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ArticlesPeer ReviewedFull Text
Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection
Author / Creator:Wooddell, Christine I ; Rozema, David B ; Hossbach, Markus ; John, Matthias ; Hamilton, Holly L ; Chu, Qili ; Hegge, Julia O ; Klein, Jason J ; Wakefield, Darren H ; Oropeza, Claudia E ; Deckert, Jochen ; Roehl, Ingo ; Jahn-Hofmann, Kerstin ; Hadwiger, Philipp ; Vornlocher, Hans-Peter ; McLachlan, Alan ; Lewis, David L
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2013-05, Vol.21 (5), p.973-985
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A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide
Author / Creator:Gusev, Artem Evgenievich ; Ivanov, Vladimir Nikolaevich ; Dmitriev, Nikolai Andreevich ; Kholstov, Aleksandr Viktorovich ; Vasilichin, Vladislav Aleksandrovich ; Kofiadi, Ilya Andreevich ; Khaitov, Musa Rakhimovich
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-12, Vol.29 (24), p.5959
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Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
Author / Creator:Debets, Marjoke F. ; Tastan, Omur Y. ; Wisnovsky, Simon P. ; Malaker, Stacy A. ; Angelis, Nikolaos ; Moeckl, Leonhard K. R. ; Choi, Junwon ; Flynn, Helen ; Wagner, Lauren J. S. ; Bineva-Todd, Ganka ; Antonopoulos, Aristotelis ; Cioce, Anna ; Browne, William M. ; Li, Zhen ; Briggs, David C. ; Douglas, Holly L. ; Hess, Gaelen T. ; Agbay, Anthony J. ; Roustan, Chloe ; Kjaer, Svend ; Haslam, Stuart M. ; Snijders, Ambrosius P. ; Bassik, Michael C. ; Moerner, W. E. ; Li, Vivian S. W. ; Bertozzi, Carolyn R. ; Schumann, Benjamin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (41), p.25293-25301
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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Author / Creator:Janas, Maja M. ; Schlegel, Mark K. ; Harbison, Carole E. ; Yilmaz, Vedat O. ; Jiang, Yongfeng ; Parmar, Rubina ; Zlatev, Ivan ; Castoreno, Adam ; Xu, Huilei ; Shulga-Morskaya, Svetlana ; Rajeev, Kallanthottathil G. ; Manoharan, Muthiah ; Keirstead, Natalie D. ; Maier, Martin A. ; Jadhav, Vasant
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-02, Vol.9 (1), p.723-10, Article 723
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Oligonucleotide Therapeutics — A New Class of Cholesterol-Lowering Drugs
Author / Creator:Khvorova, Anastasia
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-01, Vol.376 (1), p.4-7
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A single sulfatase is required to access colonic mucin by a gut bacterium
Author / Creator:Luis, Ana S. ; Jin, Chunsheng ; Pereira, Gabriel Vasconcelos ; Glowacki, Robert W. P. ; Gugel, Sadie R. ; Singh, Shaleni ; Byrne, Dominic P. ; Pudlo, Nicholas A. ; London, James A. ; Baslé, Arnaud ; Reihill, Mark ; Oscarson, Stefan ; Eyers, Patrick A. ; Czjzek, Mirjam ; Michel, Gurvan ; Barbeyron, Tristan ; Yates, Edwin A. ; Hansson, Gunnar C. ; Karlsson, Niclas G. ; Cartmell, Alan ; Martens, Eric C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-10, Vol.598 (7880), p.332-337
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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
Author / Creator:Zimmermann, Tracy S. ; Karsten, Verena ; Chan, Amy ; Chiesa, Joseph ; Boyce, Malcolm ; Bettencourt, Brian R. ; Hutabarat, Renta ; Nochur, Saraswathy ; Vaishnaw, Akshay ; Gollob, Jared
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2017-01, Vol.25 (1), p.71-78
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In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
Author / Creator:Laughlin, Scott T ; Baskin, Jeremy M ; Amacher, Sharon L ; Bertozzi, Carolyn R
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2008-05, Vol.320 (5876), p.664-667
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Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)
Author / Creator:Sten, Sebastian ; Cardilin, Tim ; Antonsson, Madeleine ; Gennemark, Peter
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2023-12, Vol.62 (12), p.1661-1672
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Genetic and functional diversity of β-N-acetylgalactosamine-targeting glycosidases expanded by deep-sea metagenome analysis
Author / Creator:Sumida, Tomomi ; Hiraoka, Satoshi ; Usui, Keiko ; Ishiwata, Akihiro ; Sengoku, Toru ; Stubbs, Keith A. ; Tanaka, Katsunori ; Deguchi, Shigeru ; Fushinobu, Shinya ; Nunoura, Takuro
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.3543-3543, Article 3543
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Galactosaminoglycans: Medical Applications and Drawbacks
Author / Creator:Pomin, Vitor H. ; Vignovich, William P. ; Gonzales, Alysia V. ; Vasconcelos, Ariana A. ; Mulloy, Barbara
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-08, Vol.24 (15), p.2803
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Characterisation of the main PSA glycoforms in aggressive prostate cancer
Author / Creator:Gratacós-Mulleras, Anna ; Duran, Adrià ; Asadi Shehni, Akram ; Ferrer-Batallé, Montserrat ; Ramírez, Manel ; Comet, Josep ; de Llorens, Rafael ; Saldova, Radka ; Llop, Esther ; Peracaula, Rosa
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-11, Vol.10 (1), p.18974-18974, Article 18974
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Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels
Author / Creator:Moldoveanu, Z. ; Wyatt, R.J. ; Lee, J.Y. ; Tomana, M. ; Julian, B.A. ; Mestecky, J. ; Huang, W.-Q. ; Anreddy, S.R. ; Hall, S. ; Hastings, M.C. ; Lau, K.K. ; Cook, W.J. ; Novak, J.
Publisher:United States: Elsevier Inc
Journal title:Kidney international, 2007-06, Vol.71 (11), p.1148-1154
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Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
Author / Creator:Clua, Anna ; Grijalvo, Santiago ; Erande, Namrata ; Gupta, Swati ; Yucius, Kristina ; Gargallo, Raimundo ; Mazzini, Stefania ; Manoharan, Muthiah ; Eritja, Ramon
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-06, Vol.27 (12), p.3944
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Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells
Author / Creator:Schjoldager, Katrine T.-B. G ; Vakhrushev, Sergey Y ; Kong, Yun ; Steentoft, Catharina ; Nudelman, Aaron S ; Pedersen, Nis B ; Wandall, Hans H ; Mandel, Ulla ; Bennett, Eric P ; Levery, Steven B ; Clausen, Henrik
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (25), p.9893-9898
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Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain
Author / Creator:Hirata, Tetsuya ; Mishra, Sushil K. ; Nakamura, Shota ; Saito, Kazunobu ; Motooka, Daisuke ; Takada, Yoko ; Kanzawa, Noriyuki ; Murakami, Yoshiko ; Maeda, Yusuke ; Fujita, Morihisa ; Yamaguchi, Yoshiki ; Kinoshita, Taroh
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-01, Vol.9 (1), p.405-16, Article 405
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Chemoenzymatic synthesis of the bacterial polysaccharide repeating unit undecaprenyl pyrophosphate and its analogs
Author / Creator:Li, Lei ; Woodward, Robert L ; Han, Weiqing ; Qu, Jingyao ; Song, Jing ; Ma, Cheng ; Wang, Peng G
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2016-07, Vol.11 (7), p.1280-1298
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Chemical Synthesis of Fucosylated Chondroitin Sulfate Tetrasaccharide with Fucosyl Branch at the 6-OH of GalNAc Residue
Author / Creator:Lv, Changlun ; Li, Xiaona ; Yang, Guoqing ; Chen, Haijiao ; Li, Chunxia
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2024-04, Vol.22 (4), p.184
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Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
Author / Creator:Cedillo, Isaiah ; Chreng, Dana ; Engle, Elyse ; Chen, Lijian ; McPherson, Andrew ; Rodriguez, Andrew
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-08, Vol.22 (8), p.1356
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Identification of N-glycans with GalNAc-containing antennae from recombinant HIV trimers by ion mobility and negative ion fragmentation
Author / Creator:Harvey, David J. ; Behrens, Anna-Janina ; Crispin, Max ; Struwe, Weston B.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2021-12, Vol.413 (29), p.7229-7240
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Showing 1 to 20 of 54 results

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Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

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A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

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Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

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Oligonucleotide Therapeutics — A New Class of Cholesterol-Lowering Drugs

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A single sulfatase is required to access colonic mucin by a gut bacterium

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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

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In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

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Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)

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Genetic and functional diversity of β-N-acetylgalactosamine-targeting glycosidases expanded by deep-sea metagenome analysis

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Galactosaminoglycans: Medical Applications and Drawbacks

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Characterisation of the main PSA glycoforms in aggressive prostate cancer

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Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels

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Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes

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Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells

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Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain

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Chemoenzymatic synthesis of the bacterial polysaccharide repeating unit undecaprenyl pyrophosphate and its analogs

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Chemical Synthesis of Fucosylated Chondroitin Sulfate Tetrasaccharide with Fucosyl Branch at the 6-OH of GalNAc Residue

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Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

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Identification of N-glycans with GalNAc-containing antennae from recombinant HIV trimers by ion mobility and negative ion fragmentation

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