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Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1
Author / Creator:Nosol, Kamil ; Romane, Ksenija ; Irobalieva, Rossitza N. ; Alam, Amer ; Kowal, Julia ; Fujita, Naoya ; Locher, Kaspar P.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (42), p.26245-26253
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Platelet-activating factor podoplanin: from discovery to drug development
Author / Creator:Takemoto, Ai ; Miyata, Kenichi ; Fujita, Naoya
Publisher:New York: Springer US
Journal title:Cancer and metastasis reviews, 2017-06, Vol.36 (2), p.225-234
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Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer
Author / Creator:Uchibori, Ken ; Inase, Naohiko ; Araki, Mitsugu ; Kamada, Mayumi ; Sato, Shigeo ; Okuno, Yasushi ; Fujita, Naoya ; Katayama, Ryohei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-03, Vol.8 (1), p.14768-14768, Article 14768
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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
Author / Creator:Mizuta, Hayato ; Okada, Koutaroh ; Araki, Mitsugu ; Adachi, Jun ; Takemoto, Ai ; Kutkowska, Justyna ; Maruyama, Kohei ; Yanagitani, Noriko ; Oh-hara, Tomoko ; Watanabe, Kana ; Tamai, Keiichi ; Friboulet, Luc ; Katayama, Kazuhiro ; Ma, Biao ; Sasakura, Yoko ; Sagae, Yukari ; Kukimoto-Niino, Mutsuko ; Shirouzu, Mikako ; Takagi, Satoshi ; Simizu, Siro ; Nishio, Makoto ; Okuno, Yasushi ; Fujita, Naoya ; Katayama, Ryohei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1261-1261, Article 1261
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Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis
Author / Creator:Takagi, Satoshi ; Sasaki, Yuki ; Koike, Sumie ; Takemoto, Ai ; Seto, Yosuke ; Haraguchi, Mizuki ; Ukaji, Takao ; Kawaguchi, Tokuichi ; Sugawara, Minoru ; Saito, Masanori ; Funauchi, Yuki ; Ae, Keisuke ; Matsumoto, Seiichi ; Fujita, Naoya ; Katayama, Ryohei
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2021-09, Vol.40 (36), p.5548-5558
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Drug resistance mechanisms in Japanese anaplastic lymphoma kinase‐positive non–small cell lung cancer and the clinical responses based on the resistant mechanisms
Author / Creator:Yanagitani, Noriko ; Uchibori, Ken ; Koike, Sumie ; Tsukahara, Mika ; Kitazono, Satoru ; Yoshizawa, Takahiro ; Horiike, Atsushi ; Ohyanagi, Fumiyoshi ; Tambo, Yuichi ; Nishikawa, Shingo ; Fujita, Naoya ; Katayama, Ryohei ; Nishio, Makoto
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2020-03, Vol.111 (3), p.932-939
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Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2
Author / Creator:Takagi, Satoshi ; Sato, Shigeo ; Oh-hara, Tomoko ; Takami, Miho ; Koike, Sumie ; Mishima, Yuji ; Hatake, Kiyohiko ; Fujita, Naoya
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-08, Vol.8 (8), p.e73609-e73609
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Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses
Author / Creator:Fujita, Naoya ; Mizuarai, Shinji ; Murakami, Katsuhiko ; Nakai, Kenta
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-06, Vol.8 (1), p.9743-10, Article 9743
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Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
Author / Creator:Hu, Dong ; Gur, Mert ; Zhou, Zhuan ; Gamper, Armin ; Hung, Mien-Chie ; Fujita, Naoya ; Lan, Li ; Bahar, Ivet ; Wan, Yong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-09, Vol.6 (1), p.8419, Article 8419
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Platelets promote osteosarcoma cell growth through activation of the platelet‐derived growth factor receptor‐Akt signaling axis
Author / Creator:Takagi, Satoshi ; Takemoto, Ai ; Takami, Miho ; Oh‐hara, Tomoko ; Fujita, Naoya
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2014-08, Vol.105 (8), p.983-988
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The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Author / Creator:Katayama, Ryohei ; Gong, Bo ; Togashi, Noriko ; Miyamoto, Masaya ; Kiga, Masaki ; Iwasaki, Shiho ; Kamai, Yasuki ; Tominaga, Yuichi ; Takeda, Yasuyuki ; Kagoshima, Yoshiko ; Shimizu, Yuki ; Seto, Yosuke ; Oh-hara, Tomoko ; Koike, Sumie ; Nakao, Naoki ; Hanzawa, Hiroyuki ; Watanabe, Kengo ; Yoda, Satoshi ; Yanagitani, Noriko ; Hata, Aaron N. ; Shaw, Alice T. ; Nishio, Makoto ; Fujita, Naoya ; Isoyama, Takeshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3604-12, Article 3604
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The long-acting C5 inhibitor, ravulizumab, is efficacious and safe in pediatric patients with atypical hemolytic uremic syndrome previously treated with eculizumab
Author / Creator:Tanaka, Kazuki ; Adams, Brigitte ; Aris, Alvaro Madrid ; Fujita, Naoya ; Ogawa, Masayo ; Ortiz, Stephan ; Vallee, Marc ; Greenbaum, Larry A.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Pediatric nephrology (Berlin, West), 2021-04, Vol.36 (4), p.889-898
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Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
Author / Creator:Miyata, Kenichi ; Takemoto, Ai ; Okumura, Sakae ; Nishio, Makoto ; Fujita, Naoya
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-06, Vol.7 (1), p.4059-12, Article 4059
