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Suicides are a leading cause of death in psychiatric patients, and in society at large. Developing more quantitative and objective ways (biomarkers) for predicting and tracking suicidal states would have immediate practical applications and positive societal implications. We undertook such an endeavor. First, building on our previous blood biomarker work in mood disorders and psychosis, we decided to identify blood gene expression biomarkers for suicidality, looking at differential expression of genes in the blood of subjects with a major mood disorder (bipolar disorder), a high-risk population prone to suicidality. We compared no suicidal ideation (SI) states and high SI states using a powerful intrasubject design, as well as an intersubject case–case design, to generate a list of differentially expressed genes. Second, we used a comprehensive Convergent Functional Genomics (CFG) approach to identify and prioritize from the list of differentially expressed gene biomarkers of relevance to suicidality. CFG integrates multiple independent lines of evidence—genetic and functional genomic data—as a Bayesian strategy for identifying and prioritizing findings, reducing the false-positives and false-negatives inherent in each individual approach. Third, we examined whether expression levels of the blood biomarkers identified by us in the live bipolar subject cohort are actually altered in the blood in an age-matched cohort of suicide completers collected from the coroner’s office, and report that 13 out of the 41 top CFG scoring biomarkers (32%) show step-wise significant change from no SI to high SI states, and then to the suicide completers group. Six out of them (15%) remained significant after strict Bonferroni correction for multiple comparisons. Fourth, we show that the blood levels of SAT1 (spermidine/spermine N1–acetyltransferase 1), the top biomarker identified by us, at the time of testing for this study, differentiated future as well as past hospitalizations with suicidality, in a live cohort of bipolar disorder subjects, and exhibited a similar but weaker pattern in a live cohort of psychosis (schizophrenia/schizoaffective disorder) subjects. Three other (phosphatase and tensin homolog (PTEN), myristoylated alanine-rich protein kinase C substrate (MARCKS), and mitogen-activated protein kinase kinase kinase 3 (MAP3K3)) of the six biomarkers that survived Bonferroni correction showed similar but weaker effects. Taken together, the prospective and retrospective hospitalization data suggests SAT1, PTEN, MARCKS and MAP3K3 might be not only state biomarkers but trait biomarkers as well. Fifth, we show how a multi-dimensional approach using SAT1 blood expression levels and two simple visual-analog scales for anxiety and mood enhances predictions of future hospitalizations for suicidality in the bipolar cohort (receiver-operating characteristic curve with area under the curve of 0.813). Of note, this simple approach does not directly ask about SI, which some individuals may deny or choose not to share with clinicians. Lastly, we conducted bioinformatic analyses to identify biological pathways, mechanisms and medication targets. Overall, suicidality may be underlined, at least in part, by biological mechanisms related to stress, inflammation and apoptosis.

