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ArticlesPeer ReviewedFull Text
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Author / Creator:Holth, Jerrah K. ; Fritschi, Sarah K. ; Wang, Chanung ; Pedersen, Nigel P. ; Cirrito, John R. ; Mahan, Thomas E. ; Finn, Mary Beth ; Manis, Melissa ; Geerling, Joel C. ; Fuller, Patrick M. ; Lucey, Brendan P. ; Holtzman, David M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2019-02, Vol.363 (6429), p.880-884
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Extracellular fluid viscosity enhances cell migration and cancer dissemination
Author / Creator:Bera, Kaustav ; Kiepas, Alexander ; Godet, Inês ; Li, Yizeng ; Mehta, Pranav ; Ifemembi, Brent ; Paul, Colin D. ; Sen, Anindya ; Serra, Selma A. ; Stoletov, Konstantin ; Tao, Jiaxiang ; Shatkin, Gabriel ; Lee, Se Jong ; Zhang, Yuqi ; Boen, Adrianna ; Mistriotis, Panagiotis ; Gilkes, Daniele M. ; Lewis, John D. ; Fan, Chen-Ming ; Feinberg, Andrew P. ; Valverde, Miguel A. ; Sun, Sean X. ; Konstantopoulos, Konstantinos
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-11, Vol.611 (7935), p.365-373
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Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Author / Creator:Da Mesquita, Sandro ; Louveau, Antoine ; Vaccari, Andrea ; Smirnov, Igor ; Cornelison, R. Chase ; Kingsmore, Kathryn M. ; Contarino, Christian ; Onengut-Gumuscu, Suna ; Farber, Emily ; Raper, Daniel ; Viar, Kenneth E. ; Powell, Romie D. ; Baker, Wendy ; Dabhi, Nisha ; Bai, Robin ; Cao, Rui ; Hu, Song ; Rich, Stephen S. ; Munson, Jennifer M. ; Lopes, M. Beatriz ; Overall, Christopher C. ; Acton, Scott T. ; Kipnis, Jonathan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-08, Vol.560 (7717), p.185-191
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Clearance systems in the brain—implications for Alzheimer disease
Author / Creator:Tarasoff-Conway, Jenna M. ; Carare, Roxana O. ; Osorio, Ricardo S. ; Glodzik, Lidia ; Butler, Tracy ; Fieremans, Els ; Axel, Leon ; Rusinek, Henry ; Nicholson, Charles ; Zlokovic, Berislav V. ; Frangione, Blas ; Blennow, Kaj ; Ménard, Joël ; Zetterberg, Henrik ; Wisniewski, Thomas ; de Leon, Mony J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Neurology, 2015-08, Vol.11 (8), p.457-470
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Author / Creator:Mestre, Humberto ; Hablitz, Lauren M ; Xavier, Anna Lr ; Feng, Weixi ; Zou, Wenyan ; Pu, Tinglin ; Monai, Hiromu ; Murlidharan, Giridhar ; Castellanos Rivera, Ruth M ; Simon, Matthew J ; Pike, Martin M ; Plá, Virginia ; Du, Ting ; Kress, Benjamin T ; Wang, Xiaowen ; Plog, Benjamin A ; Thrane, Alexander S ; Lundgaard, Iben ; Abe, Yoichiro ; Yasui, Masato ; Thomas, John H ; Xiao, Ming ; Hirase, Hajime ; Asokan, Aravind ; Iliff, Jeffrey J ; Nedergaard, Maiken
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2018-12, Vol.7
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Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain
Author / Creator:Ma, Qiaoli ; Ries, Miriam ; Decker, Yann ; Müller, Andreas ; Riner, Chantal ; Bücker, Arno ; Fassbender, Klaus ; Detmar, Michael ; Proulx, Steven T.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2019-01, Vol.137 (1), p.151-165
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Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
Author / Creator:Holter, Karl Erik ; Kehlet, Benjamin ; Devor, Anna ; Sejnowski, Terrence J. ; Dale, Anders M. ; Omholt, Stig W. ; Ottersen, Ole Petter ; Nagelhus, Erlend Arnulf ; Mardal, Kent-André ; Pettersen, Klas H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (37), p.9894-9899
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ArticlesPeer ReviewedFull Text
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Author / Creator:Iliff, Jeffrey J ; Lee, Hedok ; Yu, Mei ; Feng, Tian ; Logan, Jean ; Nedergaard, Maiken ; Benveniste, Helene
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-03, Vol.123 (3), p.1299-1309
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Vascular, glial, and lymphatic immune gateways of the central nervous system
Author / Creator:Engelhardt, Britta ; Carare, Roxana O. ; Bechmann, Ingo ; Flügel, Alexander ; Laman, Jon D. ; Weller, Roy O.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-09, Vol.132 (3), p.317-338
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Molecular mechanisms of brain water transport
Author / Creator:MacAulay, Nanna
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Neuroscience, 2021-06, Vol.22 (6), p.326-344
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ArticlesPeer ReviewedFull Text
Extracellular acidity and increased exosome release as key phenotypes of malignant tumors
Author / Creator:Logozzi, Mariantonia ; Spugnini, Enrico ; Mizzoni, Davide ; Di Raimo, Rossella ; Fais, Stefano
Publisher:New York: Springer US
Journal title:Cancer and metastasis reviews, 2019-06, Vol.38 (1-2), p.93-101
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Implications of the discovery of brain lymphatic pathways
Author / Creator:Iliff, Jeffrey J ; Goldman, Steven A ; Nedergaard, Maiken
Publisher:England: Elsevier Ltd
Journal title:Lancet neurology, 2015-10, Vol.14 (10), p.977-979
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ArticlesPeer ReviewedFull Text
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
Author / Creator:Murdock, Mitchell H. ; Yang, Cheng-Yi ; Sun, Na ; Pao, Ping-Chieh ; Blanco-Duque, Cristina ; Kahn, Martin C. ; Kim, TaeHyun ; Lavoie, Nicolas S. ; Victor, Matheus B. ; Islam, Md Rezaul ; Galiana, Fabiola ; Leary, Noelle ; Wang, Sidney ; Bubnys, Adele ; Ma, Emily ; Akay, Leyla A. ; Sneve, Madison ; Qian, Yong ; Lai, Cuixin ; McCarthy, Michelle M. ; Kopell, Nancy ; Kellis, Manolis ; Piatkevich, Kiryl D. ; Boyden, Edward S. ; Tsai, Li-Huei
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2024-03, Vol.627 (8002), p.149-156
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ArticlesPeer ReviewedFull Text
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Author / Creator:Gomolka, Ryszard Stefan ; Hablitz, Lauren M ; Mestre, Humberto ; Giannetto, Michael ; Du, Ting ; Hauglund, Natalie Linea ; Xie, Lulu ; Peng, Weiguo ; Martinez, Paula Melero ; Nedergaard, Maiken ; Mori, Yuki
Publisher:England: eLife Sciences Publications, Ltd
Journal title:eLife, 2023-02, Vol.12
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ArticlesPeer ReviewedFull Text
Cystathionine‐gamma‐lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy
Author / Creator:Lancien, Melanie ; Gueno, Lucile ; Salle, Sonia ; Merieau, Emmanuel ; Beriou, Gaelle ; Nguyen, Tuan H. ; Abidi, Ahmed ; Dilek, Nahzli ; Solomon, Pierre ; Poschmann, Jeremie ; Michielin, Olivier ; Vuillefroy de Silly, Romain ; Vanhove, Bernard ; Louvet, Cedric
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-05, Vol.112 (5), p.1723-1734
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ArticlesPeer ReviewedFull Text
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Author / Creator:CRAMER, Paige E ; CIRRITO, John R ; BRUNDEN, Kurt R ; WILSON, Donald A ; LANDRETH, Gary E ; WESSON, Daniel W ; DANIEL LEE, C. Y ; COLLEEN KARLO, J ; ZINN, Adriana E ; CASALI, Brad T ; RESTIVO, Jessica L ; GOEBET, Whitney D ; JAMES, Michael J
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-03, Vol.335 (6075), p.1503-1506
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Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
Author / Creator:Bischof, Helmut ; Rehberg, Markus ; Stryeck, Sarah ; Artinger, Katharina ; Eroglu, Emrah ; Waldeck-Weiermair, Markus ; Gottschalk, Benjamin ; Rost, Rene ; Deak, Andras T. ; Niedrist, Tobias ; Vujic, Nemanja ; Lindermuth, Hanna ; Prassl, Ruth ; Pelzmann, Brigitte ; Groschner, Klaus ; Kratky, Dagmar ; Eller, Kathrin ; Rosenkranz, Alexander R. ; Madl, Tobias ; Plesnila, Nikolaus ; Graier, Wolfgang F. ; Malli, Roland
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1422-12, Article 1422
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Arterial pulsations drive oscillatory flow of CSF but not directional pumping
Author / Creator:Kedarasetti, Ravi Teja ; Drew, Patrick J. ; Costanzo, Francesco
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-06, Vol.10 (1), p.10102-10102, Article 10102
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ArticlesPeer ReviewedFull Text
Fluid shear stress activates YAP1 to promote cancer cell motility
Author / Creator:Lee, Hyun Jung ; Diaz, Miguel F. ; Price, Katherine M. ; Ozuna, Joyce A. ; Zhang, Songlin ; Sevick-Muraca, Eva M. ; Hagan, John P. ; Wenzel, Pamela L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-01, Vol.8 (1), p.14122-14122, Article 14122
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Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
Author / Creator:Jiang-Xie, Li-Feng ; Drieu, Antoine ; Bhasiin, Kesshni ; Quintero, Daniel ; Smirnov, Igor ; Kipnis, Jonathan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2024-03, Vol.627 (8002), p.157-164
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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

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Extracellular fluid viscosity enhances cell migration and cancer dissemination

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Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

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Clearance systems in the brain—implications for Alzheimer disease

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Aquaporin-4-dependent glymphatic solute transport in the rodent brain

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Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

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Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

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Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

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Vascular, glial, and lymphatic immune gateways of the central nervous system

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Molecular mechanisms of brain water transport

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Extracellular acidity and increased exosome release as key phenotypes of malignant tumors

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Implications of the discovery of brain lymphatic pathways

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Multisensory gamma stimulation promotes glymphatic clearance of amyloid

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Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

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Cystathionine‐gamma‐lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy

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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

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Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

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Arterial pulsations drive oscillatory flow of CSF but not directional pumping

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Fluid shear stress activates YAP1 to promote cancer cell motility

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Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

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