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ObjectiveThis study aimed to review literature if therapeutic strategies in adenocarcinoma in situ of the cervix could lead to a more conservative approach.MethodsA review of the literature was conducted using a Medline search for articles published between 1966 and 2013.ResultsThirty-five studies showed that after a radical cone, 16.5% residual disease in the re-cone or uterus was found. After cone with positive margins, residual abnormalities were found in 49.3%. Thirty-seven studies showed 5% recurrence rate after conservative therapy (large loop excision transformation zone–cold knife conization. After conization with negative margins, the risk of recurrence was 3%.ConclusionsAdenocarcinoma in situ is a relatively rare premalignant but increasingly frequent lesion of the cervix. Although there is a risk of relapse (3%) with a chance of malignancy (<1%), this risk is so small that conservative treatment with negative margins by large loop excision transformation zone or cold knife conization is justified and justifiable not only for women to have children.

International journal of gynecological cancer, 2014-11, Vol.24 (9), p.1543-1548

Adenocarcinoma in Situ of the Uterine Cervix—A Systematic Review

Introduction/BackgroundResearch suggests that most early-stage endometrial cancer patients do not need intensive follow-up. The aim of the ENSURE (Endometrial cancer SURvivors’ follow-up care) trial was to compare satisfaction with care between women who received a reduced follow-up (FU) schedule (4 visits) and women who received the usual FU schedule according to the Dutch guideline (8–11 visits) for three years after treatment.MethodologyIn this multicentre non-inferiority trial, 316 women from 42 hospitals with FIGO stage IA/B endometrial cancer were randomly allocated to reduced FU (n=160) or usual FU care (n=156). The women completed questionnaires at baseline (after surgery), and after 6, 12 and 36 months. The primary outcome was satisfaction with care (PSQ-III) with a predefined noninferiority margin of 6 points (range 0–100). Mixed linear regressions were used.Results299 (95%) women completed the questionnaire at baseline; 291 (92%) at 6-months; 272 (86%) at 12 months and 222 (70%) at 36 months. During three years after treatment, women in the reduced FU group had a median of 3.5 [IQR 3.0–5.0] visits with their specialist/nurse compared to 7.0 [IQR 6.0–9.0] visits for women in the usual FU group. Overall satisfaction with care was similar in the reduced FU (M=82;SD=15) and usual FU (M=82;SD=13) group. At 6, 12 and 36 months, more patients (93/94/90%) in the reduced FU arm were satisfied with their FU schedule than patients in usual FU arm (79/78/82%). Nine women in the reduced FU group and five in the usual FU group developed a recurrence (n.s.).ConclusionWomen receiving reduced follow-up care were just as satisfied with their care as those receiving follow-up care according to Dutch guidelines. Compared to usual care, women in the reduced care group had fewer medical visits and, at the same time, more often reported being satisfied with this reduced frequency.

International journal of gynecological cancer, 2022-10, Vol.32 (Suppl 2), p.A455-A455

2022-RA-683-ESGO The ENSURE trial for women with early-stage endometrial cancer: A randomized controlled trial comparing the effect of a reduced versus usual follow-up schedule on patient satisfaction, health care use, and disease perceptions

