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ArticlesPeer ReviewedFull Text
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
Author / Creator:Sey, Nancy Y. A. ; Hu, Benxia ; Mah, Won ; Fauni, Harper ; McAfee, Jessica Caitlin ; Rajarajan, Prashanth ; Brennand, Kristen J. ; Akbarian, Schahram ; Won, Hyejung
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2020-04, Vol.23 (4), p.583-593
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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Author / Creator:Xu, Miao ; Lee, Emily M ; Wen, Zhexing ; Cheng, Yichen ; Huang, Wei-Kai ; Qian, Xuyu ; TCW, Julia ; Kouznetsova, Jennifer ; Ogden, Sarah C ; Hammack, Christy ; Jacob, Fadi ; Nguyen, Ha Nam ; Itkin, Misha ; Hanna, Catherine ; Shinn, Paul ; Allen, Chase ; Michael, Samuel G ; Simeonov, Anton ; Huang, Wenwei ; Christian, Kimberly M ; Goate, Alison ; Brennand, Kristen J ; Huang, Ruili ; Xia, Menghang ; Ming, Guo-li ; Zheng, Wei ; Song, Hongjun ; Tang, Hengli
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-10, Vol.22 (10), p.1101-1107
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Synergistic effects of common schizophrenia risk variants
Author / Creator:Schrode, Nadine ; Ho, Seok-Man ; Yamamuro, Kazuhiko ; Dobbyn, Amanda ; Huckins, Laura ; Matos, Marliette R. ; Cheng, Esther ; Deans, P. J. Michael ; Flaherty, Erin ; Barretto, Natalie ; Topol, Aaron ; Alganem, Khaled ; Abadali, Sonya ; Gregory, James ; Hoelzli, Emily ; Phatnani, Hemali ; Singh, Vineeta ; Girish, Deeptha ; Aronow, Bruce ; Mccullumsmith, Robert ; Hoffman, Gabriel E. ; Stahl, Eli A. ; Morishita, Hirofumi ; Sklar, Pamela ; Brennand, Kristen J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2019-10, Vol.51 (10), p.1475-1485
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Modeling the complex genetic architectures of brain disease
Author / Creator:Fernando, Michael B. ; Ahfeldt, Tim ; Brennand, Kristen J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2020-04, Vol.52 (4), p.363-369
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Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
Author / Creator:Hoffman, Gabriel E. ; Hartley, Brigham J. ; Flaherty, Erin ; Ladran, Ian ; Gochman, Peter ; Ruderfer, Douglas M. ; Stahl, Eli A. ; Rapoport, Judith ; Sklar, Pamela ; Brennand, Kristen J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-12, Vol.8 (1), p.2225-15, Article 2225
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ArticlesPeer ReviewedFull Text
Mosaic Copy Number Variation in Human Neurons
Author / Creator:McConnell, Michael J. ; Lindberg, Michael R. ; Brennend, Kristen J. ; Piper, Julia C. ; Voet, Thierry ; Cowing-Zitron, Chris ; Shumilina, Svetlana ; Lasken, Roger S. ; Vermeesch, Joris R. ; Hall, Ira M. ; Gage, Fred H.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.632-637
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Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Author / Creator:Hashimoto-Torii, Kazue ; Torii, Masaaki ; Fujimoto, Mitsuaki ; Nakai, Akira ; El Fatimy, Rachid ; Mezger, Valerie ; Ju, Min J. ; Ishii, Seiji ; Chao, Shih-hui ; Brennand, Kristen J. ; Gage, Fred H. ; Rakic, Pasko
Publisher:United States: Elsevier Inc
Journal title:Neuron (Cambridge, Mass.), 2014-05, Vol.82 (3), p.560-572
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Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
Author / Creator:Wang, Minghui ; Roussos, Panos ; McKenzie, Andrew ; Zhou, Xianxiao ; Kajiwara, Yuji ; Brennand, Kristen J. ; De Luca, Gabriele C. ; Crary, John F. ; Casaccia, Patrizia ; Buxbaum, Joseph D. ; Ehrlich, Michelle ; Gandy, Sam ; Goate, Alison ; Katsel, Pavel ; Schadt, Eric ; Haroutunian, Vahram ; Zhang, Bin
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2016-11, Vol.8 (1), p.104-21, Article 104
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ArticlesPeer ReviewedFull Text
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Author / Creator:Jiang, Yan ; Loh, Yong-Hwee Eddie ; Rajarajan, Prashanth ; Hirayama, Teruyoshi ; Liao, Will ; Kassim, Bibi S ; Javidfar, Behnam ; Hartley, Brigham J ; Kleofas, Lisa ; Park, Royce B ; Labonte, Benoit ; Ho, Seok-Man ; Chandrasekaran, Sandhya ; Do, Catherine ; Ramirez, Brianna R ; Peter, Cyril J ; C W, Julia T ; Safaie, Brian M ; Morishita, Hirofumi ; Roussos, Panos ; Nestler, Eric J ; Schaefer, Anne ; Tycko, Benjamin ; Brennand, Kristen J ; Yagi, Takeshi ; Shen, Li ; Akbarian, Schahram
Publisher:New York: Springer New York
Journal title:Nature genetics, 2017-08, Vol.49 (8), p.1239-1250
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ArticlesPeer ReviewedFull Text
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
Author / Creator:Readhead, Benjamin ; Hartley, Brigham J ; Eastwood, Brian J ; Collier, David A ; Evans, David ; Farias, Richard ; He, Ching ; Hoffman, Gabriel ; Sklar, Pamela ; Dudley, Joel T ; Schadt, Eric E ; Savić, Radoslav ; Brennand, Kristen J
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-10, Vol.9, p.1-11
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Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Author / Creator:Farrelly, Lorna A. ; Zheng, Shuangping ; Schrode, Nadine ; Topol, Aaron ; Bhanu, Natarajan V. ; Bastle, Ryan M. ; Ramakrishnan, Aarthi ; Chan, Jennifer C ; Cetin, Bulent ; Flaherty, Erin ; Shen, Li ; Gleason, Kelly ; Tamminga, Carol A. ; Garcia, Benjamin A. ; Li, Haitao ; Brennand, Kristen J. ; Maze, Ian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-04, Vol.13 (1), p.2195-10, Article 2195
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ArticlesPeer ReviewedFull Text