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Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease
Author / Creator:Uemura, Osamu ; Nagai, Takuhito ; Ishikura, Kenji ; Ito, Shuichi ; Hataya, Hiroshi ; Gotoh, Yoshimitsu ; Fujita, Naoya ; Akioka, Yuko ; Kaneko, Tetsuji ; Honda, Masataka
Publisher:Tokyo: Springer Japan
Journal title:Clinical and experimental nephrology, 2014-08, Vol.18 (4), p.626-633
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Validation of the estimated glomerular filtration rate equation for Japanese children younger than 2 years
Author / Creator:Gotoh, Yoshimitsu ; Uemura, Osamu ; Fujita, Naoya ; Hamasaki, Yuko ; Honda, Masataka ; Ishikura, Kenji
Publisher:Singapore: Springer Singapore
Journal title:Clinical and experimental nephrology, 2022-03, Vol.26 (3), p.266-271
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Novel knock‐in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin–targeting agents
Author / Creator:Ukaji, Takao ; Takemoto, Ai ; Shibata, Harumi ; Kakino, Mamoru ; Takagi, Satoshi ; Katayama, Ryohei ; Fujita, Naoya
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-06, Vol.112 (6), p.2299-2313
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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal
Author / Creator:Tsuruo, Takashi ; Naito, Mikihiko ; Tomida, Akihiro ; Fujita, Naoya ; Mashima, Tetsuo ; Sakamoto, Hiroshi ; Haga, Naomi
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:Cancer science, 2003-01, Vol.94 (1), p.15-21
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Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer
Author / Creator:Sakashita, Takuya ; Yanagitani, Noriko ; Koike, Sumie ; Low, Siew‐Kee ; Takagi, Satoshi ; Baba, Satoko ; Takeuchi, Kengo ; Nishio, Makoto ; Fujita, Naoya ; Katayama, Ryohei
Publisher:Tokyo: John Wiley & Sons, Inc
Journal title:Cancer science, 2022-11, Vol.113 (11), p.3888-3900
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Modulation of Akt Kinase Activity by Binding to Hsp90
Author / Creator:Sato, Saori ; Fujita, Naoya ; Tsuruo, Takashi
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (20), p.10832-10837
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Ultrasonographic reference values and a simple yet practical formula for estimating average kidney length in Japanese children
Author / Creator:Fujita, Naoya ; Uemura, Osamu ; Harada, Ryoko ; Matsumura, Chieko ; Sakai, Tomoyuki ; Hamasaki, Yuko ; Kamei, Koichi ; Nishi, Kentaro ; Kaneko, Tetsuji ; Ishikura, Kenji ; Gotoh, Yoshimitsu
Publisher:Singapore: Springer Nature Singapore
Journal title:Clinical and experimental nephrology, 2022-08, Vol.26 (8), p.808-818
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Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

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Platelet-activating factor podoplanin: from discovery to drug development

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Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer

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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

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Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

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Drug resistance mechanisms in Japanese anaplastic lymphoma kinase‐positive non–small cell lung cancer and the clinical responses based on the resistant mechanisms

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Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2

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Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses

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Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

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Platelets promote osteosarcoma cell growth through activation of the platelet‐derived growth factor receptor‐Akt signaling axis

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The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models

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The long-acting C5 inhibitor, ravulizumab, is efficacious and safe in pediatric patients with atypical hemolytic uremic syndrome previously treated with eculizumab

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Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation

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Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease

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Validation of the estimated glomerular filtration rate equation for Japanese children younger than 2 years

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Novel knock‐in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin–targeting agents

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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

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Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer

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Modulation of Akt Kinase Activity by Binding to Hsp90

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Ultrasonographic reference values and a simple yet practical formula for estimating average kidney length in Japanese children

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