ObjectiveThis study aimed to evaluate the treatment and follow-up in a large series of women with early cervical adenocarcinoma (AC), stages IA1 and IA2, and to perform an extensive review of the literature in an effort to ascertain whether conservative therapy is justified.MethodsRecords of 59 cases of microinvasive AC diagnosed between 1987 and 2006 in the Rotterdam district, the Netherlands, were retrieved. Clinical and pathological data were reviewed and analyzed. A mesh review of all relevant literature concerning stage IA1 and IA2 was performed.ResultsOf all patients, 33 had stage IA1 and 26 stage IA2 cervical AC. Also, 42 patients were treated conservatively (ie, conization or simple hysterectomy) and 17 patients were treated radically (ie, radical hysterectomy/trachelectomy with lymph node dissection). Recurrence occurred in 1 patient (1.7%) with stage IA1 disease (grade 1 adenocarcinoma, depth 1.4 mm, and width 3.8 mm, with lymph vascular space involvement [LVSI]) treated by vaginal hysterectomy. The mean follow-up was 79.9 months. From the literature, pooling all data from patients with stage IA1 and IA2 AC, the risk of recurrent disease was 1.5% after conservative therapy and 2.0% after radical therapy.ConclusionsExtensive treatment such as radical hysterectomy with pelvic lymph node dissection or trachelectomy does not prevent recurrent disease. Patients with microinvasive AC should be treated identically to patients with SCC. In stage IA1 and IA2 AC, we recommend conservative therapy (by conization). In cases with LVSI, an additional lymphadenectomy is advised. For patients with stage IA2 AC with LVSI, a trachelectomy/radical hysterectomy with lymph node dissection should be considered.

International journal of gynecological cancer, 2011-12, Vol.21 (9), p.1640-1645

Conservative Therapy in Microinvasive Adenocarcinoma of the Uterine Cervix is Justified: An Analysis of 59 Cases and a Review of the Literature

