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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Author / Creator:Hur, Ji-Yeun ; Frost, Georgia R. ; Wu, Xianzhong ; Crump, Christina ; Pan, Si Jia ; Wong, Eitan ; Barros, Marilia ; Li, Thomas ; Nie, Pengju ; Zhai, Yujia ; Wang, Jen Chyong ; TCW, Julia ; Guo, Lei ; McKenzie, Andrew ; Ming, Chen ; Zhou, Xianxiao ; Wang, Minghui ; Sagi, Yotam ; Renton, Alan E. ; Esposito, Bianca T. ; Kim, Yong ; Sadleir, Katherine R. ; Trinh, Ivy ; Rissman, Robert A. ; Vassar, Robert ; Zhang, Bin ; Johnson, Douglas S. ; Masliah, Eliezer ; Greengard, Paul ; Goate, Alison ; Li, Yue-Ming
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-10, Vol.586 (7831), p.735-740
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Author / Creator:Jonsson, Thorlakur ; Atwal, Jasvinder K. ; Steinberg, Stacy ; Snaedal, Jon ; Jonsson, Palmi V. ; Bjornsson, Sigurbjorn ; Stefansson, Hreinn ; Sulem, Patrick ; Gudbjartsson, Daniel ; Maloney, Janice ; Hoyte, Kwame ; Gustafson, Amy ; Liu, Yichin ; Lu, Yanmei ; Bhangale, Tushar ; Graham, Robert R. ; Huttenlocher, Johanna ; Bjornsdottir, Gyda ; Andreassen, Ole A. ; Jönsson, Erik G. ; Palotie, Aarno ; Behrens, Timothy W. ; Magnusson, Olafur T. ; Kong, Augustine ; Thorsteinsdottir, Unnur ; Watts, Ryan J. ; Stefansson, Kari
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-08, Vol.488 (7409), p.96-99
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γ-Secretase in Alzheimer’s disease
Author / Creator:Hur, Ji-Yeun
Publisher:London: Nature Publishing Group UK
Journal title:Experimental and Molecular Medicine, 2022, 54(0), , pp.1-14
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
Author / Creator:Miranda, André Miguel Lopes ; Lasiecka, Zofia M. ; Xu, Yimeng ; Neufeld, Jessi ; Shahriar, Sanjid ; Simoes, Sabrina ; Chan, Robin B. ; Oliveira, Tiago Gil ; Small, Scott A. ; Di Paolo, Gilbert
Publisher:London: Nature Research
Journal title:Nature communications, 2018-01, Vol.9 (1), p.291-16, Article 291
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Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons
Author / Creator:Laulagnier, Karine ; Javalet, Charlotte ; Hemming, Fiona J. ; Chivet, Mathilde ; Lachenal, Gaëlle ; Blot, Béatrice ; Chatellard, Christine ; Sadoul, Rémy
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2018-02, Vol.75 (4), p.757-773
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Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations
Author / Creator:Zorkina, Yana ; Abramova, Olga ; Ushakova, Valeriya ; Morozova, Anna ; Zubkov, Eugene ; Valikhov, Marat ; Melnikov, Pavel ; Majouga, Alexander ; Chekhonin, Vladimir
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2020-11, Vol.25 (22), p.5294
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η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Author / Creator:Willem, Michael ; Tahirovic, Sabina ; Busche, Marc Aurel ; Ovsepian, Saak V. ; Chafai, Magda ; Kootar, Scherazad ; Hornburg, Daniel ; Evans, Lewis D. B. ; Moore, Steven ; Daria, Anna ; Hampel, Heike ; Müller, Veronika ; Giudici, Camilla ; Nuscher, Brigitte ; Wenninger-Weinzierl, Andrea ; Kremmer, Elisabeth ; Heneka, Michael T. ; Thal, Dietmar R. ; Giedraitis, Vilmantas ; Lannfelt, Lars ; Müller, Ulrike ; Livesey, Frederick J. ; Meissner, Felix ; Herms, Jochen ; Konnerth, Arthur ; Marie, Hélène ; Haass, Christian
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-10, Vol.526 (7573), p.443-447
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The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
Author / Creator:Barrett, Paul J. ; Song, Yuanli ; Van Horn, Wade D. ; Hustedt, Eric J. ; Schafer, Johanna M. ; Hadziselimovic, Arina ; Beel, Andrew J. ; Sanders, Charles R.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-06, Vol.336 (6085), p.1168-1171
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ArticlesPeer ReviewedFull Text
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Author / Creator:NIKOLAEV, Anatoly ; MCLAUGHLIN, Todd ; O'LEARY, Dennis D. M ; TESSIER-LAVIGNE, Marc
Publisher:London: Nature Publishing Group
Journal title:Nature, 2009-02, Vol.457 (7232), p.981-989
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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
Author / Creator:Morel, Etienne ; Chamoun, Zeina ; Lasiecka, Zofia M. ; Chan, Robin B. ; Williamson, Rebecca L. ; Vetanovetz, Christopher ; Dall’Armi, Claudia ; Simoes, Sabrina ; Point Du Jour, Kimberly S. ; McCabe, Brian D. ; Small, Scott A. ; Di Paolo, Gilbert
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2013-08, Vol.4 (1), p.2250, Article 2250
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Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease
Author / Creator:He, Gen ; Luo, Wenjie ; Li, Peng ; Remmers, Christine ; Netzer, William J. ; Hendrick, Joseph ; Bettayeb, Karima ; Flajolet, Marc ; Gorelick, Fred ; Wennogle, Lawrence P. ; Greengard, Paul
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-09, Vol.467 (7311), p.95-98
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Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
