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Design and Synthesis of ( Z )-2-(Benzylamino)-5-benzylidenethiazol-4(5 H )-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects
Author / Creator:Lee, Jieun ; Park, Yu Jung ; Jung, Hee Jin ; Ullah, Sultan ; Yoon, Dahye ; Jeong, Yeongmu ; Kim, Ga Young ; Kang, Min Kyung ; Kang, Dongwan ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.848
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Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Author / Creator:Choi, Yeon Ja ; Park, Yun Jung ; Park, Ji Young ; Jeong, Hyoung Oh ; Kim, Dae Hyun ; Ha, Young Mi ; Kim, Ji Min ; Song, Yu Min ; Heo, Hyoung-Sam ; Yu, Byung Pal ; Chun, Pusoon ; Moon, Hyung Ryong ; Chung, Hae Young
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-08, Vol.7 (8), p.e43418-e43418
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Design, Synthesis, and Anti-Tyrosinase, Anti-Melanogenic, and Antioxidant Activities of Novel (Z) -3-Benzyl-5-Benzylidene-2-Thioxothiazolidin-4-One Analogs
Author / Creator:Park, Hyeon Seo ; Jung, Hee Jin ; Park, Hye Soo ; Kim, Hye Jin ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (3), p.517
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Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of ( Z )-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5 H )-one Analogs: In Vitro and In Vivo Insights
Author / Creator:Jung, Hee Jin ; Kim, Hye Jin ; Park, Hyeon Seo ; Park, Hye Soo ; Ko, Jeongin ; Yoon, Dahye ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (2), p.289
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Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases
Author / Creator:Kim, Hye Jin ; Jung, Hee Jin ; Kim, Young Eun ; Jeong, Daeun ; Park, Hyeon Seo ; Park, Hye Soo ; Kang, Dongwan ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-06, Vol.29 (12), p.2887
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Exploration of Compounds with 2-Phenylbenzo[ d ]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity
Author / Creator:Jung, Hee Jin ; Park, Hyeon Seo ; Park, Hye Soo ; Kim, Hye Jin ; Yoon, Dahye ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-09, Vol.29 (17), p.4162
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A Potent Tyrosinase Inhibitor, ( E )-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells
Author / Creator:Kim, Chang Seok ; Noh, Sang Gyun ; Park, Yujin ; Kang, Dongwan ; Chun, Pusoon ; Chung, Hae Young ; Jung, Hee Jin ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2725
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Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5 H )-one Derivatives: A Novel Class of Anti-Melanogenic Compounds
Author / Creator:Yoon, Dahye ; Kang, Min Kyung ; Jung, Hee Jin ; Ullah, Sultan ; Lee, Jieun ; Jeong, Yeongmu ; Noh, Sang Gyun ; Kang, Dongwan ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-04, Vol.28 (8), p.3293
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PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling
Author / Creator:Kim, Min Jo ; Kim, Dae Hyun ; Bang, EunJin ; Noh, Sang Gyun ; Chun, Pusoon ; Yokozawa, Takako ; Moon, Hyung Ryong ; Chung, Hae Young
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-05, Vol.26 (11), p.3197
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ArticlesPeer ReviewedFull Text
Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment
Author / Creator:Ahn, Eun-Young ; Lee, You Jeong ; Park, Jisu ; Chun, Pusoon ; Park, Youmie
Publisher:New York: Springer US
Journal title:Nanoscale research letters, 2018-10, Vol.13 (1), p.348-14, Article 348
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( E )-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study
Author / Creator:Jung, Hee Jin ; Noh, Sang Gyun ; Ryu, Il Young ; Park, Chaeun ; Lee, Ji Young ; Chun, Pusoon ; Moon, Hyung Ryong ; Chung, Hae Young
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-11, Vol.25 (22), p.5460
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ArticlesPeer ReviewedFull Text
Novel Anti-Melanogenic Compounds, ( Z )-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights
Author / Creator:Choi, Heejeong ; Ryu, Il Young ; Choi, Inkyu ; Ullah, Sultan ; Jung, Hee Jin ; Park, Yujin ; Jeong, Yeongmu ; Hwang, YeJi ; Hong, Sojeong ; Yoon, In-Soo ; Yun, Hwayoung ; Kim, Min-Soo ; Yoo, Jin-Wook ; Jung, Yunjin ; Chun, Pusoon ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-08, Vol.26 (16), p.4963
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Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[ d ]imidazole Derivatives Serving as Tyrosinase Inhibitors: An In Silico, In Vitro, and In Vivo Exploration
Author / Creator:Jung, Hee Jin ; Park, Hyeon Seo ; Kim, Hye Jin ; Park, Hye Soo ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Antioxidants, 2024-10, Vol.13 (10), p.1248
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ArticlesPeer ReviewedFull Text
Anti-Browning Effect of 2-Mercaptobenzo[d]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity
Author / Creator:Lee, Jieun ; Park, Hye Soo ; Jung, Hee Jin ; Park, Yu Jung ; Kang, Min Kyung ; Kim, Hye Jin ; Yoon, Dahye ; Ullah, Sultan ; Kang, Dongwan ; Park, Yujin ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Basel: MDPI AG
Journal title:Antioxidants, 2023-09, Vol.12 (10), p.1814
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ArticlesPeer ReviewedFull Text
Identification of a Novel Class of Anti-Melanogenic Compounds, ( Z )-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities
Author / Creator:Jeong, Yeongmu ; Hong, Sojeong ; Jung, Hee Jin ; Ullah, Sultan ; Hwang, YeJi ; Choi, Heejeong ; Ko, Jeongin ; Lee, Jieun ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Switzerland: MDPI AG
Journal title:Antioxidants, 2022-05, Vol.11 (5), p.948
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A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights
Author / Creator:Hwang, YeJi ; Lee, Jieun ; Jung, Hee Jin ; Ullah, Sultan ; Ko, Jeongin ; Jeong, Yeongmu ; Park, Yu Jung ; Kang, Min Kyung ; Yun, Hwayoung ; Kim, Min-Soo ; Chun, Pusoon ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Basel: MDPI AG
Journal title:Antioxidants, 2022-07, Vol.11 (7), p.1375
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Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice
Author / Creator:Park, Min Hi ; Park, Ji Young ; Lee, Hye Jin ; Kim, Dae Hyun ; Park, Daeui ; Jeong, Hyoung Oh ; Park, Chan Hum ; Chun, Pusoon ; Moon, Hyung Ryong ; Chung, Hae Young
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-11, Vol.8 (11), p.e78815-e78815
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ArticlesPeer ReviewedFull Text
Design and Synthesis of (Z)-5-(Substituted benzylidene)-3-cyclohexyl-2-thioxothiazolidin-4-one Analogues as Anti-Tyrosinase and Antioxidant Compounds: In Vitro and In Silico Insights
Author / Creator:Ko, Jeongin ; Lee, Jieun ; Jung, Hee Jin ; Ullah, Sultan ; Jeong, Yeongmu ; Hong, Sojeong ; Kang, Min Kyung ; Park, Yu Jung ; Hwang, YeJi ; Kang, Dongwan ; Park, Yujin ; Chun, Pusoon ; Yoo, Jin-Wook ; Chung, Hae Young ; Moon, Hyung Ryong
Publisher:Basel: MDPI AG
Journal title:Antioxidants, 2022-09, Vol.11 (10), p.1918
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A novel anthracene derivative, MHY412, induces apoptosis in doxorubicin-resistant MCF-7/Adr human breast cancer cells through cell cycle arrest and downregulation of P-glycoprotein expression
Author / Creator:DE, UMASANKAR ; CHUN, PUSOON ; CHOI, WAHN SOO ; LEE, BYUNG MU ; KIM, NAM DEUK ; MOON, HYUNG RYONG ; JUNG, JEE H ; KIM, HYUNG SIK
Publisher:Athens: D.A. Spandidos
Journal title:International journal of oncology, 2014-01, Vol.44 (1), p.167-176
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The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity
Author / Creator:Park, Min Hi ; Park, Ji Young ; Lee, Hye Jin ; Kim, Dae Hyun ; Chung, Ki Wung ; Park, Daeui ; Jeong, Hyoung Oh ; Kim, Hye Rim ; Park, Chan Hum ; Kim, So Ra ; Chun, Pusoon ; Byun, Youngjoo ; Moon, Hyung Ryong ; Chung, Hae Young
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e76820
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Design and Synthesis of ( Z )-2-(Benzylamino)-5-benzylidenethiazol-4(5 H )-one Derivatives as Tyrosinase Inhibitors and Their Anti-Melanogenic and Antioxidant Effects