The Editor would like to publicly acknowledge the people listed below who served as reviewers on the journal during 2017.Without their efforts the quality of the journal could not be sustained.Aacharya Ramesh Aadland Eivind Aakre Ca Aapro M Aaro Leif Aarsland Dag Aasbjerg K Aasdahl Lene Aasekjer Katrine Abas Melanie Abbas Ahmed Abbey Hilary Abbott Jason Abbott Tom Abbruzzese Giovanni Abdel-Aleem Hany Abdel-Karim Abdul-Rahman Abdelazim Ibrahim Abdool Karim Salim Abdool Karim Salim S Abdul Aziz Zariah Abdullah Fizan Abdullah Abu Abdullah Adina Abdullah Asnawi Abdullah Hairil Abe Takayuki Abel Gary Åberg N David Abernathy James H Abey Sally Abheiden Cnh Abhishek A Abiiro Gilbert Abotisem Abitbol Carolyn Ablin Jacob N Abolhassani Nazanin Abou-El-Enein Mohamed Aboumarzouk Omar M Abraha Iosief Abraham Joanna Abrahams-Gessel Shafika Abramson John Abroug Fekri Abu-Raddad Laith Abu-Yaghi Nakhleh E Abu-Zidan Fikri Abughosh Susan Abumuaileq Rami Riziq-Yousef Abuya Timothy Acar M Accordino Federica Acharya Moulinath Acheson Austin Achoki Tom Acker Jason Acosta Stefan Adachi T Adam Ishag Adam Mary Adam Safwaan Adami Gian Adamik Barbara Adams Brian Adams J Adams Lisa V Addis Antonio Addo Juliet Adebajo Ade Adegbija Odewumi Adegboye Oyelola Adelman Eric Adelman Ronald Adeloye Davies Adeniyi Oladele Vincent Adewuya Abiodun Adhikari Neill Adisa Rasaq Adkoli Bv Adler Alma Adolfsson L Adriaanse Marcel Adriaenssens Jef Afifi Abdelmonem Agarwal Mukesh Agarwal Seema Ageberg Eva Agel Julie Agius Paul Agner Tove Agnew Cakil Agogo George Agoritsas Thomas Agosto Caterina Agrawal Sahil Agrawal Sutapa Aguiar Magda Aguilar Ferrandiz Encarnacion Aguilar C Agulnik Asya Agustí Benito Cristina Agyemang Charles Agyepong Irene Ahaus Kees Ahlehoff Ole Ahlquist David Ahmed Ali Ahmed Fayyaz Ahmed Khalid Ahmed Samrah Ahn Hanjong Ahrens Katherine Ahuja Kiran Aichele Stephen Aida Jun Aidala Angela Aiga Hirotsugu Aiken Abigail Aiken Catherine Aitken Leanne Aitken Stuart Ajani Andrew Ajili Faouzia Akano Obinna Akay Serhat Akchurin Oleh Akdemir Nesibe Akem Dimala Christian Akins Ralitsa Akinyemi J Akman Mehmet Akmatov Manas Akparibo Robert Akram Umair Aksoy Mehmet Al Sayah Fatima Al-Gobari Muaamar Al-Hasan Majdi N Al-Hendy Ayman Al-Jefout Moamar Al-Khaled M Al-Naggar Redhwan Ahmed Al-Okka Randa Al-Sughayer Mona Al-Tannir Mohamad Al-Wazaify Mayyada Aladeniyi Isaac Alali Aziz Alamgir Hasanat Alamian Arsham Alamri Y Alanio A Alarcon Walter Alba Carolina Albarqouni Loai Alberici Federico Alberti Hugh Albor Christo Albritton Karen Alderson Sarah Ale Olagoke Aleksandrova Krasimira Alemi Qais Alene Kefyalew Addis Aletras Vassilios Alfieri Alex Ali Mohammed Sanni Ali Huma Ali Iftikhar Ali Raghib Alimoglu Orhan Alisic Eva Alizadeh Mohammad Aljameel Albandary Alkhatib Ahmad Allamani Allaman Allebeck Peter Allem Jon-Patrick Allen Andrew Allen C Allen Isabel Allen Kerry Allgar Victoria Allman-Farinelli Margaret Allwright Shane Almadi T Almasi-Hashiani Amir Almasri Jehad Almdal Thomas Almeda Ortega Jesús Almeida João Almendra Ricardo Almirall José Alonso Wladimir Alouini S Alpizar-Rodriguez D Alpsoy Erkan Alshaikh M Alshehri Mansour Alterman Ron L Althabe F Altman B Altman Donald S Altobelli Emma Altuğ Filiz Alvarez-Alvarez I Álvarez-Bueno Celia Alvarez-Moya Eva Alves Elisabete Alves João Aly Markus Alzahrani Musa Alzahrani Sami Amar David Ambresin Gilles Ambroggio Lilliam Ambrosio Giuseppe Ambrosy Andrew Amianto Federico Amin Nordin Syafinaz Amin Hardik Aminde Leopold Amir Lisa Amir Yufitriana Amiri Motasahm Amital Howard Amland R Ammirati E Amoah Padmore Amoaku W Ampat George Amugsi Dickson