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27 results for Cognitive+Dysfunction+-+enzymology

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Author / Creator:Heneka, Michael T. ; Kummer, Markus P. ; Stutz, Andrea ; Delekate, Andrea ; Schwartz, Stephanie ; Vieira-Saecker, Ana ; Griep, Angelika ; Axt, Daisy ; Remus, Anita ; Tzeng, Te-Chen ; Gelpi, Ellen ; Halle, Annett ; Korte, Martin ; Latz, Eicke ; Golenbock, Douglas T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-01, Vol.493 (7434), p.674-678
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Clinical Implication of Phosphodiesterase-4-Inhibition
Author / Creator:Schick, Martin Alexander ; Schlegel, Nicolas
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-01, Vol.23 (3), p.1209
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PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease
Author / Creator:Nackenoff, Alex G. ; Hohman, Timothy J. ; Neuner, Sarah M. ; Akers, Carolyn S. ; Weitzel, Nicole C. ; Shostak, Alena ; Ferguson, Shawn M. ; Mobley, Bret ; Bennett, David A. ; Schneider, Julie A. ; Jefferson, Angela L. ; Kaczorowski, Catherine C. ; Schrag, Matthew S.
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2021-04, Vol.17 (4), p.e1009406
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Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK
Author / Creator:Shiers, Stephanie ; Mwirigi Juliet ; Pradhan Grishma ; Kume Moeno ; Black, Bryan ; Barragan-Iglesias Paulino ; Moy, Jamie K ; Dussor, Gregory ; Pancrazio, Joseph J ; Kroener Sven ; Price, Theodore J
Publisher:New York: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2020-02, Vol.45 (3), p.524-533
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ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment
Author / Creator:Vilarinho, Sílvia ; Sari, Sinan ; Mazzacuva, Francesca ; Bilgüvar, Kaya ; Esendagli-Yilmaz, Güldal ; Jain, Dhanpat ; Akyol, Gülen ; Dalgiç, Buket ; Günel, Murat ; Clayton, Peter T. ; Lifton, Richard P.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (40), p.11289-11293
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Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease
Author / Creator:Vezzoli, Elena ; Caron, Ilaria ; Talpo, Francesca ; Besusso, Dario ; Conforti, Paola ; Battaglia, Elisa ; Sogne, Elisa ; Falqui, Andrea ; Petricca, Lara ; Verani, Margherita ; Martufi, Paola ; Caricasole, Andrea ; Bresciani, Alberto ; Cecchetti, Ottavia ; Rivetti di Val Cervo, Pia ; Sancini, Giulio ; Riess, Olaf ; Nguyen, Hoa ; Seipold, Lisa ; Saftig, Paul ; Biella, Gerardo ; Cattaneo, Elena ; Zuccato, Chiara
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-06, Vol.129 (6), p.2390-2403
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Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
Author / Creator:Munkácsy, Erin ; Chocron, E. Sandra ; Quintanilla, Laura ; Gendron, Christi M. ; Pletcher, Scott D. ; Pickering, Andrew M.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2019-10, Vol.18 (5), p.e13005-n/a
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Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD
Author / Creator:Mei, Yingxue ; She, Fei ; Zhang, Ling ; Kim, Gamin ; Li, Ruomeng ; Zheng, Xiuzhi ; Wang, Zonghai ; Chen, Renxuan ; Wang, Long ; Chen, Dongmei ; Kim, Jungho ; Zhang, Tao ; Lee, Tae Ho
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2025-03, Vol.16 (1), p.151-18, Article 151
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Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats
Author / Creator:Chen, Xiaohui ; Chen, Dongtai ; Li, Qiang ; Wu, Shuyan ; Pan, Jiahao ; Liao, Yanling ; Zheng, Xiaochun ; Zeng, Weian
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.6643171
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A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer’s Disease and MCI Patients: Implications for Regenerative Medicine Approaches
Author / Creator:Morena, Francesco ; Argentati, Chiara ; Trotta, Rosa ; Crispoltoni, Lucia ; Stabile, Anna ; Pistilli, Alessandra ; Di Baldassarre, Angela ; Calafiore, Riccardo ; Montanucci, Pia ; Basta, Giuseppe ; Pedrinolla, Anna ; Smania, Nicola ; Venturelli, Massimo ; Schena, Federico ; Naro, Fabio ; Emiliani, Carla ; Rende, Mario ; Martino, Sabata
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2017-08, Vol.18 (8), p.1806
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ArticlesPeer ReviewedFull Text
HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction
Author / Creator:Sun, Xiao-Yu ; Zheng, Teng ; Yang, Xiu ; Liu, Le ; Gao, Shen-Shen ; Xu, Han-Bing ; Song, Yu-Tong ; Tong, Kun ; Yang, Li ; Gao, Ya ; Wu, Tong ; Hao, Jing-Ru ; Lu, Chen ; Ma, Tao ; Gao, Can
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2019-12, Vol.16 (1), p.249-17, Article 249
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ArticlesPeer ReviewedFull Text
The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats
Author / Creator:Nikaido, Yoshikazu ; Midorikawa, Yoko ; Furukawa, Tomonori ; Shimoyama, Shuji ; Takekawa, Daiki ; Kitayama, Masato ; Ueno, Shinya ; Kushikata, Tetsuya ; Hirota, Kazuyoshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-01, Vol.12 (1), p.249-10, Article 249
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Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease
Author / Creator:Mufson, Elliott J. ; He, Bin ; Nadeem, Muhammad ; Perez, Sylvia E. ; Counts, Scott E. ; Leurgans, Sue ; Fritz, Jason ; Lah, James ; Ginsberg, Stephen D. ; Wuu, Joanne ; Scheff, Stephen W.
Publisher:Hagerstown, MD: American Association of Neuropathologists, Inc
Journal title:Journal of neuropathology and experimental neurology, 2012-11, Vol.71 (11), p.1018-1029
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A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease
Author / Creator:Yeo, In Jun ; Lee, Min Jae ; Baek, Ahruem ; Miller, Zachary ; Bhattarai, Deepak ; Baek, Yu Mi ; Jeong, Hyun Jung ; Kim, Yun Kyung ; Kim, Dong-Eun ; Hong, Jin Tae ; Kim, Kyung Bo
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-12, Vol.9 (1), p.18393-13, Article 18393
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Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure
Author / Creator:Liao Zhaoxia ; Li, Junhua ; Miao Liping ; Huang Zeqi ; Huang Wujian ; Liu Yafang ; Li, Yujuan
Publisher:New York: Springer Nature B.V
Journal title:Neurochemical research, 2021-03, Vol.46 (3), p.468-481
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Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis
Author / Creator:Rahn, Kristen A ; Watkins, Crystal C ; Alt, Jesse ; Rais, Rana ; Stathis, Marigo ; Grishkan, Inna ; Crainiceau, Ciprian M ; Pomper, Martin G ; Rojas, Camilo ; Pletnikov, Mikhail V ; Calabresi, Peter A ; Brandt, Jason ; Barker, Peter B ; Slusher, Barbara S ; Kaplin, Adam I
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (49), p.20101-20106
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Synthetic β-hydroxy ketone derivative inhibits cholinesterases, rescues oxidative stress and ameliorates cognitive deficits in 5XFAD mice model of AD
Author / Creator:Ahmad Syed Ilyas ; Gowhar, Ali ; Tahir, Muhammad ; Ullah Rahim ; Umar, Muhammad Naveed ; Hashmi, Aisha Nasir
Publisher:Dordrecht: Springer Nature B.V
Journal title:Molecular biology reports, 2020-12, Vol.47 (12), p.9553-9566
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Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice
Author / Creator:Wagner, Lisa K. ; Gilling, Kate E. ; Schormann, Eileen ; Kloetzel, Peter M. ; Heppner, Frank L. ; Krüger, Elke ; Prokop, Stefan
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2017-06, Vol.5 (1), p.52-16, Article 52
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Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits
Author / Creator:Noël Anastasia ; Foveau Bénédicte ; LeBlanc, Andréa C
Publisher:London: Springer Nature B.V
Journal title:Cell death & disease, 2021-03, Vol.12 (3)
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Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats
Author / Creator:Zhang, Liying ; Zheng, Haiqing ; Luo, Jing ; Li, Lili ; Pan, Xiaona ; Jiang, Ting ; Xiao, Chongjun ; Pei, Zhong ; Hu, Xiquan
Publisher:England: Nature Publishing Group
Journal title:Hypertension research, 2018-06, Vol.41 (6), p.414-425
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Showing 1 to 20 of 27 results

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Clinical Implication of Phosphodiesterase-4-Inhibition

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PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

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Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

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ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment

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Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease

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Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

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Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD

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Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats

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A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer’s Disease and MCI Patients: Implications for Regenerative Medicine Approaches

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HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

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The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats

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Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

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A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease

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Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure

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Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

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Synthetic β-hydroxy ketone derivative inhibits cholinesterases, rescues oxidative stress and ameliorates cognitive deficits in 5XFAD mice model of AD

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Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

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Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

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Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats

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