Author / Creator:Krohn, Markus ; Lange, Cathleen ; Hofrichter, Jacqueline ; Scheffler, Katja ; Stenzel, Jan ; Steffen, Johannes ; Schumacher, Toni ; Brüning, Thomas ; Plath, Anne-Sophie ; Alfen, Franziska ; Schmidt, Anke ; Winter, Felix ; Rateitschak, Katja ; Wree, Andreas ; Gsponer, Jörg ; Walker, Lary C ; Pahnke, Jens
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-10, Vol.121 (10), p.3924-3931
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Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environm...
Author / Creator:Volynsky, Pavel E ; Urban, Anatoly S ; Pavlov, Konstantin V ; Bershatsky, Yaroslav V ; Bocharova, Olga V ; Kryuchkova, Anastasia K ; Zlobina, Veronika V ; Gavrilenkova, Alina A ; Dolotova, Sofya M ; Kamynina, Anna V ; Zangieva, Olga T ; Taldaev, Amir ; Batishchev, Oleg V ; Okhrimenko, Ivan S ; Rakitina, Tatiana V ; Efremov, Roman G ; Bocharov, Eduard V
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-01, Vol.26 (2), p.553
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APP, PSEN1 , and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease
Author / Creator:Giau, Vo Van ; Bagyinszky, Eva ; Youn, Young Chul ; An, Seong Soo A ; Kim, SangYun
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-09, Vol.20 (19), p.4757
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Oxidation destabilizes toxic amyloid beta peptide aggregation
Author / Creator:Razzokov, J. ; Yusupov, M. ; Bogaerts, A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-04, Vol.9 (1), p.5476, Article 5476
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Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site
Author / Creator:Chen, Wen ; Gamache, Eric ; Rosenman, David J. ; Xie, Jian ; Lopez, Maria M. ; Li, Yue-Ming ; Wang, Chunyu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-01, Vol.5 (1), p.3037-3037, Article 3037
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Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
Author / Creator:Obregon, Demian ; Hou, Huayan ; Deng, Juan ; Giunta, Brian ; Tian, Jun ; Darlington, Donna ; Shahaduzzaman, Md ; Zhu, Yuyuan ; Mori, Takashi ; Mattson, Mark P. ; Tan, Jun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2012-04, Vol.3 (1), p.777-777, Article 777
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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain
Author / Creator:Ghosal, Kaushik ; Vogt, Daniel L ; Liang, Man ; Shen, Yong ; Lamb, Bruce T ; Pimplikar, Sanjay W
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (43), p.18367-18372
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Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform
Author / Creator:Odorčić, Ivica ; Hamed, Mohamed Belal ; Lismont, Sam ; Chávez-Gutiérrez, Lucía ; Efremov, Rouslan G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.4479-4479, Article 4479
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The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease
Author / Creator:Xia, Qing ; Yang, XinYu ; Shi, JiaBin ; Liu, ZiJie ; Peng, YaHui ; Wang, WenJing ; Li, BoWen ; Zhao, Yu ; Xiao, JiaYing ; Huang, Lei ; Wang, DaYong ; Gao, Xu
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2021-08, Vol.58 (8), p.4038-4050
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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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γ-Secretase in Alzheimer’s disease

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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

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Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons

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Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations

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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

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The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

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Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

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Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

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Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environm...

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APP, PSEN1 , and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease

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Oxidation destabilizes toxic amyloid beta peptide aggregation

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Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

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Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

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Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform

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The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease

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