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ArticlesPeer ReviewedFull Text
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
Author / Creator:McBrien, Julia Bergild ; Mavigner, Maud ; Franchitti, Lavinia ; Smith, S. Abigail ; White, Erick ; Tharp, Gregory K. ; Walum, Hasse ; Busman-Sahay, Kathleen ; Aguilera-Sandoval, Christian R. ; Thayer, William O. ; Spagnuolo, Rae Ann ; Kovarova, Martina ; Wahl, Angela ; Cervasi, Barbara ; Margolis, David M. ; Vanderford, Thomas H. ; Carnathan, Diane G. ; Paiardini, Mirko ; Lifson, Jeffrey D. ; Lee, John H. ; Safrit, Jeffrey T. ; Bosinger, Steven E. ; Estes, Jacob D. ; Derdeyn, Cynthia A. ; Garcia, J. Victor ; Kulpa, Deanna A. ; Chahroudi, Ann ; Silvestri, Guido
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-02, Vol.578 (7793), p.154-159
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Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Author / Creator:Arunachalam, Prabhu S. ; Scott, Madeleine K. D. ; Hagan, Thomas ; Li, Chunfeng ; Feng, Yupeng ; Wimmers, Florian ; Grigoryan, Lilit ; Trisal, Meera ; Edara, Venkata Viswanadh ; Lai, Lilin ; Chang, Sarah Esther ; Feng, Allan ; Dhingra, Shaurya ; Shah, Mihir ; Lee, Alexandra S. ; Chinthrajah, Sharon ; Sindher, Sayantani B. ; Mallajosyula, Vamsee ; Gao, Fei ; Sigal, Natalia ; Kowli, Sangeeta ; Gupta, Sheena ; Pellegrini, Kathryn ; Tharp, Gregory ; Maysel-Auslender, Sofia ; Hamilton, Sydney ; Aoued, Hadj ; Hrusovsky, Kevin ; Roskey, Mark ; Bosinger, Steven E. ; Maecker, Holden T. ; Boyd, Scott D. ; Davis, Mark M. ; Utz, Paul J. ; Suthar, Mehul S. ; Khatri, Purvesh ; Nadeau, Kari C. ; Pulendran, Bali
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-08, Vol.596 (7872), p.410-416
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Natural SIV Hosts: Showing AIDS the Door
Author / Creator:Chahroudi, Ann ; Bosinger, Steven E. ; Vanderford, Thomas H. ; Paiardini, Mirko ; Silvestri, Guido
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-03, Vol.335 (6073), p.1188-1193
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Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription
Author / Creator:Zanoni, Michelle ; Palesch, David ; Pinacchio, Claudia ; Statzu, Maura ; Tharp, Gregory K. ; Paiardini, Mirko ; Chahroudi, Ann ; Bosinger, Steven E. ; Yoon, Jack ; Cox, Bryan ; Silvestri, Guido ; Kulpa, Deanna A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2020-09, Vol.16 (9), p.e1008821-e1008821
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Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques
Author / Creator:Manickam, Cordelia ; Upadhyay, Amit A. ; Woolley, Griffin ; Kroll, Kyle W. ; Terry, Karen ; Broedlow, Courtney A. ; Klatt, Nichole R. ; Bosinger, Steven E. ; Reeves, R. Keith
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2024-05, Vol.20 (5), p.e1012223-e1012223
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Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood
Author / Creator:Nakaya, Helder I. ; Clutterbuck, Elizabeth ; Kazmin, Dmitri ; Wang, Lili ; Cortese, Mario ; Bosinger, Steven E. ; Patel, Nirav B. ; Zak, Daniel E. ; Aderem, Alan ; Dong, Tao ; Del Giudice, Giuseppe ; Rappuoli, Rino ; Cerundolo, Vincenzo ; Pollard, Andrew J. ; Pulendran, Bali ; Siegrist, Claire-Anne
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1853-1858
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Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
Author / Creator:Nixon, Christopher C. ; Mavigner, Maud ; Sampey, Gavin C. ; Brooks, Alyssa D. ; Spagnuolo, Rae Ann ; Irlbeck, David M. ; Mattingly, Cameron ; Ho, Phong T. ; Schoof, Nils ; Cammon, Corinne G. ; Tharp, Greg K. ; Kanke, Matthew ; Wang, Zhang ; Cleary, Rachel A. ; Upadhyay, Amit A. ; De, Chandrav ; Wills, Saintedym R. ; Falcinelli, Shane D. ; Galardi, Cristin ; Walum, Hasse ; Schramm, Nathaniel J. ; Deutsch, Jennifer ; Lifson, Jeffrey D. ; Fennessey, Christine M. ; Keele, Brandon F. ; Jean, Sherrie ; Maguire, Sean ; Liao, Baolin ; Browne, Edward P. ; Ferris, Robert G. ; Brehm, Jessica H. ; Favre, David ; Vanderford, Thomas H. ; Bosinger, Steven E. ; Jones, Corbin D. ; Routy, Jean-Pierre ; Archin, Nancie M. ; Margolis, David M. ; Wahl, Angela ; Dunham, Richard M. ; Silvestri, Guido ; Chahroudi, Ann ; Garcia, J. Victor
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-02, Vol.578 (7793), p.160-165
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Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates
Author / Creator:Corry, Jacqueline ; Kettenburg, Gwenddolen ; Upadhyay, Amit A. ; Wallace, Megan ; Marti, Michelle M. ; Wonderlich, Elizabeth R. ; Bissel, Stephanie J. ; Goss, Kyndal ; Sturgeon, Timothy J. ; Watkins, Simon C. ; Reed, Douglas S. ; Bosinger, Steven E. ; Barratt-Boyes, Simon M.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-03, Vol.18 (3), p.e1010395-e1010395
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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques
Author / Creator:Bollimpelli, Venkata S. ; Reddy, Pradeep B. J ; Gangadhara, Sailaja ; Charles, Tysheena P. ; Burton, Samantha L. ; Tharp, Gregory K. ; Styles, Tiffany M. ; Labranche, Celia C. ; Smith, Justin C. ; Upadhyay, Amit A. ; Sahoo, Anusmita ; Legere, Traci ; Shiferaw, Ayalnesh ; Velu, Vijayakumar ; Yu, Tianwei ; Tomai, Mark ; Vasilakos, John ; Kasturi, Sudhir P. ; Shaw, George M. ; Montefiori, David ; Bosinger, Steven E. ; Kozlowski, Pamela A. ; Pulendran, Bali ; Derdeyn, Cynthia A. ; Hunter, Eric ; Amara, Rama R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-08, Vol.14 (1), p.4789-16, Article 4789
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High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope
Author / Creator:Mopuri, Rohini ; Welbourn, Sarah ; Charles, Tysheena ; Ralli-Jain, Pooja ; Rosales, David ; Burton, Samantha ; Aftab, Areeb ; Karunakaran, Kirti ; Pellegrini, Kathryn ; Kilembe, William ; Karita, Etienne ; Gnanakaran, Sandrasegaram ; Upadhyay, Amit A. ; Bosinger, Steven E. ; Derdeyn, Cynthia A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2023-10, Vol.19 (10), p.e1011717-e1011717
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Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques
Author / Creator:Byrnes, Sarah J. ; Busman-Sahay, Kathleen ; Angelovich, Thomas A. ; Younger, Skyler ; Taylor-Brill, Sol ; Nekorchuk, Michael ; Bondoc, Stephen ; Dannay, Rachel ; Terry, Margaret ; Cochrane, Catherine R. ; Jenkins, Trisha A. ; Roche, Michael ; Deleage, Claire ; Bosinger, Steven E. ; Paiardini, Mirko ; Brew, Bruce J. ; Estes, Jacob D. ; Churchill, Melissa J.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2023-03, Vol.19 (3), p.e1011290
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Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection
Author / Creator:Mylvaganam, Geetha H. ; Rios, Daniel ; Abdelaal, Hadia M. ; Iyer, Smita ; Tharp, Gregory ; Mavigner, Maud ; Hicks, Sakeenah ; Chahroudi, Ann ; Ahmed, Rafi ; Bosinger, Steven E. ; Williams, Ifor R. ; Skinner, Pamela J. ; Velu, Vijayakumar ; Amara, Rama R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (8), p.1976-1981
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mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
Author / Creator:Sinclair, Charles ; Bommakanti, Gayathri ; Gardinassi, Luiz ; Loebbermann, Jens ; Johnson, Matthew Joseph ; Hakimpour, Paul ; Hagan, Thomas ; Benitez, Lydia ; Todor, Andrei ; Machiah, Deepa ; Oriss, Timothy ; Ray, Anuradha ; Bosinger, Steven ; Ravindran, Rajesh ; Li, Shuzhao ; Pulendran, Bali
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6355), p.1014-1021
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ArticlesPeer ReviewedFull Text
PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
Author / Creator:Dyavar Shetty, Ravi ; Velu, Vijayakumar ; Titanji, Kehmia ; Bosinger, Steven E. ; Freeman, Gordon J. ; Silvestri, Guido ; Amara, Rama Rao
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2012-05, Vol.122 (5), p.1712-1716
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Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
Author / Creator:Nganou-Makamdop, Krystelle ; Billingsley, James M. ; Yaffe, Zachary ; O’Connor, Gregory ; Tharp, Gregory K. ; Ransier, Amy ; Laboune, Farida ; Matus-Nicodemos, Rodrigo ; Lerner, Andrea ; Gharu, Lavina ; Robertson, Jennifer M. ; Ford, Mandy L. ; Schlapschy, Martin ; Kuhn, Nadine ; Lensch, Alexandra ; Lifson, Jeffrey ; Nason, Martha ; Skerra, Arne ; Schreiber, Gideon ; Bosinger, Steven E. ; Douek, Daniel C.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2018-08, Vol.14 (8), p.e1007246
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Clinical and whole genome characterization of SARS-CoV-2 in India
Author / Creator:Muttineni, Radhakrishna ; Kammili, Nagamani ; Bingi, Thrilok Chander ; Rao M., Raja ; Putty, Kalyani ; Dholaniya, Pankaj Singh ; Puli, Ravi Kumar ; Pakalapati, Sunitha ; S., Saritha ; K., Shekar ; Doodipala, Mallikarjuna Reddy ; Upadhyay, Amit A. ; Bosinger, Steven E. ; Amara, Rama R. ; Kondapi, Anand K.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-02, Vol.16 (2), p.e0246173-e0246173
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ArticlesPeer ReviewedFull Text
Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals
Author / Creator:Klatt, Nichole R. ; Bosinger, Steven E. ; Peck, Melicent ; Richert-Spuhler, Laura E. ; Heigele, Anke ; Gile, Jillian P. ; Patel, Nirav ; Taaffe, Jessica ; Julg, Boris ; Camerini, David ; Torti, Carlo ; Martin, Jeffrey N. ; Deeks, Steven G. ; Sinclair, Elizabeth ; Hecht, Frederick M. ; Lederman, Michael M. ; Paiardini, Mirko ; Kirchhoff, Frank ; Brenchley, Jason M. ; Hunt, Peter W. ; Silvestri, Guido
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2014-08, Vol.10 (8), p.e1004345-e1004345
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ArticlesPeer ReviewedFull Text
Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial
Author / Creator:Balle, Christina ; Konstantinus, Iyaloo N. ; Jaumdally, Shameem Z. ; Havyarimana, Enock ; Lennard, Katie ; Esra, Rachel ; Barnabas, Shaun L. ; Happel, Anna-Ursula ; Moodie, Zoe ; Gill, Katherine ; Pidwell, Tanya ; Karaoz, Ulas ; Brodie, Eoin ; Maseko, Venessa ; Gamieldien, Hoyam ; Bosinger, Steven E. ; Myer, Landon ; Bekker, Linda-Gail ; Passmore, Jo-Ann S. ; Jaspan, Heather B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-11, Vol.11 (1), p.5578-15, Article 5578
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The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
Author / Creator:Strongin, Zachary ; Hoang, Timothy N. ; Tharp, Gregory K. ; Rahmberg, Andrew R. ; Harper, Justin L. ; Nguyen, Kevin ; Franchitti, Lavinia ; Cervasi, Barbara ; Lee, Max ; Zhang, Zhan ; Boritz, Eli A. ; Silvestri, Guido ; Marconi, Vincent C. ; Bosinger, Steven E. ; Brenchley, Jason M. ; Kulpa, Deanna A. ; Paiardini, Mirko
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-07, Vol.18 (7), p.e1010723-e1010723
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A new rhesus macaque assembly and annotation for next-generation sequencing analyses
Author / Creator:Zimin, Aleksey V ; Cornish, Adam S ; Maudhoo, Mnirnal D ; Gibbs, Robert M ; Zhang, Xiongfei ; Pandey, Sanjit ; Meehan, Daniel T ; Wipfler, Kristin ; Bosinger, Steven E ; Johnson, Zachary P ; Tharp, Gregory K ; Marçais, Guillaume ; Roberts, Michael ; Ferguson, Betsy ; Fox, Howard S ; Treangen, Todd ; Salzberg, Steven L ; Yorke, James A ; Norgren, Robert B
Publisher:England: BioMed Central Ltd
Journal title:Biology direct, 2014-10, Vol.9 (1), p.20-20, Article 20
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Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

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Systems vaccinology of the BNT162b2 mRNA vaccine in humans

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Natural SIV Hosts: Showing AIDS the Door

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Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription

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Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques

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Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

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Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

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Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates

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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques

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High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope

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Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

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Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection

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mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

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PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

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Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

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Clinical and whole genome characterization of SARS-CoV-2 in India

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Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

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Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial

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The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence

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A new rhesus macaque assembly and annotation for next-generation sequencing analyses

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