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1. The Sun-Herald City2Surf fun run, William Street, Sydney, 12 August 2012
2. Chandelier stage setting for La Traviata, Handa Opera on Sydney Harbour, 22 March 2012
3. Emma Matthews and chorus, Sempera libera from La Traviata, Handa Opera on Sydney Harbour, 22 March 2012
4. Dragon, Chinese New Year Twilight Parade, George Street, Sydney, 17 February 2013
5. Indigenous Aria winner Geoffrey Gurrumul Yunupingu, Homebake, Domain, Sydney, 3 December 2011
6. Lee Cheng Wei (Malaysia), Australian Open Badminton, Darling Harbour, 2 April 2013
7. Equal marriage rights supporters, Sydney Mardi Gras, 2 March 2013
8. Dykes on Bikes, Sydney Mardi Gras, 2 March 2013
9. Rachel Couper and Ivana Kuzmanovska dome sculpture Mirador, Sculpture by the Sea, Marks Park, Bondi, 12 November 2012
10. Julian Assange supporters, Sydney Mardi Gras, 2 March 2013
11. Designer Leah Madden and models, White Sands swimwear, Mercedes Benz Fashion Week Australia, 8 April 2013
12. Romance was Born parade, Mercedes Benz Fashion Week Australia, Carriageworks, 8 April 2013
13. New Greenpeace Rainbow Warrior, Sydney Harbour, 24 March 2013
14. Romance was Born parade,  Mercedes Benz Fashion Week Australia, 8 April 2013
15. New Year's Eve fireworks, Sydney Harbour Bridge, 31/12/2012
16. Jessica Mauboy, Australian Academy Cinema Television Arts (AACTA) awards winner, Star Casino, 31 January 2013
17. Waxworks celebrating Madame Tussauds first birthday in Sydney, Mrs Macquaries Point, 17 April 2013
18. Regional Express (Rex) Saab 340B, Kingsford Smith Airport, 11 January 2013
19. Dawn service, Cenotaph, Anzac Day, 25 April 2013
20. Lee Cheng Wei (Malaysia) versus Tian Houwei (China), Australian Open Badminton, Day 5, Darling Harbour, 6 April 2013
21. Tian Houwei (China), winner Australian Open Badminton, Darling Harbour, 7 April 2013
22. Qantas Boeing 737 and Airbus A380, Kingsford Smith Airport, 7 October 2012
23. Qantas Airbus A380 Reginald Duigan, Kingsford Smith Airport, 14 October 2012
24. New Air Ambulance Nancy Bird Walton, Beechcraft Super King Air 350, Kingsford Smith Airport, 24 November 2012

Collection 08: Events, celebrities, celebrations and performances in Sydney, 2011-2013 / photographed by Robert Wallace

Vertebrate kidneys contain nephron functional units where specialized epithelial cell types are organized into segments with discrete physiological roles. Many gaps remain in our understanding of how segment regions develop. Here, we report that the transcription factor
empty spiracles homeobox gene 1
(
emx1
) is a novel nephron segment regulator during embryonic kidney development in zebrafish.
emx1
loss of function altered the domains of distal segments without changes in cell turnover or traits like size and morphology, indicating that
emx1
directs distal segment fates during nephrogenesis. In exploring how
emx1
influences nephron patterning, we found that retinoic acid (RA), a morphogen that induces proximal and represses distal segments, negatively regulates
emx1
expression. Next, through a series of genetic studies, we found that
emx1
acts downstream of a cascade involving
mecom
and
tbx2b
, which encode essential distal segment transcription factors. Finally, we determined that
emx1
regulates the expression domains of
irx3b
and
irx1a
to control distal segmentation, and
sim1a
to control corpuscle of Stannius formation. Taken together, our work reveals for the first time that
emx1
is a key component of the pronephros segmentation network, which has implications for understanding the genetic regulatory cascades that orchestrate vertebrate nephron patterning.

Scientific reports, 2018-12, Vol.8 (1), p.18038-17, Article 18038

Homeogene emx1 is required for nephron distal segment development in zebrafish

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an institutionally developed system for prostate cancer detection, grading, and workflow optimization and to contrast this with commercial alternatives. From August 2021 to March 2023, we scanned 21,396 slides from 1,147 patients with positive biopsies. We developed models for cancer detection, grading, and screening of equivocal cases for IHC ordering. We compared a task-specific model trained using the PANDA dataset of prostate cancer biopsies with one built using features extracted by the general-purpose histology foundation model, UNI and compare their performance in an unfiltered prospectively collected dataset that reflects our patient population (1737 slides,95 patients). We evaluated the contributions of a bespoke model designed to improve sensitivity in detecting small cancer foci and scoring of broader patterns observed at lower resolution. We found high concordance between the developed systems and pathologist reference in detection (AUC 98.5, sensitivity 95.0, and specificity 97.8), ISUP grading (quadratic Cohen's kappa 0.869), grade group 3 or higher (AUC 97.5, sensitivity 94.9, specificity 96.6) and comparable to published data from commercial systems. Screening could reduce IHC ordering for equivocal cases by 44.5% with an overall error rate of 1.8% (1.4% false positive, 0.4% false negative rates). Institutions like academic medical centers that have high scanning volumes and report abstraction capabilities can develop accurate computational pathology models for internal use. These models have the potential to aid in quality control role and to improve workflow in the pathology lab to help meet future challenges in prostate cancer diagnosis.

arXiv.org, 2024-10

Novel Clinical-Grade Prostate Cancer Detection and Grading Model: Development and Prospective Validation Using Real World Data, with Performance Assessment on IHC Requested Cases

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Collection 08: Events, celebrities, celebrations and performances in Sydney, 2011-2013 / photographed by Robert Wallace

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Homeogene emx1 is required for nephron distal segment development in zebrafish

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Novel Clinical-Grade Prostate Cancer Detection and Grading Model: Development and Prospective Validation Using Real World Data, with Performance Assessment on IHC Requested Cases

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Collection 08: Events, celebrities, celebrations and performances in Sydney, 2011-2013 / photographed by Robert Wallace

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Homeogene emx1 is required for nephron distal segment development in zebrafish

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Novel Clinical-Grade Prostate Cancer Detection and Grading Model: Development and Prospective Validation Using Real World Data, with Performance Assessment on IHC Requested Cases

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