Molecular psychiatry, 2013-12, Vol.18 (12), p.1249-1264

Discovery and validation of blood biomarkers for suicidality

Despite the challenge of busy schedules, each supported the critical peer review process that underlies the effective presentation and publication of new work.The Journal of Critical Care acknowledges their valuable contribution and invites their future support.Anuja Abayadeera Saher Abd Elaty Sami Abdellatif Assem Abdel Razek Matthew C. Aboudara Simon Abrams Pedro Abreu-Gonzalez Mahmoud Abu-Shakra Ayhan Acar Adebola Adesanya Patrick Aguilar Hernan Aguirre-Bermeo Nahreen Ahmed Tania Ahuja Juhani Airaksinen Leanne Aitken Laura Akroyd Mahableshwar S. Albur Cesar Aldecoa Matilde Jo Allingstrup Daniel Alonso-Alconada Fernanda Donner Alves Nicolino Ambrosino Angela Amigoni Shahram Amini Yufitriana Amir Karin Amrein Dennis Amundson Mingrui An You-zhong An Vijay G. Anand Claudia Andrade William S. Andereck Jeff Anderson Claudia Andrade Emily Andrew Philip Andrew Sabina Antoniu Kazuyoshi Aoyama Michael April Yaseen Arabi Daniel Arellano Bob Arnold Robert T. Arntfield Rakesh Arora Subhash Arora Rendell Ashton Sven Asmussen Kazuaki Atagi Kamran Athar A. Artigas Nazan Atalan Pascal Augustin Georg Auzinger Zuhal Aykac Tawfik Ayoub Eugenia Ayrian Luciano César Pontes de Azevedo Afzal Azim Elie Azoulay Sean Bagshaw Marika Bajc Andrew Baker Jan Bakker André Balbi Claire Baldwin Michael Baram In Barbash Carolina Barnett Juliana Barr Rafael Barrera Nicholas A. Barrett Bruno U. Baršić Rajit Basu Stefania Battista Tobias Becher Joseph Bednarczyk Martin Beed Randy Scott Bell François Beloncle Anita Bemis-Dougherty Dan Benhamou Peyman Benharash Lars Berggren Samarth Beri Jesus F. Bermejo-Martin Enrique Bernal Morell Michael Bernhard Sue Berney Andrew Bersten Kristina Betters Satish Bhagwanjee Jaspreet Bhangu Adarsh Bhimraj Kirankumar Bhosrekar Shailesh Bihari Edward Bittner Einar Bjornsson Adarsh Bhimraj Kirankumar Bhosrekar Shailesh Bihari Edward Bittner Kevin Blaine Michael Blaivas lluis Blanch Anabel Blasi Eike Blohm Frank Bloos Leanne Boehm Jerina Boelens Suzana Bojic Scott Bolesta Pieter Bothma Arne Böttcher Omar Bouamra Josee Bouchard Belaid Bouhemad Sandra Braaf Richard Branson Mario Brasse Jeffrey Brent Arturu Briva Thomas V. Brogan Steven Brooks Evgeni Brotfain Sydney E.S. Brown Sorin Brull Mitchell Buckley Lukas Buendgens Mehtap Bulut Christina Burger Aidan Burrell Chris Burtin Katharina Busl Claudia Raquel Bustamante-Troncoso Yasin Cakilli Philip Calder Charles Caldwell Clifton W. Callaway Carlos Camargo Enrico Camporesi Van Mai Ai Cao-Lormeau Gilles Capellier Nicholas Caputo M. Capuzzo Louanne Carabini Danilo Cardim Pablo Cardinal-Fernández Bernard Carroll Gail Carson Andrew Casamento Jonathan Casey Diego Castanares-Zapatero Gaud Catho Alexandre Cavalcanti Rodrigo Cavallazzi Christopher Celano Maurizio Cereda Onuma Chaiwat Donald Chalfin Howard Champion Cherylee Chang Dong-Seon Chang Clarence Chant Emmanuelle Charbonney Jean Charchaflieh Manu Chaudhary Erzhen Chen Jack Chen Jian Chen Liang-Kung Chen Lujie Chen Xiaodong Chen Yih-Sharng Chen Thomas Cherpanath Sanjeev Chhangani Davide Chiumello Young-Jae Cho Karen Choong Vineet Chopra Jason Christie Kenneth Christopher Carl Chudnofsky Melissa Chudow Chi Ryang Chung Matthew M. Churpek Aydin Ciledag Catia Cilloniz Theodora Claushuis Gilles Clermont John Clochesy N. Cobos-Trigueros John Como Bronwen Connolly Aaron Cook Craig Coopersmith Roberto Copetti Thiago Corrêa Gerard Cortina Deena Costa Jill Cox Angel Coz-Yataco David Crippen Roselle Crombie Tobias Cronberg Maria Cronhjort Brian Cuthbertson Marek Czosnyka Wojciech Dabrowski Mitchell J. Daley Lidia Dalfino Felipe Dal-Pizzol Stephanie Dancer Pierre-Eric Danin Saurabh Das Paulo Sergio