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Engineered therapeutic antibodies with improved effector functions
Author / Creator:Kubota, Tsuguo ; Niwa, Rinpei ; Satoh, Mitsuo ; Akinaga, Shiro ; Shitara, Kenya ; Hanai, Nobuo
Publisher:Melbourne, Australia: Blackwell Publishing Asia
Journal title:Cancer science, 2009-09, Vol.100 (9), p.1566-1572
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Stevens–Johnson Syndrome associated with mogamulizumab treatment of adult T‐cell leukemia / lymphoma
Author / Creator:Ishida, Takashi ; Ito, Asahi ; Sato, Fumihiko ; Kusumoto, Shigeru ; Iida, Shinsuke ; Inagaki, Hiroshi ; Morita, Akimichi ; Akinaga, Shiro ; Ueda, Ryuzo
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2013-05, Vol.104 (5), p.647-650
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Genetically engineered humanized anti‐ganglioside GM2 antibody against multiple organ metastasis produced by GM2‐expressing small‐cell lung cancer cells
Author / Creator:Yamada, Tadaaki ; Bando, Hideaki ; Takeuchi, Shinji ; Kita, Kenji ; Li, Qi ; Wang, Wei ; Akinaga, Shiro ; Nishioka, Yasuhiko ; Sone, Saburo ; Yano, Seiji
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Cancer science, 2011-12, Vol.102 (12), p.2157-2163
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Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole
Author / Creator:Umehara, Hiroshi ; Maekawa, Yoshimi ; Koizumi, Fumito ; Shimizu, Makiko ; Ota, Toshio ; Fouad, Tamer M. ; Willey, Jie ; Kaito, Hidekuni ; Shiraishi, Norihiko ; Nakashima, Daisuke ; Akinaga, Shiro ; Ueno, Naoto T.
Publisher:London, England: SAGE Publications
Journal title:Therapeutic advances in medical oncology, 2018-01, Vol.10, p.1758835918786858
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Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in Japanese patients with solid tumors
Author / Creator:Niwakawa, Masashi ; Yamaguchi, Raizo ; Onozawa, Yusuke ; Yasui, Hirofumi ; Taku, Keisei ; Naito, Tateaki ; Akinaga, Shiro ; Boku, Narikazu ; Yamamoto, Nobuyuki
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2013-08, Vol.104 (8), p.1039-1044
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A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models
Author / Creator:Ishida, Hiroyuki ; Nakata, Taisuke ; Suzuki, Masayo ; Shiotsu, Yukimasa ; Tanaka, Hideyuki ; Sato, Natsuko ; Terasaki, Yoko ; Takebayashi, Miho ; Anazawa, Hideharu ; Murakata, Chikara ; Li, Pui-Kai ; Kuwabara, Takashi ; Akinaga, Shiro
Publisher:Dordrecht: Springer
Journal title:Breast cancer research and treatment, 2007-12, Vol.106 (2), p.215-227
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Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo
Author / Creator:Ishida, Hiroyuki ; Nakata, Taisuke ; Sato, Natsuko ; Li, Pui-Kai ; Kuwabara, Takashi ; Akinaga, Shiro
Publisher:Dordrecht: Springer
Journal title:Breast cancer research and treatment, 2007-08, Vol.104 (2), p.211-219
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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts
Author / Creator:Kurebayashi, Junichi ; Otsuki, Takemi ; Kurosumi, Masafumi ; Soga, Shiro ; Akinaga, Shiro ; Sonoo, Hiroshi
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Cancer science, 2001-12, Vol.92 (12), p.1342-1351
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Stereospecific antitumor activity of radicicol oxime derivatives
Author / Creator:Soga, Shiro ; Sharma, Sreenath ; Shiotsu, Yukimasa ; Shimizu, Makiko ; Tahara, Harunobu ; Yamaguchi, Kazuo ; Ikuina, Yoji ; Murakata, Chikara ; Tamaoki, Tatsuya ; Kurebayashi, Junichi ; Schulte, Theodor ; Neckers, Leonard ; Akinaga, Shiro
Publisher:Berlin: Springer
Journal title:Cancer chemotherapy and pharmacology, 2001-12, Vol.48 (6), p.435-445
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UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery
Author / Creator:Abe, Sadanori ; Kubota, Tetsuro ; Otani, Yoshihide ; Furukawa, Toshiharu ; Watanabe, Masahiko ; Kumai, Koichiro ; Akiyama, Tadakazu ; Akinaga, Shiro ; Kitajima, Masaki
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Cancer science, 2001-05, Vol.92 (5), p.537-545
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A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer
Author / Creator:Kang, Yoon-Koo ; Muro, Kei ; Ryu, Min-Hee ; Yasui, Hirofumi ; Nishina, Tomohiro ; Ryoo, Baek-Yeol ; Kamiya, Yukimasa ; Akinaga, Shiro ; Boku, Narikazu
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2014-04, Vol.32 (2), p.355-361
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Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration
Author / Creator:Takahashi, Takeshi ; Kanazawa, Junji ; Akinaga, Shiro ; Tamaoki, Tatsuya ; Okabe, Masami
Publisher:Berlin: Springer
Journal title:Cancer chemotherapy and pharmacology, 1999-03, Vol.43 (3), p.233-240
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Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01
Author / Creator:Kurata, Noriaki ; Kuwabara, Takashi ; Tanii, Hiromi ; Fuse, Eiichi ; Akiyama, Tadakazu ; Akinaga, Shiro ; Kobayashi, Hiroyuki ; Yamaguchi, Ken ; Kobayashi, Satoshi
Publisher:Berlin: Springer
Journal title:Cancer chemotherapy and pharmacology, 1999, Vol.44 (1), p.12-18
