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ArticlesPeer ReviewedFull Text
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Author / Creator:Flaherty, Keith T ; Puzanov, Igor ; Kim, Kevin B ; Ribas, Antoni ; McArthur, Grant A ; Sosman, Jeffrey A ; O'Dwyer, Peter J ; Lee, Richard J ; Grippo, Joseph F ; Nolop, Keith ; Chapman, Paul B
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2010-08, Vol.363 (9), p.809-819
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A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers
Author / Creator:Luk, Andrea ; Jiang, Qiudi ; Glavini, Katerina ; Triyatni, Miriam ; Zhao, Na ; Racek, Tomas ; Zhu, Yonghong ; Grippo, Joseph F.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2020-09, Vol.13 (5), p.985-993
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Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like re...
Author / Creator:Jiang, Qiudi ; Zhang, Yuchen ; Duan, Dan ; Retout, Sylvie ; Upmanyu, Ruchi ; Glavini, Katerina ; Triyatni, Miriam ; Zhu, Yonghong ; Grippo, Joseph F. ; Jin, Yuyan
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2024-08, Vol.17 (8), p.e13896-n/a
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
Author / Creator:Grippo, Joseph F. ; Folitar, Ilia ; Passe, Sharon ; Jiang, Qiudi ; Rodriguez, Ignacio ; Fettner, Scott H. ; Calleja, Elizabeth
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2021-07, Vol.14 (4), p.1524-1534
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A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers
Author / Creator:Cheung, Tsang Tommy ; Luk, Andrea On Yan ; Zhang, Yuchen ; Pavlovic, Vedran ; Wat, Cynthia ; Das, Sudip ; Surujbally, Bernadette ; Triyatni, Miriam ; Grippo, Joseph F.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2023-07, Vol.16 (7), p.1272-1282
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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Author / Creator:Grimsby, Joseph ; Sarabu, Ramakanth ; Corbett, Wendy L. ; Haynes, Nancy-Ellen ; Bizzarro, Fred T. ; Coffey, John W. ; Guertin, Kevin R. ; Hilliard, Darryl W. ; Kester, Robert F. ; Mahaney, Paige E. ; Marcus, Linda ; Qi, Lida ; Spence, Cheryl L. ; Tengi, John ; Magnuson, Mark A. ; Chu, Chang An ; Dvorozniak, Mark T. ; Matschinsky, Franz M. ; Grippo, Joseph F.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2003-07, Vol.301 (5631), p.370-373
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ArticlesPeer ReviewedFull Text
Clinical Pharmacokinetics of Vemurafenib
Author / Creator:Zhang, Weijiang ; Heinzmann, Dominik ; Grippo, Joseph F.
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2017-09, Vol.56 (9), p.1033-1043
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Evaluation of the Absolute Bioavailability of Pegylated Interferon Alfa-2a After Subcutaneous Administration to Healthy Male Volunteers: An Open-Label, Randomized, Parallel-Group Study
Author / Creator:Brennan, Barbara J., PharmD ; Xu, Zhi-Xin, MD, PhD ; Grippo, Joseph F., PhD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2012-09, Vol.34 (9), p.1883-1891
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Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes
Author / Creator:SHIOTA, Masakazu ; POSTIC, Catherine ; FUJIMOTO, Yuka ; JETTON, Thomas L ; DIXON, Kathryn ; PAN, Danhua ; GRIMSBY, Joseph ; GRIPPO, Joseph F ; MAGNUSON, Mark A ; CHERRINGTON, Alan D
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2001-03, Vol.50 (3), p.622-629
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ArticlesPeer ReviewedFull Text
A single‐dose mass balance and metabolite‐profiling study of vemurafenib in patients with metastatic melanoma
Author / Creator:Goldinger, Simone M. ; Rinderknecht, Jeannine ; Dummer, Reinhard ; Kuhn, Felix Pierre ; Yang, Kuo‐Hsiung ; Lee, Lucy ; Ayala, Ruben C. ; Racha, Jagdish ; Geng, Wanping ; Moore, David ; Liu, Mei ; Joe, Andrew K. ; Bazan, Selby Patricia Gil ; Grippo, Joseph F.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Pharmacology research & perspectives, 2015-03, Vol.3 (2), p.e00113-n/a
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ArticlesPeer ReviewedFull Text
Two nuclear signalling pathways for vitamin D
Author / Creator:Carlberg, Carsten ; Bendik, Igor ; Wyss, Adrian ; Meier, Elke ; Sturzenbecker, Laurie J. ; Grippo, Joseph F. ; Hunziker, Willi
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 1993-02, Vol.361 (6413), p.657-660
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ArticlesPeer ReviewedFull Text
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
Author / Creator:Levin, Arthur A. ; Sturzenbecker, Laurie J. ; Kazmer, Sonja ; Bosakowski, Thomas ; Huselton, Christine ; Allenby, Gary ; Speck, Jeffrey ; ratzeisen, Cl ; Rosenberger, Michael ; Lovey, Allen ; Grippo, Joseph F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 1992-01, Vol.355 (6358), p.359-361
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ArticlesPeer ReviewedFull Text
Retinoic Acid Receptors and Retinoid X Receptors: Interactions with Endogenous Retinoic Acids
Author / Creator:Allenby, Gary ; Bocquel, Marie-Therese ; Saunders, Michael ; Kazmer, Sonja ; Speck, Jeffrey ; Rosenberger, Michael ; Lovey, Allen ; Kastner, Philippe ; Grippo, Joseph F. ; Chambon, Pierre ; Levin, Arthur A.
Publisher:Washington, DC: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1993-01, Vol.90 (1), p.30-34
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ArticlesPeer ReviewedFull Text
Glucokinase Contains Two Leucine-Rich Nuclear Export Signals
Author / Creator:SHIOTA, CHIYO ; GRIPPO, JOSEPH F ; MAGNUSON, MARK A
Publisher:American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 1999-05, Vol.48 (5), p.SA262
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ArticlesPeer ReviewedFull Text
Characterization of Glucokinase Regulatory Protein Deficient Mice
Author / Creator:GRIMSBY, JOSEPH ; COFFEY, JOHN W ; DVOROZNIAK, MARK T ; LI, GUIZHU ; MATSCHINSKY, FRANZ M ; SHIOTA, CHIYO ; MAGNUSON, MARK A ; GRIPPO, JOSEPH F
Publisher:American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 1999-05, Vol.48 (5), p.SA402
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ArticlesPeer ReviewedFull Text
Identification and Characterization of Nuclear Retionic Acid-Binding Activity in Human Myeloblastic Leukemia HL-60 Cells
Author / Creator:Nervi, Clara ; Grippo, Joseph F. ; Sherman, Michael I. ; George, Margaret D. ; Jetten, Anton M.
Publisher:National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1989-08, Vol.86 (15), p.5854-5858
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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers

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Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like re...

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

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A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers

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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

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Clinical Pharmacokinetics of Vemurafenib

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Evaluation of the Absolute Bioavailability of Pegylated Interferon Alfa-2a After Subcutaneous Administration to Healthy Male Volunteers: An Open-Label, Randomized, Parallel-Group Study

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Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes

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A single‐dose mass balance and metabolite‐profiling study of vemurafenib in patients with metastatic melanoma

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Two nuclear signalling pathways for vitamin D

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9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

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Retinoic Acid Receptors and Retinoid X Receptors: Interactions with Endogenous Retinoic Acids

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Glucokinase Contains Two Leucine-Rich Nuclear Export Signals

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Characterization of Glucokinase Regulatory Protein Deficient Mice

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Identification and Characterization of Nuclear Retionic Acid-Binding Activity in Human Myeloblastic Leukemia HL-60 Cells

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