Anaf Julia Ananiev J Anaya Juan-Manuel Anchala R Andaluz Norberto Andersen Zorana Jovanovic Andersen Anne-Marie Anderson Annie Anderson Craig Anderson Emma Louise Anderson Fm Anderson Kristen Anderson Peter Anderson Vivki Andersson Thomas Andò Giuseppe Andrade Ortega Juan Alfonso Andrasik Mp Andre Florian Andreassen Bettina Kulle Andreassi MG Andreassi Maria Andreeva Tatiana Andrew Michael Andrews Nicole Andrews S Andriessen K Andriessen Karl Ang Pei Angele Mk Angelillo Italo F Angell Blake Angelucci E Angerud Kh Angioi Manuela Anil S Animaw Worku Anota Amélie Anothaisintawee Thunyarat Anpalahan Mahesan Ansa Benjamin Ansah John Ansari Nasratullah Anselmi Laura Ansmann Lena Anstice Nicola Anthony Jim Anttonen Vuokko Antunes J Anty Rodolphe Anutrakulchai Sirirat Aoun Bahous S Apollonio Dorothy Appelbaum Paul S Appelqvist-Schmidlechner Kaija Appiah Duke Apps Lindsay Apps Michael Arai L Arandjelović Ognjen Arato Teruyo Araújo J Araújo Carla Arbel Ronen Arber Anne Arbo Antonio Arbon Paul Arbustini Eloisa Archer Julian Archibald Daryll Arcos Estela Arday David Ardern Chris Ardern Cl Arditi Chantal Aregbesola Alex Arem Hannah Aremu Olatunde Ariake Kyohei Arim Rubab Arima Kazuhiko Arimoto Takanori Aris Izzuddin Bin Mohd Ariyoshi Koya Arkema Elizabeth Arliani Gustavo Armstrong Ben Armstrong Gail Armstrong Mary Anne Armstrong Mj Armstrong Rebecca Arnal Jean-Michel Arnaout Maha Arnedo-Pena Alberto Arnet Isabelle Arnetz Bengt Arnetz Judy Arnold-Reed Diane Arnold W David Aro Arja Aromataris Edoardo Arora Rakesh C Arora Rc Arslan Mustafa Arthur Eric Artus Majid Arulkumaran Nish Arundell Lauren Arvay Melissa Aryal Kk Asai T Asaithambi Ganesh Asakawa Tetsuya Ascione Raimondo Ashby Sue Asher Elad Asher M Ashleigh Raymond Ashorn Ulla Ashurst John Asiki Gershim Askim Torunn Aslani Parisa Aspinall Peter Assari Shervin Assi Valentina Assis David Astbury Nerys Asthworth Mark Aswathikutty Aswathikutty Asztalos E Atchison Kathryn Atherton Helen Athyros Vasilios Atkinson David Atkinson Greg Atkinson Mark Atnurkar Kishore Atroshi Isam Attai Dj Aubin Henri-Jean Auchincloss Amy Audibert Martine Auer Johann Auf Rehab August Furaha Aune Dagfinn Aung Eindra Aung Koko Aung Myo Nyein Autier Philippe Aveline C Avent Minyon Avery Amanda Avery Ann Avery Anthony Avery Pj Avidan Michael Avidan Michael Awad H Awaisu Ahmed Awasthi Shally Awua Adolf Kofi Ayala Marcelo Ayar Hayat Ayele Dg Ayeni Olufemi Ayeni Olufemi R Ayis Salma Aylin Paul Ayling Kieran Ayonrinde Oyekoya Aypak Cenk Azab Noha A Azer Samy Azim T Aziz W Azuma Kenichi Baade Peter Baalbergen Astrid Baba Kyoko Baba Masaru Babatunde Opeyemi Babson Ka Babu Giridhara R Baburdieri Sergio Bach Bo Bacharova L Bachelot T Bachkati Kristine Bacon Paul Badger G Badia X Badri Shirinsadat Badrick Ellena Badrick Tony Badry De Bae Jong-Myon Baekgaard Niels Baena-Cañada José Baessler Kaven Bagby Michael Bagga A Baghaei Roshanak Bagnasco Annamaria Bahat G Bahner David Bahr Mark Bahwere Paluku Bai Ge Baidal Jennifer Woo Baig Faraz A Bailey-Davis Lisa Bailey A Bailey Catherine Bailey Douggl Bailey Helen Bailey Nick Bailey Patricia Bailey Sarah Lou Bailey Tessa Bain Re Bain Stephen Bainbridge Chris Bainbridge Daniel Bainbridge Kathleen Bainbridge Lesley Baines Cornelia Baird Anne Marie Baishnab E Bakal Jeffrey Baker Andrew Baker Dian L Baker Joshua Baker Joshua F Baker Kevin Baker Md Baker Nancy Baker Paul Baker Richard Baker Ross Bakhturidze George Bakibinga Pauline Bakker David Bakker Marian Balami Joyce Balas Andrew Baldari Carlo Baldassarre Fulvia Baldi Enrico Baldwin Christine Baldwin Constance Baldwin David Balevi Ben Balhara