Lucas da Silva Joseph Dasta John Davies Eric Deflandre Thais de la Cruz Jean Dellamonica Antonio Dell'Anna Christian Delles Richard Dellinger Mauricio Del Rio Lorenzo Del Sorbo Alexandre Demoule Jou-Fang Deng Bart Depreitere Nicolas de Prost Stan Deresinski Kurt Derfler Girish Deshpande Michael Detsky Matthew Dettmer Felippe Dexheimer Neto Kiran Dhanireddy Shekhar Dhanvijay Sanjar Dhar Janet Diaz Yalim Dikmen George Dimopoulos Mario Di Napoli Ener Cagri Dinleyici Salvatore di Somma Lisa Diamond George Djaiani Thomas Dodds Suhail Doi Stephanie Doniger John Donnelly Todd Dorman Gertjan Driessen Xavier Drouot Byron C. Drumheller Bin Du Martin Dünser Daniel Dürr Frantisek Duska Amy Dzierba Tobias Eckle Michael Eddleston Jeff Edwards Philip A. Efron Moritoki Egi Joachim Ehrlich Janeth Ejike Bulent Elbasan John Elfar Nader Elgamal Gunnar Elke Hatem Abo Elwafa Karen Kim Embrey Heidi Engel Åsa Engström Aaron Enten Ali Erdem Michael Erdman Natalie Ernecoff Jose Luis Escalante Sandrine Essouri Dean Eurich Aristomenis Exadaktylos Diego Falci Vassilios Fanos Mohammad Fararouei Csaba Feher Rafael Fernandez Ana Fernandez-Bustamante Miguel Ferrer Eberval Figueiredo D. Clark Files Guido Filler James Fink Fulvio Fiorini Carl-Ludwig Fischer-Fröhlich Mark Fitzgerald Hans Flaatten Friedrich Flachsbart Fernando Fleischman Heidi Flori Moshe Flugelman Robert Fowler Joshua D. Fox Alison Fox-Robichaud Dustin Fraidenburg Heidi Frankel Amy Freeman-Sanderson Yonathan Freund Tracy Friedlander Gilberto Friedman Valentin Fuhrmann Hidetada Fukushima Georg-Christian Funk Manuel Ignacio Monge GarcÌa Shruti Gadre Jane P. Gagliardi Colleen Gallagher Romayne Gallagher Marc Garnier Shiekh Gazalla Raul Gazmuri Brian Gehlbach Corinna Geisler Geza Gemes Anthony Gerlach Maher Ghamloush Evangelos Giamarellos-Bourboulis Steven Giannotta Lawrence Gillman Donald Glower Alberto Goffi Funda Gok Brahm Goldstein Evan C. Goligher Thomas Golper Hernando Gomez Angela Gomez-Simmonds Oleg Gorelik Rik Gosselink Marcin Grabowski David Graham Michael Grant Jaime Gray Cameron Green David Matthew Greer Russell Griffin Peter Gruen Danielle Gualandro Claude Guerin C. Guervilly Bertrand Guidet Pierre-Grégaire Guinot Faheem Guirgis Albrecht Günther Punkaj Gupta Mohan Gurjar Cristina Gutierrez Goksel Guven Sandra Ha Lawrence Haber Marit Habicher Johannes Hadem Muhammd Hadi Ludmilla Hajjar K. Haley Ozlem Asmaz Haliloğlu Leslie Hamilton Drayton Hammond Laura Hawryluck Mohammad Reza Hajiesmaeili Kimberley J. Haines K Haley Ozlem Asmaz Haliloğlu Thomas Hall Sophie Hamada Leslie Hamilton Dong Han Brian Harbrecht Chris Harvey Satoru Hashimoto Gil Hardy Steve Harris Meg Harrold Maurene Harvey Ali Hasan Johanna Hastbacka Laura Hawryluck Mineji Hayakawa Kei Hayashida Kan He Donagh Healy Stephen Heard Peter D. Hebbard Alan Heffner Guillaume Hékimian Jean Henrion Gonzalo Hernandez David Herndon Jean Henrion Michael Hermon Shoshana Herzig Jonathan Hiatt Melissa Hines Kwok Ming Ho Andreas Hoeft Leslie Hoffman Michael Holick Michitaka Honda Sang-Bum Hong Patrick Honore Ramona Hopkins Sumedh Hoskote Leila Hosseinian May Hua Markus Huber-Lang Jana Hudcova Christopher G. Hughes Mina Hur William Hurford James Hurley Benedikt Huttner Joseph Hyder Cameron D. Hypes Toshiaki Iba Irwani Ibrahim Takehiko Iijima Michael Imhoff Can Ince Francesca Innocenti Shigeaki Inoue Elias Iosifidis Giorgio Antonio Iotti Masao Iwagami James C. Jackson Shevin Jacob Judith Jacobi Rita J. Jacobs Augustina Jankauskiene Arun Jayaraman Jacob Jentzer Edgar Jimenez Pranesh Jogia Pär Ingemar Johansson Jennie J. Johnstone Sarah Jolley Christina Jones Daryl Jones Emma Lucy Joynes Paul Juang Saraswati Kache Robert Kacmarek Magnus Kaffarnik Alisan Kahraman Bernd Kaina Pierre Kalfon Richard H. Kallet K. Y. Ronald