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Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells
Author / Creator:Martín-Maestro, Patricia ; Sproul, Andrew ; Martinez, Hector ; Paquet, Dominik ; Gerges, Meri ; Noggle, Scott ; Starkov, Anatoly A.
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2019-12, Vol.56 (12), p.8220-8236
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Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation
Author / Creator:Dheer, Yogita ; Chitranshi, Nitin ; Gupta, Veer ; Abbasi, Mojdeh ; Mirzaei, Mehdi ; You, Yuyi ; Chung, Roger ; Graham, Stuart L. ; Gupta, Vivek
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2018-12, Vol.55 (12), p.9043-9056
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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study
Author / Creator:Brown, J William L ; Cunniffe, Nick G ; Prados, Ferran ; Kanber, Baris ; Jones, Joanne L ; Needham, Edward ; Georgieva, Zoya ; Rog, David ; Pearson, Owen R ; Overell, James ; MacManus, David ; Samson, Rebecca S ; Stutters, Jonathan ; ffrench-Constant, Charles ; Gandini Wheeler-Kingshott, Claudia A M ; Moran, Carla ; Flynn, Paul D ; Michell, Andrew W ; Franklin, Robin J M ; Chandran, Siddharthan ; Altmann, Daniel R ; Chard, Declan T ; Connick, Peter ; Coles, Alasdair J
Publisher:England: Elsevier Ltd
Journal title:Lancet neurology, 2021-09, Vol.20 (9), p.709-720
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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
Author / Creator:Ruggeri, Francesco Simone ; Habchi, Johnny ; Chia, Sean ; Horne, Robert I. ; Vendruscolo, Michele ; Knowles, Tuomas P. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.688-9, Article 688
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Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats
Author / Creator:Zuo, Yuchun ; Huang, Lei ; Enkhjargal, Budbazar ; Xu, Weilin ; Umut, Ocak ; Travis, Zachary D ; Zhang, Guangyu ; Tang, Jiping ; Liu, Fei ; Zhang, John H
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2019-02, Vol.16 (1), p.47-15, Article 47
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Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
Author / Creator:Muñoz-Cabrera, Jonathan Mauricio ; Sandoval-Hernández, Adrián Gabriel ; Niño, Andrea ; Báez, Tatiana ; Bustos-Rangel, Angie ; Cardona-Gómez, Gloria Patricia ; Múnera, Alejandro ; Arboleda, Gonzalo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019, Vol.14 (10), p.e0223578-e0223578
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Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1
Author / Creator:Feng, Haoshen ; Li, Zhe ; Zheng, Rui
Publisher:England: BioMed Central
Journal title:Respiratory research, 2024-12, Vol.25 (1), p.431-14, Article 431
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An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene
Author / Creator:Jurutka, Peter W ; di Martino, Orsola ; Reshi, Sabeeha ; Mallick, Sanchita ; Sausedo, Michael A ; Moen, Grant A ; Lee, Isaac J ; Ivan, Dominic J ; Krall, Tyler D ; Peoples, Samuel J ; Perez, Anthony ; Tromba, Lucas ; Le, Anh ; Khadka, Iraj ; Petros, Ryan ; Savage, Brianna M ; Salama, Eleine ; Salama, Jakline ; Ziller, Joseph W ; Noh, Youngbin ; Lee, Ming-Yue ; Liu, Wei ; Welch, John S ; Marshall, Pamela A ; Wagner, Carl E
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-12, Vol.23 (24), p.16213
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Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression
Author / Creator:Hu, Linyi ; Sun, Yin ; Luo, Jie ; He, Xiang ; Ye, Meihua ; Li, Gonghui ; Zhang, Yong ; Bai, Jian ; Zhang, Dahong ; Chang, Chawnshang
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2020-02, Vol.39 (9), p.1891-1903
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Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway
Author / Creator:Ai, Xinghao ; Mao, Feng ; Shen, Shengping ; Shentu, Yang ; Wang, Jiejun ; Lu, Shun
Publisher:England: BioMed Central
Journal title:BMC cancer, 2018-04, Vol.18 (1), p.407-407, Article 407
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The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer
Author / Creator:Moerland, Jessica A. ; Zhang, Di ; Reich, Lyndsey A. ; Carapellucci, Sarah ; Lockwood, Beth ; Leal, Ana S. ; Krieger-Burke, Teresa ; Aleiwi, Bilal ; Ellsworth, Edmund ; Liby, Karen T.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-12, Vol.10 (1), p.22244-16, Article 22244
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Remyelination varies between and within lesions in multiple sclerosis following bexarotene
Author / Creator:Brown, J. William L. ; Prados, Ferran ; Altmann, Daniel R. ; Kanber, Baris ; Stutters, Jonathan ; Cunniffe, Nick G. ; Jones, Joanne L. ; Georgieva, Zoya G. ; Needham, Edward J. ; Daruwalla, Cyrus ; Wheeler‐Kingshott, Claudia Gandini ; Connick, Peter ; Chandran, Siddharthan ; Franklin, Robin ; MacManus, David ; Samson, Rebecca ; Coles, Alasdair ; Chard, Declan
Publisher:United States: John Wiley & Sons, Inc
Journal title:Annals of clinical and translational neurology, 2022-10, Vol.9 (10), p.1626-1642
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Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage
Author / Creator:Yuan, Chunling ; Dai, Chunmei ; Li, Ziqiang ; Zheng, Li ; Zhao, Miaoxin ; Dong, Sumin
Publisher:New York: Springer US
Journal title:Neurochemical research, 2020-07, Vol.45 (7), p.1500-1509
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ArticlesPeer ReviewedFull Text
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexa...
Author / Creator:Jurutka, Peter W ; di Martino, Orsola ; Reshi, Sabeeha ; Mallick, Sanchita ; Sabir, Zhela L ; Staniszewski, Lech J P ; Warda, Ankedo ; Maiorella, Emma L ; Minasian, Ani ; Davidson, Jesse ; Ibrahim, Samir J ; Raban, San ; Haddad, Dena ; Khamisi, Madleen ; Suban, Stephanie L ; Dawson, Bradley J ; Candia, Riley ; Ziller, Joseph W ; Lee, Ming-Yue ; Liu, Chang ; Liu, Wei ; Marshall, Pamela A ; Welch, John S ; Wagner, Carl E
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-11, Vol.22 (22), p.12371
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Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells
Author / Creator:Osei-Sarfo, Kwame ; Gudas, Lorraine J
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-04, Vol.14 (4), p.e0215234
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Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protectıve Agent on Rat Synaptosomes Treated with Aβ(1-42)
Author / Creator:Hacioglu, Ceyhan ; Kar, Fatih ; Kanbak, Gungor
Publisher:New York: Springer US
Journal title:Neurochemical research, 2021-04, Vol.46 (4), p.804-818
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Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis
Author / Creator:Kasheke, Gracious D S ; Hendy, Basmah A M ; Dorighello, Gabriel G ; Uccelli, Nonthué A ; Gothié, Jean-David M ; Novorolsky, Robyn J ; Oulton, Madison J ; Asainayagam, Jude ; Makarov, Adam I ; Fraser, Kaitlyn S ; Vuligonda, Vidyasagar ; Sanders, Martin E ; Kennedy, Timothy E ; Robertson, George S
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2024-12, Vol.12 (1), p.197-18, Article 197
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Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
Author / Creator:Dobrotkova, Viera ; Chlapek, Petr ; Jezova, Marta ; Adamkova, Katerina ; Mazanek, Pavel ; Sterba, Jaroslav ; Veselska, Renata
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-06, Vol.14 (6), p.e0218269
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Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells
Author / Creator:Doost, Mobin Emran ; Hong, Jennifer ; Broatch, Jennifer E ; Applegate, Michael T ; Wagner, Carl E ; Marshall, Pamela A ; Jurutka, Peter W
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2024-11, Vol.13 (22), p.1878
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Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas
Author / Creator:Warda, Ankedo ; Staniszewski, Lech J P ; Sabir, Zhela ; Livingston, Sarah ; Sausedo, Michael ; Reshi, Sabeeha ; Ron, Eyal ; Applegate, Michael T ; Haddad, Dena ; Khamisi, Madleen ; Marshall, Pamela A ; Wagner, Carl E ; Jurutka, Peter W
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2023-11, Vol.12 (21), p.2575
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Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

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Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

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Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

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Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease

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Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1

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An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene

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Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression

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Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

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The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer

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Remyelination varies between and within lesions in multiple sclerosis following bexarotene

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Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

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Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexa...

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Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells

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Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protectıve Agent on Rat Synaptosomes Treated with Aβ(1-42)

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Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis

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Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers

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Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells

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Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas

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