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ArticlesPeer ReviewedFull Text
Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism
Author / Creator:Rodman, Samuel N. ; Spence, Jacquelyn M. ; Ronnfeldt, Tyler J. ; Zhu, Yueming ; Solst, Shane R. ; O'Neill, Rebecca A. ; Allen, Bryan G. ; Guan, Xiangming ; Spitz, Douglas R. ; Fath, Melissa A.
Publisher:United States: The Radiation Research Society
Journal title:Radiation research, 2016-10, Vol.186 (4), p.385-395
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Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin
Author / Creator:Karsa, Mawar ; Kosciolek, Angelika ; Bongers, Angelika ; Mariana, Anna ; Failes, Tim ; Gifford, Andrew J. ; Kees, Ursula R. ; Cheung, Laurence C. ; Kotecha, Rishi S. ; Arndt, Greg M. ; Haber, Michelle ; Norris, Murray D. ; Sutton, Rosemary ; Lock, Richard B. ; Henderson, Michelle J. ; Somers, Klaartje
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2021-07, Vol.125 (1), p.55-64
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The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity
Author / Creator:Prasad, Chandra Bhushan ; Oo, Adrian ; Liu, Yujie ; Qiu, Zhaojun ; Zhong, Yaogang ; Li, Na ; Singh, Deepika ; Xin, Xiwen ; Cho, Young-Jae ; Li, Zaibo ; Zhang, Xiaoli ; Yan, Chunhong ; Zheng, Qingfei ; Wang, Qi-En ; Guo, Deliang ; Kim, Baek ; Zhang, Junran
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.4667-23, Article 4667
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Auranofin: Repurposing an Old Drug for a Golden New Age
Author / Creator:Roder, Christine ; Thomson, Melanie J.
Publisher:Cham: Springer International Publishing
Journal title:Drugs in R&D, 2015-03, Vol.15 (1), p.13-20
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Investigation of auranofin and gold-containing analogues antibacterial activity against multidrug-resistant Neisseria gonorrhoeae
Author / Creator:Elkashif, Ahmed ; Seleem, Mohamed N.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-03, Vol.10 (1), p.5602-5602, Article 5602
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Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens
Author / Creator:Thangamani, Shankar ; Mohammad, Haroon ; Abushahba, Mostafa F. N. ; Sobreira, Tiago J. P. ; Hedrick, Victoria E. ; Paul, Lake N. ; Seleem, Mohamed N.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-03, Vol.6 (1), p.22571-22571, Article 22571
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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
Author / Creator:Debnath, Anjan ; Parsonage, Derek ; Andrade, Rosa M ; He, Chen ; Cobo, Eduardo R ; Hirata, Ken ; Chen, Steven ; García-Rivera, Guillermina ; Orozco, Esther ; Martínez, Máximo B ; Gunatilleke, Shamila S ; Barrios, Amy M ; Arkin, Michelle R ; Poole, Leslie B ; McKerrow, James H ; Reed, Sharon L
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-06, Vol.18 (6), p.956-960
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Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization
Author / Creator:Abo Elmaaty, Ayman ; Hamed, Mohammed I A ; Ismail, Muhammad I ; B Elkaeed, Eslam ; S Abulkhair, Hamada ; Khattab, Muhammad ; Al-Karmalawy, Ahmed A
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-06, Vol.26 (12), p.3772
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Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes
Author / Creator:Yan, Wenjing ; Zhong, Yongwang ; Hu, Xin ; Xu, Tuan ; Zhang, Yinghua ; Kales, Stephen ; Qu, Yanyan ; Talley, Daniel C. ; Baljinnyam, Bolormaa ; LeClair, Christopher A. ; Simeonov, Anton ; Polster, Brian M. ; Huang, Ruili ; Ye, Yihong ; Rai, Ganesha ; Henderson, Mark J. ; Tao, Dingyin ; Fang, Shengyun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-08, Vol.14 (1), p.4798-4798, Article 4798
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ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
Author / Creator:Wen, Chuangyu ; Wang, Huihui ; Wu, Xiaobin ; He, Lu ; Zhou, Qian ; Wang, Fang ; Chen, Siyu ; Huang, Lanlan ; Chen, Junxiong ; Wang, Huashe ; Ye, Weibiao ; Li, Wende ; Yang, Xiangling ; Liu, Huanliang ; Peng, Junsheng
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2019-10, Vol.10 (11), p.809-16, Article 809
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ArticlesPeer ReviewedFull Text
Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins
Author / Creator:Benhar, Moran ; Forrester, Michael T ; Hess, Douglas T ; Stamler, Jonathan S
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2008-05, Vol.320 (5879), p.1050-1054
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ArticlesPeer ReviewedFull Text
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Author / Creator:Adhireksan, Zenita ; Palermo, Giulia ; Riedel, Tina ; Ma, Zhujun ; Muhammad, Reyhan ; Rothlisberger, Ursula ; Dyson, Paul J. ; Davey, Curt A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-03, Vol.8 (1), p.14860-14860, Article 14860
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Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection
Author / Creator:Abutaleb, Nader S. ; Seleem, Mohamed N.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-05, Vol.10 (1), p.7701-7701, Article 7701
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ArticlesPeer ReviewedFull Text
Protein Metalation by Medicinal Gold Compounds: Identification of the Main Features of the Metalation Process through ESI MS Experiments
Author / Creator:Geri, Andrea ; Massai, Lara ; Messori, Luigi
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-07, Vol.28 (13), p.5196
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Chemical Modification of Auranofin Yields a New Family of Anticancer Drug Candidates: The Gold(I) Phosphite Analogues
Author / Creator:Cirri, Damiano ; Geri, Andrea ; Massai, Lara ; Mannelli, Michele ; Gamberi, Tania ; Magherini, Francesca ; Becatti, Matteo ; Gabbiani, Chiara ; Pratesi, Alessandro ; Messori, Luigi
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1050
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ArticlesPeer ReviewedFull Text
Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci
Author / Creator:AbdelKhalek, Ahmed ; Abutaleb, Nader S. ; Elmagarmid, Khalifa A. ; Seleem, Mohamed N.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-05, Vol.8 (1), p.8353-9, Article 8353
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Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs
Author / Creator:Rodríguez-Enríquez, Sara ; Robledo-Cadena, Diana Xochiquetzal ; Pacheco-Velázquez, Silvia Cecilia ; Vargas-Navarro, Jorge Luis ; Padilla-Flores, Joaquín Alberto ; Kaambre, Tuuli ; Moreno-Sánchez, Rafael
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-09, Vol.19 (9), p.e0309331
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A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis
Author / Creator:Coelho, Rowena Alves ; Joffe, Luna Sobrino ; Alves, Gabriela Machado ; Figueiredo-Carvalho, Maria Helena Galdino ; Brito-Santos, Fábio ; Amaral, Ana Claudia Fernandes ; Rodrigues, Marcio L ; Almeida-Paes, Rodrigo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-05, Vol.15 (5), p.e0229630
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Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
Author / Creator:Seo, Min Ji ; Kim, In Young ; Lee, Dong Min ; Park, Yeon Jung ; Cho, Mi-Young ; Jin, Hyo Joon ; Choi, Kyeong Sook
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2023-01, Vol.14 (1), p.42-42, Article 42
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A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhi...
Author / Creator:Ilari, Andrea ; Baiocco, Paola ; Messori, Luigi ; Fiorillo, Annarita ; Boffi, Alberto ; Gramiccia, Marina ; Di Muccio, Trentina ; Colotti, Gianni
Publisher:Vienna: Springer Vienna
Journal title:Amino acids, 2012-02, Vol.42 (2-3), p.803-811
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Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

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Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin

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The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity

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Auranofin: Repurposing an Old Drug for a Golden New Age

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Investigation of auranofin and gold-containing analogues antibacterial activity against multidrug-resistant Neisseria gonorrhoeae

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Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

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Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

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ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin

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Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

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Allosteric cross-talk in chromatin can mediate drug-drug synergy

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Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection

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Protein Metalation by Medicinal Gold Compounds: Identification of the Main Features of the Metalation Process through ESI MS Experiments

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Chemical Modification of Auranofin Yields a New Family of Anticancer Drug Candidates: The Gold(I) Phosphite Analogues

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Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci

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Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs

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A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis

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Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells

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A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhi...

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