Yatan Balieva F Ball Geoff Ball Ian Balmer Jt Balogun Saliu Balzer Laura Banac Srdan Banach Maciej Banaszak-Holl Jane Bandara Dinusha Banerjee Amitava Banerjee I Banerjee Kushal Banerjee Samprit Baneshi Mohammad Reza Banfai B Bangalore Sripal Bangpan Mukdarut Banham David Bankir Lise Banks Jonathan Banning M Bannister-Tyrrell Melanie Banovic Marko Bansal Aarti Bansal Dipika Banzi Rita Bao Yp Bao Yuqian Baquero Daniel Bar Zeev Yael Bara David Baradaran Hamid Reza Barajas-Nava Leticia Barallat Eva Baranov Anton Barba Carmen Barbar Foss Kim Barbara C Barbati Giulia Barber Matthew Barber Philip Barber S Barbosa Ana Barbouni Anastasia Barcenas Ch Barchi Leandro Barco Stefano Barcz Ewa Bardou Marc Barer David Barger Brian Barger Kathryn Barger Steven Barham-Brown Hannah Barili Fabio Barker Karen Barker Mary Barker Victoria Barkham Michael Barlow William Barnard Kath Barnes Deborah Barnes Geoffrey Barnes Hilary Barnes Mary Barnett Adrian Barnett Carolina Barnett Lauren Barnett Michael Barnett Paul Barnett Stephen Barnicot Kirsten Barnoya Joaquin Baron Emily Baron Murray Barone Mauro Baroni Bruno Barons Martine Barrera Saldaña Hugo Barreto Philipe Barrett Drue Barrett Peter Barrett Sheila Barros De Oliveira Sa Michel Pompeu Barsanti Sara Barshes Nr Barski D Bart Gb Barth Juergen Bartlett Ah Barton James C Bartys Serena Barzilay Joshua Bas-Sarmiento P Basak Ram Bashford Tom Baskar Rajamanickam Basnet Sudha Bass John L Bassand Jean-Pierre Bassano Carlo Bassett-Gunter Rebecca Bassetti Stefano Basso Sm Bassols Judit Bast Lotus Basta Giuseppina Bastiampillai Tarun Bastiani L Baston Cameron Bastuji-Garin Sylvie Basu Anna Basu Naren Bataille Veronique Bateman Nick Bateni Hamid Batista Ricardo Batsis John A Battaglia Salvatore Battaloglu Bektas Batterham Alan Batterham Philip Battersby Cheryl Battista Ra Batty David Batura Neha Bauer Brent Bauer Jan Bauer Stuart Baulig Christine Baum Michael Bauman Adrian Baumeister David Baussano Iacopo Bauwens Jorgen Bavendiek Udo Baxi Shrujal Baxter Nancy Baxter Ruth Bayarsaikhan Dorjsuren Baydemir Canan Baye K Bayer Tony Baylan Satu Bayley Julie Bayman Emine Baynes Habtamu Bayram A Baysari Mt Bazzano Alessandra Beadsworth Mb Beal Matt Beale Anna Beales Darren Beard Renee Bearden David R Beaton Andrea Beattie Bryan Beaudart Charlotte Beaudoin Francesca L Beaulieu Marie-Dominique Beaumont J Beavers Dp Bebell Lm Becher Jg Beck Ben Becker Annette Becker Christian Becker Christine Becker Soeren Becker Torben Beckman Anders Beckman Linda Beckman Thomas Beddoe Liz Bedi S Beeken Rebecca Beerman Stephen Beets Michael Beg Mirza Begg Alan Beghi Massimiliano Behanova Martina Behera Arunanshu Behmanesh Fereshteh Behrens Thomas Beige Joachim Beijamini F Beike Dr Beilby Justin Beiles Charles Beitsch Lm Bekhor Philip Beksinska Mags Belfiore M

BMJ open, 2018-03, Vol.8 (3), p.bmjopen-2018-reviewers

2017 Thank you to our reviewers

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Adenocarcinoma in Situ of the Uterine Cervix—A Systematic Review

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2022-RA-683-ESGO The ENSURE trial for women with early-stage endometrial cancer: A randomized controlled trial comparing the effect of a reduced versus usual follow-up schedule on patient satisfaction...

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Conservative Therapy in Microinvasive Adenocarcinoma of the Uterine Cervix is Justified: An Analysis of 59 Cases and a Review of the Literature

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2017 Thank you to our reviewers

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