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Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion

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Design, Synthesis, and Anti-Tyrosinase, Anti-Melanogenic, and Antioxidant Activities of Novel (Z) -3-Benzyl-5-Benzylidene-2-Thioxothiazolidin-4-One Analogs

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Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of ( Z )-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5 H )-one Analogs: In Vitro and In Vivo Insights

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Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases

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Exploration of Compounds with 2-Phenylbenzo[ d ]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity

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A Potent Tyrosinase Inhibitor, ( E )-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

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Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5 H )-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

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PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling

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Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment

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( E )-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study

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Novel Anti-Melanogenic Compounds, ( Z )-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

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Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[ d ]imidazole Derivatives Serving as Tyrosinase Inhibitors: An In Silico, In Vitro, and In Vivo Exploration

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Anti-Browning Effect of 2-Mercaptobenzo[d]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity

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Identification of a Novel Class of Anti-Melanogenic Compounds, ( Z )-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities

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A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights

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Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice

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Design and Synthesis of (Z)-5-(Substituted benzylidene)-3-cyclohexyl-2-thioxothiazolidin-4-one Analogues as Anti-Tyrosinase and Antioxidant Compounds: In Vitro and In Silico Insights

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A novel anthracene derivative, MHY412, induces apoptosis in doxorubicin-resistant MCF-7/Adr human breast cancer cells through cell cycle arrest and downregulation of P-glycoprotein expression

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The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity

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