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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics
Author / Creator:Rudrapal, Mithun ; Khan, Johra ; Dukhyil, Abdul Aziz Bin ; Alarousy, Randa Mohammed Ibrahim Ismail ; Attah, Emmanuel Ifeanyi ; Sharma, Tripti ; Khairnar, Shubham Jagdish ; Bendale, Atul Rupchand
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-11, Vol.26 (23), p.7177
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A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4′-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells
Author / Creator:Yang, Yan ; Wu, He ; Zou, Xiao ; Chen, Yongye ; He, Runjia ; Jin, Yibo ; Zhou, Bei ; Ge, Chunpo ; Yang, Yun
Publisher:Dordrecht: Springer Netherlands
Journal title:Cell stress & chaperones, 2022-11, Vol.27 (6), p.645-657
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Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2
Author / Creator:Ge, Xiangting ; Xu, Tingting ; Wang, Meiyan ; Gao, Lijiao ; Tang, Yue ; Zhang, Ningjie ; Zheng, Rui ; Zeng, Weimin ; Chen, Gaozhi ; Zhang, Bing ; Dai, Yuanrong ; Zhang, Yali
Publisher:England: BioMed Central Ltd
Journal title:European journal of medical research, 2024-01, Vol.29 (1), p.65-65, Article 65
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Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
Author / Creator:Padhye, Subhash ; Ahmad, Aamir ; Oswal, Nikhil ; Sarkar, Fazlul H
Publisher:England: BioMed Central Ltd
Journal title:Journal of hematology and oncology, 2009-09, Vol.2 (1), p.38-38, Article 38
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Anti-tumour activity of a novel coumarin–chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio
Author / Creator:Singh, Neetu ; Sarkar, Jayanta ; Sashidhara, Koneni V. ; Ali, Shakir ; Sinha, Sudhir
Publisher:Boston: Springer US
Journal title:Apoptosis (London), 2014-06, Vol.19 (6), p.1017-1028
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway
Author / Creator:Su, Qing ; Xu, Baolin ; Tian, Zhoubin ; Gong, Ziling
Publisher:Poland: Sciendo
Journal title:Acta Pharmaceutica, 2022-09, Vol.72 (3), p.389-402
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A Review of Experimental Studies on Natural Chalcone-Based Therapeutic Targeting of Genes and Signaling Pathways in Type 2 Diabetes Complications
Author / Creator:Alsharairi, Naser A
Publisher:Switzerland: MDPI AG
Journal title:Genes, 2024-07, Vol.15 (7), p.942
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Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS‐induced acute lung injury
Author / Creator:Zhang, Yali ; Xu, Tingting ; Wu, Beibei ; Chen, Hongjin ; Pan, Zheer ; Huang, Yi ; Mei, Liqin ; Dai, Yuanrong ; Liu, Xing ; Shan, Xiaoou ; Liang, Guang
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2017-04, Vol.21 (4), p.746-757
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Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis
Author / Creator:Ye, Jingxue ; Wang, Ruiying ; Wang, Min ; Fu, Jianhua ; Zhang, Qiong ; Sun, Guibo ; Sun, Xiaobo
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.6643615-6643615
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[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice
Author / Creator:WalyEldeen, Amr Ahmed ; El-Shorbagy, Haidan M. ; Hassaneen, Hamdi M. ; Abdelhamid, Ismail A. ; Sabet, Salwa ; Ibrahim, Sherif Abdelaziz
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Naunyn-Schmiedeberg's archives of pharmacology, 2022-10, Vol.395 (10), p.1225-1238
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Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway
Author / Creator:Zhou, Donglai ; Ding, Tingting ; Ni, Bin ; Jing, Yunyan ; Liu, Shanxin
Publisher:Athens: Spandidos Publications
Journal title:International journal of molecular medicine, 2019-08, Vol.44 (2), p.405-416
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Effects of Synthetic Ligustrazine-Based Chalcone Derivatives on Trypanosoma brucei brucei and Leishmania spp. Promastigotes
Author / Creator:Alkhaldi, Abdulsalam A M
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-06, Vol.28 (12), p.4652
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Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway
Author / Creator:Shi, Min ; Zeng, Xiaoxi ; Guo, Fan ; Huang, Rongshuang ; Feng, Yanhuan ; Ma, Liang ; Zhou, Li ; Fu, Ping
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-10, Vol.22 (10), p.1683
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HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury
Author / Creator:Pei, Jun-Peng ; Fan, Li-Hong ; Nan, Kai ; Li, Jia ; Dang, Xiao-Qian ; Wang, Kun-Zheng
Publisher:England: BioMed Central
Journal title:Journal of neuroinflammation, 2017-05, Vol.14 (1), p.97-97, Article 97
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Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat
Author / Creator:Deng, Yuxiu ; Li, Huilin ; Xie, Weidong ; Kou, Xinhui ; Chu, Shufang ; Li, Zengyin ; Chen, Jianping ; Liu, Deliang ; Liu, Xuemei ; Zhao, Hengxia ; Lee, Maosheng ; Liao, Si
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-11
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Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria
Author / Creator:Sinha, Shweta ; Medhi, Bikash ; Radotra, B D ; Batovska, Daniela I ; Markova, Nadezhda ; Bhalla, Ashish ; Sehgal, Rakesh
Publisher:England: BioMed Central Ltd
Journal title:BMC complementary and alternative medicine, 2022-12, Vol.22 (1), p.330-330, Article 330
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Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma
Author / Creator:Li, Zichao ; Zhang, Luying ; Gao, Mingquan ; Han, Mei ; Liu, Kaili ; Zhang, Zhuang ; Gong, Zhi ; Xing, Lifei ; Shi, Xianzhou ; Lu, Kui ; Gao, Hui
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2019-01, Vol.38 (1), p.8-8
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Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat
Author / Creator:Chen, Lin ; Xiang, Yanxiao ; Kong, Lingjun ; Zhang, Xiumei ; Sun, Baozhu ; Wei, Xinbing ; Liu, Huiqing
Publisher:Boston: Springer US
Journal title:Neurochemical research, 2013-11, Vol.38 (11), p.2268-2275
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Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway
Author / Creator:HU, TIANXIN ; WEI, GUO ; XI, MIAOMIAO ; YAN, JIAJIA ; WU, XIAOXIAO ; WANG, YANHUA ; ZHU, YANRONG ; WANG, CHAO ; WEN, AIDONG
Publisher:Athens: D.A. Spandidos
Journal title:International journal of molecular medicine, 2016-07, Vol.38 (1), p.83-94
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Suppression of LPS-Induced Inflammation by Chalcone Flavokawain A through Activation of Nrf2/ARE-Mediated Antioxidant Genes and Inhibition of ROS/NFκB Signaling Pathways in Primary Splenocytes
Author / Creator:Hseu, You Cheng ; Liao, Jiunn-Wang ; Liao, Chun-Huei ; Gowrisankar, Yugandhar Vudhya ; Yang, Ting-Yu ; Yang, Hsin-Ling ; Huang, Pei-Jane
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14
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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

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A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4′-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells

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Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2

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Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

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Anti-tumour activity of a novel coumarin–chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio

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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway

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A Review of Experimental Studies on Natural Chalcone-Based Therapeutic Targeting of Genes and Signaling Pathways in Type 2 Diabetes Complications

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Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS‐induced acute lung injury

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Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

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[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice

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Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway

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Effects of Synthetic Ligustrazine-Based Chalcone Derivatives on Trypanosoma brucei brucei and Leishmania spp. Promastigotes

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Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway

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HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury

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Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat

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Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria

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Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma

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Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat

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Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway

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Suppression of LPS-Induced Inflammation by Chalcone Flavokawain A through Activation of Nrf2/ARE-Mediated Antioxidant Genes and Inhibition of ROS/NFκB Signaling Pathways in Primary Splenocytes

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