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Sub-series 2: Angus & Robertson book reviews, loose, 1957-1972

Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drinking excessive alcohol.
Male C57BL/6J mice were given 36% alcohol in the drinking water. Those given blank water were used as control. Twelve weeks later, the phenotypic characteristics of the heart, including gap junctions and electrical properties were examined. In the alcohol group the ventricles contained a smaller size of cardiomyocytes and a higher density of capillary networks, compared to the control. Western blots showed that, after drinking alcohol, the content of connexin43 (Cx43) protein in the left ventricle was increased by 18% (p < 0.05). Consistently, immunoconfocal microscopy demonstrated that Cx43 gap junctions were up-regulated in the alcohol group with a disorganized distribution, compared to the control. Optical mapping showed that the alcohol group had a reduced conduction velocity (40 ± 18 vs 60 ± 7 cm/sec, p < 0.05) and a higher incidence of ventricular tachyarrhythmia (62% vs 30%, p < 0.05).
Long-term excessive alcohol intake resulted in extensive cardiac remodeling, including changes in expression and distribution of gap junctions, growth of capillary network, reduction of cardiomyocyte size, and decrease of myocardial conduction.

Journal of biomedical science, 2011-09, Vol.18 (1), p.72-72, Article 72

Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion

To explore resonance phenomena in the nonlinear region, we show by experimental measurements and theoretical analyses that resonance happens in modulation instability (MI) from non-instantaneous nonlinearities in photorefractive crystals. With a temporally periodic modulation in the external bias voltage, corresponding to a modulation in the nonlinear strength, an enhancement in the visibility of MI at resonant frequency is reported through spontaneous optical pattern formations. Modeled by such temporally periodic nonlinear driving force to the system, theoretical curves obtained from a nonlinear non-instantaneous Schr\"{o}dinger equation give good agreement to experimental data. As MI is a universal signature of symmetry-breaking phenomena, our observation on the resonance in MI may provide a control on chaotic, solitary, and turbulence waves.

arXiv.org, 2017-12

Resonance in modulation instability from non-instantaneous nonlinearities

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Sub-series 2: Angus & Robertson book reviews, loose, 1957-1972

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Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion

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Resonance in modulation instability from non-instantaneous nonlinearities

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