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A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors
Author / Creator:Wakui, Hiroshi ; Yamamoto, Noboru ; Kitazono, Satoru ; Mizugaki, Hidenori ; Nakamichi, Shinji ; Fujiwara, Yutaka ; Nokihara, Hiroshi ; Yamada, Yasuhide ; Suzuki, Kohei ; Kanda, Hironori ; Akinaga, Shiro ; Tamura, Tomohide
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2014-07, Vol.74 (1), p.15-23
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Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity
Author / Creator:Schwartz, Gary K. ; Dickson, Mark A. ; LoRusso, Patricia M. ; Sausville, Edward A. ; Maekawa, Yoshimi ; Watanabe, Yasuo ; Kashima, Naomi ; Nakashima, Daisuke ; Akinaga, Shiro
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2016-04, Vol.107 (4), p.499-506
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ArticlesPeer ReviewedFull Text
Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in J apanese patients with solid tumors
Author / Creator:Niwakawa, Masashi ; Yamaguchi, Raizo ; Onozawa, Yusuke ; Yasui, Hirofumi ; Taku, Keisei ; Naito, Tateaki ; Akinaga, Shiro ; Boku, Narikazu ; Yamamoto, Nobuyuki
Journal title:Cancer science, 2013-08, Vol.104 (8), p.1039-1044
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Stevens–Johnson S yndrome associated with mogamulizumab treatment of adult T ‐cell leukemia / lymphoma
Author / Creator:Ishida, Takashi ; Ito, Asahi ; Sato, Fumihiko ; Kusumoto, Shigeru ; Iida, Shinsuke ; Inagaki, Hiroshi ; Morita, Akimichi ; Akinaga, Shiro ; Ueda, Ryuzo
Journal title:Cancer science, 2013-05, Vol.104 (5), p.647-650
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Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin
Author / Creator:Schulte, Theodor W. ; Akinaga, Shiro ; Soga, Shiro ; Sullivan, William ; Stensgard, Bridget ; Toft, David ; Neckers, Leonard M.
Publisher:Netherlands: Churchill Livingstone
Journal title:Cell stress & chaperones, 1998-06, Vol.3 (2), p.100-108
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Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM
Author / Creator:Takahashi, Takeshi ; Shimizu, Makiko ; Akinaga, Shiro
Publisher:Germany: Springer Nature B.V
Journal title:Cancer chemotherapy and pharmacology, 2002-09, Vol.50 (3), p.193-201
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Identification of Ras Farnesyltransferase Inhibitors by Microbial Screening
Author / Creator:Hara, Mitsunobu ; Akasaka, Kazuhito ; Akinaga, Shiro ; Okabe, Masami ; Nakano, Hirofumi ; Gomez, Ruben ; Wood, Douglas ; Uh, Misook ; Tamanoi, Fuyuhiko
Publisher:Washington, DC: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (6), p.2281-2285
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Showing 1 to 20 of 25 results

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Engineered therapeutic antibodies with improved effector functions

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Stevens–Johnson Syndrome associated with mogamulizumab treatment of adult T‐cell leukemia / lymphoma

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Genetically engineered humanized anti‐ganglioside GM2 antibody against multiple organ metastasis produced by GM2‐expressing small‐cell lung cancer cells

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Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole

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Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in Japanese patients with solid tumors

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A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models

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Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo

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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

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Stereospecific antitumor activity of radicicol oxime derivatives

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UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery

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A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer

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Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration

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Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

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A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors

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Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

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Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in J apanese patients with solid tumors

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Stevens–Johnson S yndrome associated with mogamulizumab treatment of adult T ‐cell leukemia / lymphoma

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Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin

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Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM

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Identification of Ras Farnesyltransferase Inhibitors by Microbial Screening

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