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Author / Creator:Powell, Samuel K. ; O’Shea, Callan ; Townsley, Kayla ; Prytkova, Iya ; Dobrindt, Kristina ; Elahi, Rahat ; Iskhakova, Marina ; Lambert, Tova ; Valada, Aditi ; Liao, Will ; Ho, Seok-Man ; Slesinger, Paul A. ; Huckins, Laura M. ; Akbarian, Schahram ; Brennand, Kristen J.
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2023-05, Vol.28 (5), p.1970-1982
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Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
Author / Creator:Prytkova, Iya ; Brennand, Kristen J.
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2017-11, Vol.11, p.360
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GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis
Author / Creator:Kajiwara, Yuji ; Wang, Erming ; Wang, Minghui ; Sin, Wun Chey ; Brennand, Kristen J. ; Schadt, Eric ; Naus, Christian C. ; Buxbaum, Joseph ; Zhang, Bin
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2018-12, Vol.6 (1), p.144-20, Article 144
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Analysis framework and experimental design for evaluating synergy-driving gene expression
Author / Creator:Schrode, Nadine ; Seah, Carina ; Deans, P. J. Michael ; Hoffman, Gabriel ; Brennand, Kristen J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2021-02, Vol.16 (2), p.812-840
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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
Author / Creator:Fulton, Sasha L. ; Wenderski, Wendy ; Lepack, Ashley E. ; Eagle, Andrew L. ; Fanutza, Tomas ; Bastle, Ryan M. ; Ramakrishnan, Aarthi ; Hays, Emma C. ; Neal, Arianna ; Bendl, Jaroslav ; Farrelly, Lorna A. ; Al-Kachak, Amni ; Lyu, Yang ; Cetin, Bulent ; Chan, Jennifer C. ; Tran, Tina N. ; Neve, Rachael L. ; Roper, Randall J. ; Brennand, Kristen J. ; Roussos, Panos ; Schimenti, John C. ; Friedman, Allyson K. ; Shen, Li ; Blitzer, Robert D. ; Robison, Alfred J. ; Crabtree, Gerald R. ; Maze, Ian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-10, Vol.13 (1), p.6384-17, Article 6384
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Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Author / Creator:Hicks, Emily M ; Seah, Carina ; Cote, Alanna ; Marchese, Shelby ; Brennand, Kristen J ; Nestler, Eric J ; Girgenti, Matthew J ; Huckins, Laura M
Publisher:London: Nature Publishing Group
Journal title:Translational psychiatry, 2023-04, Vol.13 (1), p.129
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Modeling psychiatric disorders through reprogramming
Author / Creator:Brennand, Kristen J. ; Gage, Fred H.
Publisher:England: The Company of Biologists Ltd
Journal title:Disease models & mechanisms, 2012-01, Vol.5 (1), p.26-32
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ArticlesPeer ReviewedFull Text
Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
Author / Creator:Readhead, Benjamin ; Hartley, Brigham J ; Eastwood, Brian J ; Collier, David A ; Evans, David ; Farias, Richard ; He, Ching ; Hoffman, Gabriel ; Sklar, Pamela ; Dudley, Joel T ; Schadt, Eric E ; Savić, Radoslav ; Brennand, Kristen J
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-11, Vol.9, p.1-1
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ArticlesPeer ReviewedFull Text
New considerations for hiPSC-based models of neuropsychiatric disorders
Author / Creator:Hoffman, Gabriel E. ; Schrode, Nadine ; Flaherty, Erin ; Brennand, Kristen J.
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2019-01, Vol.24 (1), p.49-66
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Showing 1 to 20 of 85 results

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A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

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Synergistic effects of common schizophrenia risk variants

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Modeling the complex genetic architectures of brain disease

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Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

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Mosaic Copy Number Variation in Human Neurons

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Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

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Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

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The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain

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Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

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Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

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Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk

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Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells

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GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

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Analysis framework and experimental design for evaluating synergy-driving gene expression

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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

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Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

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Modeling psychiatric disorders through reprogramming

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Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

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New considerations for hiPSC-based models of neuropsychiatric disorders

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