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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
Author / Creator:Cynis, Holger ; Hoffmann, Torsten ; Friedrich, Daniel ; Kehlen, Astrid ; Gans, Kathrin ; Kleinschmidt, Martin ; Rahfeld, Jens‐Ulrich ; Wolf, Raik ; Wermann, Michael ; Stephan, Anett ; Haegele, Monique ; Sedlmeier, Reinhard ; Graubner, Sigrid ; Jagla, Wolfgang ; Müller, Anke ; Eichentopf, Rico ; Heiser, Ulrich ; Seifert, Franziska ; Quax, Paul H. A. ; de Vries, Margreet R. ; Hesse, Isabel ; Trautwein, Daniela ; Wollert, Ulrich ; Berg, Sabine ; Freyse, Ernst‐Joachim ; Schilling, Stephan ; Demuth, Hans‐Ulrich
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2011-09, Vol.3 (9), p.545-558
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Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme
Author / Creator:Gnoth, Kathrin ; Bär, Joachim Wolfgang ; Rosche, Fred ; Rahfeld, Jens-Ulrich ; Demuth, Hans-Ulrich
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-04, Vol.19 (4), p.e0289239-e0289239
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Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
Author / Creator:Köppen, Janett ; Schulze, Anja ; Machner, Lisa ; Wermann, Michael ; Eichentopf, Rico ; Guthardt, Max ; Hähnel, Angelika ; Klehm, Jessica ; Kriegeskorte, Marie-Christin ; Hartlage-Rübsamen, Maike ; Morawski, Markus ; von Hörsten, Stephan ; Demuth, Hans-Ulrich ; Roßner, Steffen ; Schilling, Stephan
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-01, Vol.25 (3), p.580
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Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors
Author / Creator:Hielscher-Michael, Stephanie ; Griehl, Carola ; Buchholz, Mirko ; Demuth, Hans-Ulrich ; Arnold, Norbert ; Wessjohann, Ludger A
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2016-11, Vol.14 (11), p.203-203
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QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
Author / Creator:Yates, Sharon C ; Groeneboom, Nicolaas E ; Coello, Christopher ; Lichtenthaler, Stefan F ; Kuhn, Peer-Hendrik ; Demuth, Hans-Ulrich ; Hartlage-Rübsamen, Maike ; Roßner, Steffen ; Leergaard, Trygve ; Kreshuk, Anna ; Puchades, Maja A ; Bjaalie, Jan G
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroinformatics, 2019-12, Vol.13, p.75-75
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Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
Author / Creator:Dammers, Christina ; Gremer, Lothar ; Neudecker, Philipp ; Demuth, Hans-Ulrich ; Schwarten, Melanie ; Willbold, Dieter
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-10, Vol.10 (10), p.e0139710
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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
Author / Creator:Parthier, Christoph ; Kleinschmidt, Martin ; Neumann, Piotr ; Rudolph, Rainer ; Manhart, Susanne ; Schlenzig, Dagmar ; Fanghänel, Jörg ; Rahfeld, Jens-Ulrich ; Demuth, Hans-Ulrich ; Stubbs, Milton T
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (35), p.13942-13947
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Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol
Author / Creator:Dammers, Christina ; Gremer, Lothar ; Reiß, Kerstin ; Klein, Antonia N ; Neudecker, Philipp ; Hartmann, Rudolf ; Sun, Na ; Demuth, Hans-Ulrich ; Schwarten, Melanie ; Willbold, Dieter
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-11, Vol.10 (11), p.e0143647-e0143647
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A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Author / Creator:Barendrecht, Susan ; Schreurs, An ; Geissler, Stefanie ; Sabanov, Victor ; Ilse, Victoria ; Rieckmann, Vera ; Eichentopf, Rico ; Künemund, Anja ; Hietel, Benjamin ; Wussow, Sebastian ; Hoffmann, Katrin ; Körber-Ferl, Kerstin ; Pandey, Ravi ; Carter, Gregory W ; Demuth, Hans-Ulrich ; Holzer, Max ; Roßner, Steffen ; Schilling, Stephan ; Preuss, Christoph ; Balschun, Detlef ; Cynis, Holger
Publisher:England: BioMed Central Ltd
Journal title:Alzheimer's research & therapy, 2023-01, Vol.15 (1), p.16-23, Article 16
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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
Author / Creator:Hartlage-Rübsamen, Maike ; Bluhm, Alexandra ; Piechotta, Anke ; Linnert, Miriam ; Rahfeld, Jens-Ulrich ; Demuth, Hans-Ulrich ; Lues, Inge ; Kuhn, Peer-Hendrik ; Lichtenthaler, Stefan F ; Roßner, Steffen ; Höfling, Corinna
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-04, Vol.23 (4), p.924
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Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology
Author / Creator:Gnoth, Kathrin ; Piechotta, Anke ; Kleinschmidt, Martin ; Konrath, Sandra ; Schenk, Mathias ; Taudte, Nadine ; Ramsbeck, Daniel ; Rieckmann, Vera ; Geissler, Stefanie ; Eichentopf, Rico ; Barendrecht, Susan ; Hartlage-Rübsamen, Maike ; Demuth, Hans-Ulrich ; Roßner, Steffen ; Cynis, Holger ; Rahfeld, Jens-Ulrich ; Schilling, Stephan
Publisher:England: BioMed Central
Journal title:Alzheimer's research & therapy, 2020-11, Vol.12 (1), p.149-149, Article 149
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ArticlesPeer ReviewedFull Text
The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals Its Functional Regulation and Enzymatic Mechanism
Author / Creator:Engel, Michael ; Hoffmann, Torsten ; Wagner, Leona ; Wermann, Michael ; Heiser, Ulrich ; Kiefersauer, Reiner ; Huber, Robert ; Bode, Wolfram ; Demuth, Hans-Ulrich ; Brandstetter, Hans
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (9), p.5063-5068
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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
Author / Creator:POSPISILIK, J. Andrew ; MARTIN, Jennifer ; DOTY, Timothy ; EHSES, Jan A ; PAMIR, Nathalie ; LYNN, Francis C ; PITEAU, Shalea ; DEMUTH, Hans-Ulrich ; MCINTOSH, Christopher H. S ; PEDERSON, Raymond A
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2003-03, Vol.52 (3), p.741-750
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ArticlesPeer ReviewedFull Text
Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease
Author / Creator:Hartlage-Rübsamen, Maike ; Ratz, Veronika ; Zeitschel, Ulrike ; Finzel, Lukas ; Machner, Lisa ; Köppen, Janett ; Schulze, Anja ; Demuth, Hans-Ulrich ; von Hörsten, Stephan ; Höfling, Corinna ; Roßner, Steffen
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2019-05, Vol.7 (1), p.79-19, Article 79
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Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
Author / Creator:PEDERSON, R. A ; WHITE, H. A ; SCHLENZIG, D ; PAULY, R. P ; MCINTOSH, C. H. S ; DEMUTH, H.-U
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 1998-08, Vol.47 (8), p.1253-1258
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Dipeptidyl Peptidase IV-Resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats
Author / Creator:HINKE, Simon A ; GELLING, Richard W ; PEDERSON, Raymond A ; MANHART, Susanne ; CUILAN NIAN ; DEMUTH, Hans-Ulrich ; MCINTOSH, Christopher H. S
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2002-03, Vol.51 (3), p.652-661
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Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway
Author / Creator:Schulz, Ingo ; Engel, Claudia ; Niestroj, André J ; Zeitschel, Ulrike ; Menge, Katja ; Kehlen, Astrid ; Meyer, Antje ; Rossner, Steffen ; Demuth, Hans-Ulrich
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2011-07, Vol.8 (1), p.86-86, Article 86
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Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model
Author / Creator:Tanghe, An ; Termont, Annelies ; Merchiers, Pascal ; Schilling, Stephan ; Demuth, Hans-Ulrich ; Scrocchi, Louise ; Van Leuven, Fred ; Griffioen, Gerard ; Van Dooren, Tom
Publisher:Cairo, Egypt: Hindawi Puplishing Corporation
Journal title:International journal of alzheimer's disease, 2010-09, Vol.2010 (2010), p.1-9
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Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Author / Creator:Nussbaum, Justin M. ; Schilling, Stephan ; Cynis, Holger ; Silva, Antonia ; Swanson, Eric ; Wangsanut, Tanaporn ; Tayler, Kaycie ; Wiltgen, Brian ; Hatami, Asa ; Rönicke, Raik ; Reymann, Klaus ; Hutter-Paier, Birgit ; Alexandru, Anca ; Jagla, Wolfgang ; Graubner, Sigrid ; Glabe, Charles G. ; Demuth, Hans-Ulrich ; Bloom, George S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-05, Vol.485 (7400), p.651-655
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Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
Author / Creator:Wirths, Oliver ; Breyhan, Henning ; Cynis, Holger ; Schilling, Stephan ; Demuth, Hans-Ulrich ; Bayer, Thomas A.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Acta neuropathologica, 2009-10, Vol.118 (4), p.487-496
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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

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Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme

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Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

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Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors

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QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain

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Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

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Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

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A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation

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Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology

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The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals Its Functional Regulation and Enzymatic Mechanism

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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

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Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease

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Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

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Dipeptidyl Peptidase IV-Resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats

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Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

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Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

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Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

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Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

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