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ArticlesPeer ReviewedFull Text
Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers
Author / Creator:Sivaramakrishnan, Manaswini ; McCarthy, Kathleen D. ; Campagne, Sébastien ; Huber, Sylwia ; Meier, Sonja ; Augustin, Angélique ; Heckel, Tobias ; Meistermann, Hélène ; Hug, Melanie N. ; Birrer, Pascale ; Moursy, Ahmed ; Khawaja, Sarah ; Schmucki, Roland ; Berntenis, Nikos ; Giroud, Nicolas ; Golling, Sabrina ; Tzouros, Manuel ; Banfai, Balazs ; Duran-Pacheco, Gonzalo ; Lamerz, Jens ; Hsiu Liu, Ying ; Luebbers, Thomas ; Ratni, Hasane ; Ebeling, Martin ; Cléry, Antoine ; Paushkin, Sergey ; Krainer, Adrian R. ; Allain, Frédéric H.-T. ; Metzger, Friedrich
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1476-13, Article 1476
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Synthetic single domain antibodies for the conformational trapping of membrane proteins
Author / Creator:Zimmermann, Iwan ; Egloff, Pascal ; Hutter, Cedric Aj ; Arnold, Fabian M ; Stohler, Peter ; Bocquet, Nicolas ; Hug, Melanie N ; Huber, Sylwia ; Siegrist, Martin ; Hetemann, Lisa ; Gera, Jennifer ; Gmür, Samira ; Spies, Peter ; Gygax, Daniel ; Geertsma, Eric R ; Dawson, Roger Jp ; Seeger, Markus A
Publisher:England: eLife Sciences Publications, Ltd
Journal title:eLife, 2018-05, Vol.7
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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands
Author / Creator:Huber, Sylwia ; Casagrande, Fabio ; Hug, Melanie N ; Wang, Lisha ; Heine, Philipp ; Kummer, Lutz ; Plückthun, Andreas ; Hennig, Michael
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-05, Vol.12 (5), p.e0175842-e0175842
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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia
Author / Creator:Sewing, Sabine ; Roth, Adrian B ; Winter, Michael ; Dieckmann, Andreas ; Bertinetti-Lapatki, Cristina ; Tessier, Yann ; McGinnis, Claudia ; Huber, Sylwia ; Koller, Erich ; Ploix, Corinne ; Reed, John C ; Singer, Thomas ; Rothfuss, Andreas
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-11, Vol.12 (11), p.e0187574-e0187574
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Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies
Author / Creator:Hoffmann, Eugenia ; Jordan, Gregor ; Lauer, Matthias ; Ringler, Philippe ; Kusznir, Eric A. ; Rufer, Arne C. ; Huber, Sylwia ; Jochner, Anton ; Winter, Gerhard ; Staack, Roland F.
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2019-09, Vol.36 (9), p.129-15, Article 129
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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
Author / Creator:Cabrera, Alvaro Cortes ; Melo, Esther ; Roth, Doris ; Topp, Andreas ; Delobel, Frederic ; Stucki, Corinne ; Chen, Chia-yi ; Jakob, Peter ; Banfai, Balazs ; Dunkley, Tom ; Schilling, Oliver ; Huber, Sylwia ; Iacone, Roberto ; Petrone, Paula
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-11, Vol.7 (1), p.14804-11, Article 14804
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Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans
Author / Creator:Dangy, Jean-Pierre ; Scherr, Nicole ; Gersbach, Philipp ; Hug, Melanie N ; Bieri, Raphael ; Bomio, Claudio ; Li, Jun ; Huber, Sylwia ; Altmann, Karl-Heinz ; Pluschke, Gerd
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2016-06, Vol.10 (6), p.e0004808-e0004808
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies
Author / Creator:Moors, Tim E ; Mona, Daniel ; Luehe, Stefan ; Duran-Pacheco, Gonzalo ; Spycher, Liz ; Mundigl, Olaf ; Kaluza, Klaus ; Huber, Sylwia ; Hug, Melanie N ; Kremer, Thomas ; Ritter, Mirko ; Dziadek, Sebastian ; Dernick, Gregor ; van de Berg, Wilma D J ; Britschgi, Markus
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2022-06, Vol.10 (1), p.82-82, Article 82
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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling
Author / Creator:Moisan, Annie ; Gubler, Marcel ; Zhang, Jitao David ; Tessier, Yann ; Dumong Erichsen, Kamille ; Sewing, Sabine ; Gérard, Régine ; Avignon, Blandine ; Huber, Sylwia ; Benmansour, Fethallah ; Chen, Xing ; Villaseñor, Roberto ; Braendli-Baiocco, Annamaria ; Festag, Matthias ; Maunz, Andreas ; Singer, Thomas ; Schuler, Franz ; Roth, Adrian B.
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2017-03, Vol.6, p.89-105
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ArticlesPeer ReviewedFull Text
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy
Author / Creator:Moors, Tim E. ; Maat, Christina A. ; Niedieker, Daniel ; Mona, Daniel ; Petersen, Dennis ; Timmermans-Huisman, Evelien ; Kole, Jeroen ; El-Mashtoly, Samir F. ; Spycher, Liz ; Zago, Wagner ; Barbour, Robin ; Mundigl, Olaf ; Kaluza, Klaus ; Huber, Sylwia ; Hug, Melanie N. ; Kremer, Thomas ; Ritter, Mirko ; Dziadek, Sebastian ; Geurts, Jeroen J. G. ; Gerwert, Klaus ; Britschgi, Markus ; van de Berg, Wilma D. J.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2021-09, Vol.142 (3), p.423-448
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Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1
Author / Creator:Dawson, Roger J.P. ; Benz, Jörg ; Stohler, Peter ; Tetaz, Tim ; Joseph, Catherine ; Huber, Sylwia ; Schmid, Georg ; Hügin, Daniela ; Pflimlin, Pascal ; Trube, Gerd ; Rudolph, Markus G. ; Hennig, Michael ; Ruf, Armin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2012-07, Vol.3 (1), p.936-936, Article 936
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Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab
Author / Creator:Agez, Morgane ; Mandon, Elodie Desuzinges ; Iwema, Thomas ; Gianotti, Reto ; Limani, Florian ; Herter, Sylvia ; Mössner, Ekkehard ; Kusznir, Eric A. ; Huber, Sylwia ; Lauer, Matthias ; Ringler, Philippe ; Ferrara, Claudia ; Klein, Christian ; Jawhari, Anass
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-09, Vol.9 (1), p.13675-13, Article 13675
