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ArticlesPeer ReviewedFull Text
PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection
Author / Creator:Salimzadeh, Loghman ; Le Bert, Nina ; Dutertre, Charles-A ; Gill, Upkar S ; Newell, Evan W ; Frey, Christian ; Hung, Magdeleine ; Novikov, Nikolai ; Fletcher, Simon ; Kennedy, Patrick Tf ; Bertoletti, Antonio
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4573-4587
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Circulating and intrahepatic antiviral B cells are defective in hepatitis B
Author / Creator:Burton, Alice R ; Pallett, Laura J ; McCoy, Laura E ; Suveizdyte, Kornelija ; Amin, Oliver E ; Swadling, Leo ; Alberts, Elena ; Davidson, Brian R ; Kennedy, Patrick Tf ; Gill, Upkar S ; Mauri, Claudia ; Blair, Paul A ; Pelletier, Nadege ; Maini, Mala K
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4588-4603
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Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver
Author / Creator:Jo, Juandy ; Tan, Anthony T ; Ussher, James E ; Sandalova, Elena ; Tang, Xin-Zi ; Tan-Garcia, Alfonso ; To, Natalie ; Hong, Michelle ; Chia, Adeline ; Gill, Upkar S ; Kennedy, Patrick T ; Tan, Kai Chah ; Lee, Kang Hoe ; De Libero, Gennaro ; Gehring, Adam J ; Willberg, Christian B ; Klenerman, Paul ; Bertoletti, Antonio
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2014-06, Vol.10 (6), p.e1004210
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Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
Author / Creator:Pallett, Laura J ; Gill, Upkar S ; Quaglia, Alberto ; Sinclair, Linda V ; Jover-Cobos, Maria ; Schurich, Anna ; Singh, Kasha P ; Thomas, Niclas ; Das, Abhishek ; Chen, Antony ; Fusai, Giuseppe ; Bertoletti, Antonio ; Cantrell, Doreen A ; Kennedy, Patrick T ; Davies, Nathan A ; Haniffa, Muzlifah ; Maini, Mala K
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-06, Vol.21 (6), p.591-600
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Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
Author / Creator:Svicher, Valentina ; Salpini, Romina ; Piermatteo, Lorenzo ; Carioti, Luca ; Battisti, Arianna ; Colagrossi, Luna ; Scutari, Rossana ; Surdo, Matteo ; Cacciafesta, Valeria ; Nuccitelli, Andrea ; Hansi, Navjyot ; Ceccherini Silberstein, Francesca ; Perno, Carlo Federico ; Gill, Upkar S ; Kennedy, Patrick T F
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2021-12, Vol.70 (12), p.2337-2348
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Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo
Author / Creator:Gill, Upkar S ; Peppa, Dimitra ; Micco, Lorenzo ; Singh, Harsimran D ; Carey, Ivana ; Foster, Graham R ; Maini, Mala K ; Kennedy, Patrick T F
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2016-08, Vol.12 (8), p.e1005788-e1005788
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The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells
Author / Creator:Schurich, Anna ; Pallett, Laura J ; Lubowiecki, Marcin ; Singh, Harsimran D ; Gill, Upkar S ; Kennedy, Patrick T ; Nastouli, Eleni ; Tanwar, Sudeep ; Rosenberg, William ; Maini, Mala K
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-03, Vol.9 (3), p.e1003208-e1003208
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Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma
Author / Creator:Zaki, Marco Y W ; Fathi, Ahmed M ; Samir, Samara ; Eldafashi, Nardeen ; William, Kerolis Y ; Nazmy, Maiiada Hassan ; Fathy, Moustafa ; Gill, Upkar S ; Shetty, Shishir
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2022-02, Vol.14 (5), p.1255
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Early Treatment Consideration in Patients with Hepatitis B 'e' Antigen-Positive Chronic Infection: Is It Time for a Paradigm Shift?
Author / Creator:Koffas, Apostolos ; Mak, Lung-Yi ; Gill, Upkar S ; Kennedy, Patrick T F
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2022-04, Vol.14 (5), p.900
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TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
Author / Creator:Singh, Harsimran D. ; Otano, Itziar ; Rombouts, Krista ; Singh, Kasha P. ; Peppa, Dimitra ; Gill, Upkar S. ; Böttcher, Katrin ; Kennedy, Patrick T. F. ; Oben, Jude ; Pinzani, Massimo ; Walczak, Henning ; Fusai, Giuseppe ; Rosenberg, William M. C. ; Maini, Mala K.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-07, Vol.7 (1), p.5514-11, Article 5514
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HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven...
Author / Creator:Piermatteo, Lorenzo ; Alkhatib, Mohammad ; D’Anna, Stefano ; Malagnino, Vincenzo ; Bertoli, Ada ; Andreassi, Eleonora ; Basile, Elisa ; Iuvara, Alessandra ; De Cristofaro, Maria ; Cappiello, Giuseppina ; Cerva, Carlotta ; Minichini, Carmine ; Pisaturo, Mariantonietta ; Starace, Mario ; Coppola, Nicola ; Fontana, Carla ; Grelli, Sandro ; Ceccherini-Silberstein, Francesca ; Andreoni, Massimo ; Gill, Upkar S. ; Kennedy, Patrick T. F. ; Sarmati, Loredana ; Salpini, Romina ; Svicher, Valentina
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2021-09, Vol.9 (10), p.1352
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ArticlesPeer ReviewedFull Text
Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg...
Author / Creator:Salpini, Romina ; Battisti, Arianna ; Piermatteo, Lorenzo ; Carioti, Luca ; Anastasiou, Olympia E. ; Gill, Upkar S. ; Di Carlo, Domenico ; Colagrossi, Luna ; Duca, Leonardo ; Bertoli, Ada ; La Rosa, Katia Yu ; Fabeni, Lavinia ; Iuvara, Alessandra ; Malagnino, Vincenzo ; Cerva, Carlotta ; Lichtner, Miriam ; Mastroianni, Claudio M. ; De Sanctis, Giuseppe Maria ; Paoloni, Maurizio ; Marignani, Massimo ; Pasquazzi, Caterina ; Iapadre, Nerio ; Parruti, Giustino ; Vecchiet, Jacopo ; Sarmati, Loredana ; Andreoni, Massimo ; Angelico, Mario ; Grelli, Sandro ; T. Kennedy, Patrick ; Verheyen, Jens ; Aquaro, Stefano ; Ceccherini-Silberstein, Francesca ; Perno, Carlo Federico ; Svicher, Valentina
Publisher:United States: Taylor & Francis
Journal title:Emerging microbes & infections, 2020-01, Vol.9 (1), p.928-939
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Prioritisation and the initiation of HCC surveillance in CHB patients: lessons to learn from the COVID-19 crisis
Author / Creator:Zeng, Georgia ; Gill, Upkar S ; Kennedy, Patrick T F
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2020-11, Vol.69 (11), p.1907-1912
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Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation
Author / Creator:Rivino, Laura ; Le Bert, Nina ; Gill, Upkar S ; Kunasegaran, Kamini ; Cheng, Yang ; Tan, Damien Zm ; Becht, Etienne ; Hansi, Navjyot K ; Foster, Graham R ; Su, Tung-Hung ; Tseng, Tai-Chung ; Lim, Seng Gee ; Kao, Jia-Horng ; Newell, Evan W ; Kennedy, Patrick Tf ; Bertoletti, Antonio
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-02, Vol.128 (2), p.668-681
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Liver sampling: a vital window into HBV pathogenesis on the path to functional cure
Author / Creator:Gill, Upkar S ; Pallett, Laura J ; Kennedy, Patrick T F ; Maini, Mala K
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2018-04, Vol.67 (4), p.767-775
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Fine needle aspirates comprehensively sample intrahepatic immunity
Author / Creator:Gill, Upkar S ; Pallett, Laura J ; Thomas, Niclas ; Burton, Alice R ; Patel, Amit A ; Yona, Simon ; Kennedy, Patrick T F ; Maini, Mala K
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2019-08, Vol.68 (8), p.1493-1503
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IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline
Author / Creator:Knight, Connor H ; Khan, Faraz ; Patel, Ankit ; Gill, Upkar S ; Okosun, Jessica ; Wang, Jun
Publisher:England: Oxford University Press
Journal title:Briefings in bioinformatics, 2023-03, Vol.24 (2)
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The human liver microenvironment shapes the homing and function of CD4+ T-cell populations
Author / Creator:Wiggins, Benjamin G ; Pallett, Laura J ; Li, Xiaoyan ; Davies, Scott P ; Amin, Oliver E ; Gill, Upkar S ; Kucykowicz, Stephanie ; Patel, Arzoo M ; Aliazis, Konstantinos ; Liu, Yuxin S ; Reynolds, Gary M ; Davidson, Brian R ; Gander, Amir ; Luong, Tu Vinh ; Hirschfield, Gideon M ; Kennedy, Patrick T F ; Huang, Yuehua ; Maini, Mala K ; Stamataki, Zania
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2022-07, Vol.71 (7), p.1399-1411
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Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS
Author / Creator:Pallett, Laura J. ; Swadling, Leo ; Diniz, Mariana ; Maini, Alexander A. ; Schwabenland, Marius ; Gasull, Adrià Dalmau ; Davies, Jessica ; Kucykowicz, Stephanie ; Skelton, Jessica K. ; Thomas, Niclas ; Schmidt, Nathalie M. ; Amin, Oliver E. ; Gill, Upkar S. ; Stegmann, Kerstin A. ; Burton, Alice R. ; Stephenson, Emily ; Reynolds, Gary ; Whelan, Matt ; Sanchez, Jenifer ; de Maeyer, Roel ; Thakker, Clare ; Suveizdyte, Kornelija ; Uddin, Imran ; Ortega-Prieto, Ana M. ; Grant, Charlotte ; Froghi, Farid ; Fusai, Giuseppe ; Lens, Sabela ; Pérez-del-Pulgar, Sofia ; Al-Akkad, Walid ; Mazza, Giuseppe ; Noursadeghi, Mahdad ; Akbar, Arne ; Kennedy, Patrick T. F. ; Davidson, Brian R. ; Prinz, Marco ; Chain, Benjamin M. ; Haniffa, Muzlifah ; Gilroy, Derek W. ; Dorner, Marcus ; Bengsch, Bertram ; Schurich, Anna ; Maini, Mala K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-02, Vol.614 (7947), p.334-342
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ArticlesPeer ReviewedFull Text
Assessment of Bone Mineral Density in Tenofovir-Treated Patients With Chronic Hepatitis B: Can the Fracture Risk Assessment Tool Identify Those at Greatest Risk?
Author / Creator:Gill, Upkar S. ; Zissimopoulos, Alexandra ; Al-Shamma, Safa ; Burke, Katherine ; McPhail, Mark J. W. ; Barr, David A. ; Kallis, Yiannis N. ; Marley, Richard T. C. ; Kooner, Paul ; Foster, Graham R. ; Kennedy, Patrick T. F.
Publisher:United States: Oxford University Press
Journal title:The Journal of infectious diseases, 2015-02, Vol.211 (3), p.374-382
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PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

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Circulating and intrahepatic antiviral B cells are defective in hepatitis B

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Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver

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Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

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Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

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Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo

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The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells

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Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma

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Early Treatment Consideration in Patients with Hepatitis B 'e' Antigen-Positive Chronic Infection: Is It Time for a Paradigm Shift?

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TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

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HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven...

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Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg...

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Prioritisation and the initiation of HCC surveillance in CHB patients: lessons to learn from the COVID-19 crisis

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Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation

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Liver sampling: a vital window into HBV pathogenesis on the path to functional cure

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Fine needle aspirates comprehensively sample intrahepatic immunity

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IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline

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The human liver microenvironment shapes the homing and function of CD4+ T-cell populations

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Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS

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Assessment of Bone Mineral Density in Tenofovir-Treated Patients With Chronic Hepatitis B: Can the Fracture Risk Assessment Tool Identify Those at Greatest Risk?

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