-422
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Showing 21 to 40 of 53 results

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Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

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Multiplexed mobilization and expression of biosynthetic gene clusters

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Chemical-biogeographic survey of secondary metabolism in soil

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High-throughput retrieval of target sequences from complex clone libraries using CRISPRi

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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

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Unraveling function and diversity of bacterial lectins in the human microbiome

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Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

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Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

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Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host

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Global biogeographic sampling of bacterial secondary metabolism

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Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome

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Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

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A naturally inspired antibiotic to target multidrug-resistant pathogens

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The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes

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Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules

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An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii -Infected Wounds

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Commensal bacteria make GPCR ligands that mimic human signalling molecules

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Bacterial cGAS senses a viral RNA to initiate immunity

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Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

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