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Therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment
Author / Creator:Sharma, Alok ; Paliwal, Geetanjali ; Upadhyay, Nisha ; Tiwari, Archana
Publisher:Switzerland: BioMed Central Ltd
Journal title:Journal of diabetes and metabolic disorders, 2015-03, Vol.14, p.15-15
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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial
Author / Creator:Rosenstock, Julio ; Wysham, Carol ; Frías, Juan P ; Kaneko, Shizuka ; Lee, Clare J ; Fernández Landó, Laura ; Mao, Huzhang ; Cui, Xuewei ; Karanikas, Chrisanthi A ; Thieu, Vivian T
Publisher:London: Elsevier Ltd
Journal title:The Lancet (British edition), 2021-07, Vol.398 (10295), p.143-155
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Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Author / Creator:Jastreboff, Ania M. ; Kaplan, Lee M. ; Frías, Juan P. ; Wu, Qiwei ; Du, Yu ; Gurbuz, Sirel ; Coskun, Tamer ; Haupt, Axel ; Milicevic, Zvonko ; Hartman, Mark L.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-08, Vol.389 (6), p.514-526
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Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-grou...
Author / Creator:Ludvik, Bernhard ; Giorgino, Francesco ; Jódar, Esteban ; Frias, Juan P ; Fernández Landó, Laura ; Brown, Katelyn ; Bray, Ross ; Rodríguez, Ángel
Publisher:London: Elsevier Ltd
Journal title:The Lancet (British edition), 2021-08, Vol.398 (10300), p.583-598
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Retraction Note: therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment
Author / Creator:Sharma, Alok ; Paliwal, Geetanjali ; Upadhyay, Nisha ; Tiwari, Archana
Publisher:London: BioMed Central
Journal title:Journal of diabetes and metabolic disorders, 2016-08, Vol.15 (1), p.34-34, Article 34
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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
Author / Creator:Garvey, W Timothy ; Frias, Juan P ; Jastreboff, Ania M ; le Roux, Carel W ; Sattar, Naveed ; Aizenberg, Diego ; Mao, Huzhang ; Zhang, Shuyu ; Ahmad, Nadia N ; Bunck, Mathijs C ; Benabbad, Imane ; Zhang, Xiaotian M ; Abalos, Franklin H. ; Manghi, Federico C.P. ; Zaidman, Cesar J. ; Vico, Marisa L. ; Aizenberg, Diego ; Costanzo, Pablo R. ; Serra, Leonardo P. ; MacKinnon, Ignacio J. ; Hissa, Miguel N. ; Vidotti, Maria H. ; Kerr Saraiva, Jose F. ; Alves, Breno B. ; Franco, Denise R. ; Moratto, Otavio ; Murthy, Sreenivasa ; Goyal, Ghanshyam ; Yamasaki, Yoshimitsu ; Sato, Nobuyuki ; Inoue, Satoshi ; Asakura, Taro ; Shestakova, Marina ; Khaykina, Elena ; Troshina, Ekaterina ; Vorokhobina, Natalia ; Ametov, Alexander ; Tu, Shih-Te ; Yang, Chwen-Yi ; Lee, I-Te ; Huang, Chien-Ning ; Ou, Horng-Yih ; Freeman, George ; Machineni, Sriram ; Klein, Klara ; Sultan, Senan ; Parsa, Alan ; Otero-Martinez, Juan ; Gonzalez, Alex ; Bhargava, Anuj ; Brian, Susan ; Ince, Carlos ; Plantholt, Stephen ; Cole, Jeremy ; Lacour, Audrey ; Vega, Damaris ; de Souza, Jose ; Rohlf, Jane L. ; St. John, Roy C. ; Horowitz, Barry ; Audish, Hanid ; Galindo, Rodolfo ; Umpiperrez, Guillermo ; Ard, Jamy ; Curtis, Brian ; Garvey, William T. ; Fraser, Neil J. ; Mandry, Jose ; Mohseni, Rizwana ; Mayfield, Ronald ; Powell, Talessa ; Vance, Carl ; Ong, Stephen ; Lewy-Alterbaum, Ana L. ; Murray, Alexander ; Al-Karadsheh, Amer ; Yacoub, Tamer ; Roberts, Kevin ; Fried, David L. ; Rosenstock, Julio ; Pulla, Bharathi ; Bode, Bruce ; Frias, Juan ; Klaff, Leslie ; Brazg, Ronald ; Van, Joanna ; Tan, Anjanette ; Briskin, Toby ; Rhee, Margaret ; Chaicha-Brom, Tira ; Hartley, Paul A. ; Nunez, Lazaro ; Cortes-Maisonet, Gregorio ; Soucie, Gary ; Hsia, Stanley ; Jones, Thomas
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2023-08, Vol.402 (10402), p.613-626
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Tirzepatide Once Weekly for the Treatment of Obesity
Author / Creator:Jastreboff, Ania M. ; Aronne, Louis J. ; Ahmad, Nadia N. ; Wharton, Sean ; Connery, Lisa ; Alves, Breno ; Kiyosue, Arihiro ; Zhang, Shuyu ; Liu, Bing ; Bunck, Mathijs C. ; Stefanski, Adam
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2022-07, Vol.387 (3), p.205-216
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Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
Author / Creator:Frias, Juan Pablo ; Nauck, Michael A ; Van, Joanna ; Kutner, Mark E ; Cui, Xuewei ; Benson, Charles ; Urva, Shweta ; Gimeno, Ruth E ; Milicevic, Zvonko ; Robins, Deborah ; Haupt, Axel
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2018-11, Vol.392 (10160), p.2180-2193
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Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis
Author / Creator:Loomba, Rohit ; Hartman, Mark L. ; Lawitz, Eric J. ; Vuppalanchi, Raj ; Boursier, Jérôme ; Bugianesi, Elisabetta ; Yoneda, Masato ; Behling, Cynthia ; Cummings, Oscar W. ; Tang, Yuanyuan ; Brouwers, Bram ; Robins, Deborah A. ; Nikooie, Amir ; Bunck, Mathijs C. ; Haupt, Axel ; Sanyal, Arun J.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2024-07, Vol.391 (4), p.299-310
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Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes
Author / Creator:Frías, Juan P ; Davies, Melanie J ; Rosenstock, Julio ; Pérez Manghi, Federico C ; Fernández Landó, Laura ; Bergman, Brandon K ; Liu, Bing ; Cui, Xuewei ; Brown, Katelyn
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2021-08, Vol.385 (6), p.503-515
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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
Author / Creator:Rosenstock, Julio ; Frias, Juan ; Jastreboff, Ania M ; Du, Yu ; Lou, Jitong ; Gurbuz, Sirel ; Thomas, Melissa K ; Hartman, Mark L ; Haupt, Axel ; Milicevic, Zvonko ; Coskun, Tamer
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2023-08, Vol.402 (10401), p.529-544
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Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial
Author / Creator:Wadden, Thomas A. ; Chao, Ariana M. ; Machineni, Sriram ; Kushner, Robert ; Ard, Jamy ; Srivastava, Gitanjali ; Halpern, Bruno ; Zhang, Shuyu ; Chen, Jiaxun ; Bunck, Mathijs C. ; Ahmad, Nadia N. ; Forrester, Tammy
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2023-11, Vol.29 (11), p.2909-2918
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The expanding incretin universe: from basic biology to clinical translation
Author / Creator:Drucker, Daniel J. ; Holst, Jens J.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2023-10, Vol.66 (10), p.1765-1779
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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity
Author / Creator:Packer, Milton ; Zile, Michael R. ; Kramer, Christopher M. ; Baum, Seth J. ; Litwin, Sheldon E. ; Menon, Venu ; Ge, Junbo ; Weerakkody, Govinda J. ; Ou, Yang ; Bunck, Mathijs C. ; Hurt, Karla C. ; Murakami, Masahiro ; Borlaug, Barry A.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2025-01, Vol.392 (5), p.427-437
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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial
Author / Creator:Urva, Shweta ; Coskun, Tamer ; Loh, Mei Teng ; Du, Yu ; Thomas, Melissa K ; Gurbuz, Sirel ; Haupt, Axel ; Benson, Charles T ; Hernandez-Illas, Martha ; D’Alessio, David A ; Milicevic, Zvonko
Publisher:London: Elsevier Ltd
Journal title:The Lancet (British edition), 2022-11, Vol.400 (10366), p.1869-1881
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Incretin hormones and type 2 diabetes
Author / Creator:Nauck, Michael A. ; Müller, Timo D.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2023-10, Vol.66 (10), p.1780-1795
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Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
Author / Creator:Hammoud, Rola ; Drucker, Daniel J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2023-04, Vol.19 (4), p.201-216
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Tirzepatide: First Approval
Author / Creator:Syed, Yahiya Y.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2022-07, Vol.82 (11), p.1213-1220
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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
Author / Creator:Zhao, Fenghui ; Zhou, Qingtong ; Cong, Zhaotong ; Hang, Kaini ; Zou, Xinyu ; Zhang, Chao ; Chen, Yan ; Dai, Antao ; Liang, Anyi ; Ming, Qianqian ; Wang, Mu ; Chen, Li-Nan ; Xu, Peiyu ; Chang, Rulve ; Feng, Wenbo ; Xia, Tian ; Zhang, Yan ; Wu, Beili ; Yang, Dehua ; Zhao, Lihua ; Xu, H. Eric ; Wang, Ming-Wei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.1057-1057, Article 1057
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Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
Author / Creator:Killion, Elizabeth A. ; Chen, Michelle ; Falsey, James R. ; Sivits, Glenn ; Hager, Todd ; Atangan, Larissa ; Helmering, Joan ; Lee, Jae ; Li, Hongyan ; Wu, Bin ; Cheng, Yuan ; Véniant, Murielle M. ; Lloyd, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-10, Vol.11 (1), p.4981-4981, Article 4981
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Therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment

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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

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Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

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Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-grou...

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Retraction Note: therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment

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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

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Tirzepatide Once Weekly for the Treatment of Obesity

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Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

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Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

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Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

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Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

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The expanding incretin universe: from basic biology to clinical translation

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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

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Incretin hormones and type 2 diabetes

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Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1

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Tirzepatide: First Approval

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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

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Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

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