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ArticlesPeer ReviewedFull Text
Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1
Author / Creator:Conradi, Jens ; Huber, Sylwia ; Gaus, Katharina ; Mertink, Felix ; Royo Gracia, Soledad ; Strijowski, Ulf ; Backert, Steffen ; Sewald, Norbert
Publisher:Vienna: Springer Vienna
Journal title:Amino acids, 2012-07, Vol.43 (1), p.219-232
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Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ 5 -integrin–integrin linked kinase signalling complex
Author / Creator:Wiedemann, Tobias ; Hofbaur, Stefan ; Tegtmeyer, Nicole ; Huber, Sylwia ; Sewald, Norbert ; Wessler, Silja ; Backert, Steffen ; Rieder, Gabriele
Journal title:Gut, 2012-07, Vol.61 (7), p.986-996
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Helicobacter pylori CagL dependent induction of gastrin expression via a novel [alpha]v[beta]5-integrin-integrin linked kinase signalling complex
Author / Creator:Wiedemann, Tobias ; Hofbaur, Stefan ; Tegtmeyer, Nicole ; Huber, Sylwia ; Sewald, Norbert ; Wessler, Silja ; Backert, Steffen ; Rieder, Gabriele
Publisher:London: BMJ Publishing Group LTD
Journal title:Gut, 2012-07, Vol.61 (7), p.986
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ArticlesPeer ReviewedFull Text
Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin–integrin linked kinase signalling complex
Author / Creator:Wiedemann, Tobias ; Hofbaur, Stefan ; Tegtmeyer, Nicole ; Huber, Sylwia ; Sewald, Norbert ; Wessler, Silja ; Backert, Steffen ; Rieder, Gabriele
Publisher:London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2012-07, Vol.61 (7), p.986-996
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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins alpha sub(V) beta sub(3) and alpha sub(5) beta sub(1)
Author / Creator:Conradi, Jens ; Huber, Sylwia ; Gaus, Katharina ; Mertink, Felix ; Royo Gracia, Soledad ; Strijowski, Ulf ; Backert, Steffen ; Sewald, Norbert
Journal title:Amino acids, 2012-07, Vol.43 (1), p.219-232
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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins [alpha]^sub V^[beta]^sub 3^ and [alpha]^sub 5^[beta]^sub 1
Author / Creator:Conradi, Jens ; Huber, Sylwia ; Gaus, Katharina ; Mertink, Felix ; Royo Gracia, Soledad ; Strijowski, Ulf ; Backert, Steffen ; Sewald, Norbert
Publisher:Vienna: Springer Nature B.V
Journal title:Amino acids, 2012-07, Vol.43 (1), p.219
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ReportsFull Text
SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands
Author / Creator:Huber, Sylwia ; Casagrande, Fabio ; Hug, Melanie N ; Wang, Lisha ; Heine, Philipp ; Kummer, Lutz ; Plückthun, Andreas ; Hennig, Michael
Publisher:Public Library of Science
Journal title:PLoS ONE, 2017, Vol.12 (5), p.e0175842
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ArticlesFull Text
Subcellular orchestration of alpha-synuclein variants in Parkinson's disease brains as revealed by 3D multicolor STED microscopy
Author / Creator:Moors, Tim E ; Maat, Christina A ; Niedieker, Daniel ; Daniel, Mona ; Petersen, Dennis ; Timmermans-Huisman, Evelien ; Kole, Jeroen ; El-Mashtoly, Samir F ; Spycher, Liz ; Wagner Zago ; Barbour, Robin ; Mundigl, Olaf ; Kaluza, Klaus ; Huber, Sylwia ; Hug, Melanie N ; Kremer, Thomas ; Ritter, Mirko ; Dziadek, Sebastian ; Geurts, Jeroen Jg ; Gerwert, Klaus ; Britschgi, Markus ; Wilma Dj Van De Berg
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2019-09
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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

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Synthetic single domain antibodies for the conformational trapping of membrane proteins

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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia

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Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies

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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

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Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies

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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling

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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

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Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

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Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab

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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1

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Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ 5 -integrin–integrin linked kinase signalling complex

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Helicobacter pylori CagL dependent induction of gastrin expression via a novel [alpha]v[beta]5-integrin-integrin linked kinase signalling complex

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Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin–integrin linked kinase signalling complex

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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins alpha sub(V) beta sub(3) and alpha sub(5) beta sub(1)

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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins [alpha]^sub V^[beta]^sub 3^ and [alpha]^sub 5^[beta]^sub 1

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SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

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Subcellular orchestration of alpha-synuclein variants in Parkinson's disease brains as revealed by 3D multicolor STED microscopy

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