Kam Biren Kamdar Sandra Kane-Gill Tadashi Kaneko Kawamae Kaneyuki Yan Kang Zlatka Kanic Dimitrios Karakitsos Jiri Karasek Lioudmila Karnatovskaia Shunji Kasaoka Rahul Kashyap Hans Katzberg John Kellett Justin Kenardy Michael Kenes Nancy Kentish-Barnes Babar Khan Rumi Khan Ashish Khanna Michelle Kho Bodin Khwannimit Martin A. Kiernan Keith Killu Jeong Lan Kim Minyoung Kim Cenk Kirakli Emrys Kirkman Roxanne Kirsch Kento Kitada Bengt Klarin Patrycja Kleczkowska Ruth Kleinpell Peter M. C. Klein Klouwenberg Michael Klompas Melissa Knauert Wolfram Trudo Knoefel Hitoshi Kobata Leslie Kobayashi Younsuck Koh Marin H. Kollef Eumorfia Kondili John Kortbeek Pierre Kory Yoshifumi Kotake Despoina Koulenti Jay Koyner Roman Kozlov Robert Kramer Jeffrey Kraut Marian Krawczyk Miltiadis Krokidis Sapna Kudchadkar Ernst Johan Kuipers Ayush Kumar Gagan Kumar Virender Kumar Atike Tekeli Kunt Yasuhiro Kuroda Murat Kürtüncü Shigeki Kushimoto Catherine Kuza Arthur Kwizera Kathryn Kynoch Anja Kathrin Jaehne Randeep Jawa Marc Jeschke Bruce Johnson Christina Jones Paul Juang John Laffey Rajiv P. Lahiri Jean-Daniel Lalau Yoan Lamarche Lionel Lamhaut Francois Lamontagne Marcus Lancé Giora Landesberg Giovanni Landoni Meghan B. Lane-Fall James Lantry Gaetano Lapichino Fin Stolze Larsen Heath Latham Alexander Lauten Carl Lavie Christos Lazaridis ByungKook Lee Dong Hoon Lee Francis Lee Jean-Yves Lefrant Frans Leijten Kay Leissner Aleksandra Leligdowicz Virginie Lemiale Ricardo León De La Fuente Marc Leone Nicolas Lerolle Olivier Leroy Ganjana Lertmemongkolchai O. Lesur Hayley Louise Letson Marcel M. Levi Alexander B. Levitov Christopher Lewandowski Tyler Lewis Karl Lhotta Chunsheng Li Junhui Li Xue-fei Li Amy Liepert Chae-Man Lim Kaustubh Limaye Wei-Chieh Lin Yichun Lin Bengt Lindholm Angela Lipshutz Thiago Lisboa Gregory R. Lisciandro Steven Lisco Changting Liu Hong Liu Linda Liu Ping Liu K. Lobdell Suzana Lobo Nazir Lone José Lorente Vladimir Lomivorotov Nazir Lone Federico Longhini Erin Lowery Qin Lu Xiaocheng Lu Felipe Lucena Peter Luedike Carlos Marcelo Luna Jun Ma Neil MacIntyre Kate Madden Rama K. Maganti Sheldon Magder Aly Mageed Khalid A. Maghrabi Shelley Magill Laura Magrini Malcolm Mahadevan Ata Mahmoodpoor Charles Mains Harufumi Maki Demosthenes Makris Manu Malbrain Michael Malcharek Vinicius Maldaner Mark A. Malesker Jihad Mallat Fermin Mallor Ainsley Malone Gerard Manecke Nilam Mangalmurti Joseph C. Manning Constantine Manthous William Manzanares Ann Manzardo Paul Marik John Marini Nicolas Marjanovic Jonothan Mark Barry Markovitz Regan Marsh John Marshall Rosemary Mar

Journal of critical care, 2018-04, Vol.44, p.450-458

2017 reviewers

Translation of research to practice often needs intermediaries to help the process occur. Our Prevention Research Center has identified a total of 89 residents of public housing in the last 11 years who have been working in the Resident Health Advocate (RHA) program to engage residents in improving their own and other residents’ health status by becoming trained in skills needed by community health workers. Future directions include training for teens to become Teen RHAs and further integration of our RHA program with changes in the health care system and in the roles of community health workers in general.

Family & community health, 2015-04, Vol.38 (2), p.141-148

Resident Health Advocates in Public Housing Family Developments

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Discovery and validation of blood biomarkers for suicidality

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2017 reviewers

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Resident Health Advocates in Public Housing Family Developments

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