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407 results for Hydrazines+-+pharmacology

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ArticlesPeer ReviewedFull Text
Structural insights into the mechanism of human soluble guanylate cyclase
Author / Creator:Kang, Yunlu ; Liu, Rui ; Wu, Jing-Xiang ; Chen, Lei
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-10, Vol.574 (7777), p.206-210
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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
Author / Creator:Fiskus, W ; Sharma, S ; Shah, B ; Portier, B P ; Devaraj, S G T ; Liu, K ; Iyer, S P ; Bearss, D ; Bhalla, K N
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2014-11, Vol.28 (11), p.2155-2164
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ArticlesPeer ReviewedFull Text
Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth
Author / Creator:Buccarelli, Mariachiara ; D'Alessandris, Quintino Giorgio ; Matarrese, Paola ; Mollinari, Cristiana ; Signore, Michele ; Cappannini, Andrea ; Martini, Maurizio ; D'Aliberti, Pierluigi ; De Luca, Gabriele ; Pedini, Francesca ; Boe, Alessandra ; Biffoni, Mauro ; Pallini, Roberto ; Ricci-Vitiani, Lucia
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2021-07, Vol.40 (1), p.228-228, Article 228
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Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma
Author / Creator:Li, Yongyun ; Yang, Jie ; Zhang, Qianqian ; Xu, Shiqiong ; Sun, Wei ; Ge, Shengfang ; Xu, Xiaowei ; Jager, Martine J. ; Jia, Renbing ; Zhang, Jianming ; Fan, Xianqun
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2022-07, Vol.41 (27), p.3539-3553
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Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial
Author / Creator:Takayama, Koichi ; Katakami, Nobuyuki ; Yokoyama, Takuma ; Atagi, Shinji ; Yoshimori, Kozo ; Kagamu, Hiroshi ; Saito, Hiroshi ; Takiguchi, Yuichi ; Aoe, Keisuke ; Koyama, Akira ; Komura, Naoyuki ; Eguchi, Kenji
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Supportive care in cancer, 2016-08, Vol.24 (8), p.3495-3505
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The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review
Author / Creator:Landes, Jennifer R. ; Moore, Stephen A. ; Bartley, Brooke R. ; Doan, Hung Q. ; Rady, Peter L. ; Tyring, Stephen K.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Journal of cancer research and clinical oncology, 2023-05, Vol.149 (5), p.2139-2155
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ArticlesPeer ReviewedFull Text
Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
Author / Creator:Bello, Estefanía P ; Mateo, Yolanda ; Gelman, Diego M ; Noaín, Daniela ; Shin, Jung H ; Low, Malcolm J ; Alvarez, Verónica A ; Lovinger, David M ; Rubinstein, Marcelo
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2011-07, Vol.14 (8), p.1033-1038
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ArticlesPeer ReviewedFull Text
Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety
Author / Creator:Bingul, Murat ; Tan, Owen ; Gardner, Christopher R ; Sutton, Selina K ; Arndt, Greg M ; Marshall, Glenn M ; Cheung, Belamy B ; Kumar, Naresh ; Black, David StC
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2016-07, Vol.21 (7), p.916
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ArticlesPeer ReviewedFull Text
Eltrombopag directly inhibits BAX and prevents cell death
Author / Creator:Spitz, Adam Z. ; Zacharioudakis, Emmanouil ; Reyna, Denis E. ; Garner, Thomas P. ; Gavathiotis, Evripidis
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1134-15, Article 1134
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ArticlesPeer ReviewedFull Text
Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy
Author / Creator:Campbell, Grant R ; Spector, Stephen A
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2012-05, Vol.8 (5), p.e1002689-e1002689
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ArticlesPeer ReviewedFull Text
Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia
Author / Creator:Guan, Yihong ; Hasipek, Metis ; Jiang, Dongxu ; Tiwari, Anand D ; Grabowski, Dale R ; Pagliuca, Simona ; Kongkiatkamon, Sunisa ; Patel, Bhumika ; Singh, Salendra ; Parker, Yvonne ; LaFramboise, Thomas ; Lindner, Daniel ; Sekeres, Mikkael A ; Mian, Omar Y ; Saunthararajah, Yogen ; Maciejewski, Jaroslaw P ; Jha, Babal K
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-02, Vol.132 (4), p.1-13
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ArticlesPeer ReviewedFull Text
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia
Author / Creator:Gregory, Mark A. ; D’Alessandro, Angelo ; Alvarez-Calderon, Francesca ; Kim, Jihye ; Nemkov, Travis ; Adane, Biniam ; Rozhok, Andrii I. ; Kumar, Amit ; Kumar, Vijay ; Pollyea, Daniel A. ; Wempe, Michael F. ; Jordan, Craig T. ; Serkova, Natalie J. ; Choon Tan, