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ArticlesPeer ReviewedFull Text
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Author / Creator:Firestein, Ron ; Blander, Gil ; Michan, Shaday ; Oberdoerffer, Philipp ; Ogino, Shuji ; Campbell, Jennifer ; Bhimavarapu, Anupama ; Luikenhuis, Sandra ; de Cabo, Rafael ; Fuchs, Charles ; Hahn, William C. ; Guarente, Leonard P. ; Sinclair, David A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2008-04, Vol.3 (4), p.e2020-e2020
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ArticlesPeer ReviewedFull Text
Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of...
Author / Creator:Simic, Petra ; Vela Parada, Xavier Fernando ; Parikh, Samir M. ; Dellinger, Ryan ; Guarente, Leonard P. ; Rhee, Eugene P.
Publisher:England: BioMed Central
Journal title:BMC nephrology, 2020-08, Vol.21 (1), p.342-342, Article 342
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ArticlesPeer ReviewedFull Text
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice
Author / Creator:Hayashi, Hideki ; Cherpokova, Deya ; Martinod, Kimberly ; Witsch, Thilo ; Wong, Siu Ling ; Gallant, Maureen ; Cifuni, Stephen M. ; Guarente, Leonard P. ; Wagner, Denisa D.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-12, Vol.12 (12), p.e0188341-e0188341
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ArticlesPeer ReviewedFull Text
Dietary Restriction: Standing Up for Sirtuins [With Response]
Author / Creator:BAUR, JOEPH A. ; CHEN, DANICA ; CHINI, EDUARDO N. ; CHUA, KATRIN ; COHEN, HAIM Y. ; DE CABO, RAFAEL ; DENG, CHUXIA ; DIMMELER, STEFANIE ; GIUS, DAVID ; GUARENTE, LEONARD P. ; HELFAND, STEPHEN L. ; IMAI, SHIN-ICHIRO ; ITOH, HIROSHI ; KADOWAKI, TAKASHI ; KOYA, DAISUKE ; LEEUWENBURGH, CHRISTIAAN ; MCBURNEY, MICHAEL ; NABESHIMA, YO-ICHI ; NERI, CHRISTIAN ; OBERDOERFFER, PHILIPP ; PESTELL, RICHARD G. ; ROGINA, BLANKA ; SADOSHIMA, JUNICHI ; SARTORELLI, VITTORIO ; SERRANO, MANUEL ; SINCLAIR, DAVID A. ; STEEGBORN, CLEMENS ; TATAR, MARC ; TISSENBAUM, HEIDI A. ; TONG, QIANG ; TSUBOTA, KAZUO ; VAQUERO, ALEJANDRO ; VERDIN, ERIC ; FONTANA, LUIGI ; PARTRIDGE, LINDA ; LONGO, VALTER D.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-08, Vol.329 (5995), p.1012-1014
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ArticlesPeer ReviewedFull Text
SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
Author / Creator:Herskovits, Adrianna Z. ; Hunter, Tegan A. ; Maxwell, Nicholas ; Pereira, Katherine ; Whittaker, Charles A. ; Valdez, Gregorio ; Guarente, Leonard P.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2018-12, Vol.17 (6), p.e12839-n/a
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Newsletter articlesFull Text
Sirtris Pharmaceuticals Scientific Advisor Shows SIRT1 Activation Improves Huntington's Disease In Preclinical Model
Publisher:NewsRX LLC
Journal title:Science Letter, 2008, p.4170-4170
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ArticlesPeer ReviewedFull Text
Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Author / Creator:Firestein, Ron ; Blander, Gil ; Michan, Shaday ; Oberdoerffer, Philipp ; Ogino, Shuji ; Campbell, Jennifer ; Bhimavarapu, Anupama ; Luikenhuis, Sandra ; de Cabo, Rafael ; Fuchs, Charles ; Hahn, William C. ; Guarente, Leonard P. ; Sinclair, David A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-06, Vol.19 (6), p.e0305277
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If an MIT scientist discovered the fountain of youth, would you believe him?
Author / Creator:Wallace, Benjamin
Publisher:Vox Media, LLC
Journal title:New York (1968), 2016-08, p.56
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ArticlesPeer ReviewedFull Text
Changes in telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae
Author / Creator:Austriaco, N.R. Jr ; Guarente, L.P
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (18), p.9768-9772
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ReviewsPeer ReviewedFull Text
Molecular Biology of Aging
Author / Creator:Ackermann, Martin
Publisher:Baltimore: The University of Chicago Press
Journal title:The Quarterly review of biology, 2008, Vol.83 (4), p.402-403
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CAN THIS PILL CHANGE YOUR LIFE? The secret to good health at every age may already be within our bodies. But have the world-renowned researchers at Elysium Health actually developed a way to activate...
Publisher:Hearst Magazines, a Division of the Hearst Corporation
Journal title:Good housekeeping (U.S. ed.), 2019-01, Vol.268 (1), p.70
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ArticlesPeer ReviewedFull Text
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
Author / Creator:Jeong, Hyunkyung ; Cohen, Dena E ; Cui, Libin ; Supinski, Andrea ; Savas, Jeffrey N ; Mazzulli, Joseph R ; Yates, John R ; Bordone, Laura ; Guarente, Leonard ; Krainc, Dimitri
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-01, Vol.18 (1), p.159-165
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ArticlesPeer ReviewedFull Text
Nicotinamide riboside with pterostilbene : a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Author / Creator:Simic, Petra ; Vela Parada, Xavier Fernando ; Parikh, Samir M ; Dellinger, Ryan ; Guarente, Leonard P ; Rhee, Eugene P
Publisher:BioMed Central Ltd
Journal title:BMC nephrology, 2020-08, Vol.21 (1)
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ArticlesFull Text
Forestalling the Great Beyond with the Help of SIR2
Author / Creator:Guarente, Leonard P
Publisher:Midland: LabX Media Group
Journal title:The Scientist, 2004-04, Vol.18 (8), p.34
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ArticlesFull Text
Forestalling the great beyond with the help of SIR2: a simple genetic program might be altered to prolong and improve life
Author / Creator:Guarente, Leonard P
Publisher:Scientist Inc
Journal title:The Scientist (Philadelphia, Pa.), 2004-04, Vol.18 (8), p.34
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ArticlesPeer ReviewedFull Text
Mutant RNA Polymerase of Escherichia coli Terminates Transcription in Strains Making Defective Rho Factor
Author / Creator:Guarente, Leonard P. ; Beckwith, Jon
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1978-01, Vol.75 (1), p.294-297
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The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

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Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of...

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Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice

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Dietary Restriction: Standing Up for Sirtuins [With Response]

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SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis

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Sirtris Pharmaceuticals Scientific Advisor Shows SIRT1 Activation Improves Huntington's Disease In Preclinical Model

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Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

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If an MIT scientist discovered the fountain of youth, would you believe him?

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Changes in telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae

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Molecular Biology of Aging

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CAN THIS PILL CHANGE YOUR LIFE? The secret to good health at every age may already be within our bodies. But have the world-renowned researchers at Elysium Health actually developed a way to activate...

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Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

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Nicotinamide riboside with pterostilbene : a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

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Forestalling the Great Beyond with the Help of SIR2

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Forestalling the great beyond with the help of SIR2: a simple genetic program might be altered to prolong and improve life

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Mutant RNA Polymerase of Escherichia coli Terminates Transcription in Strains Making Defective Rho Factor

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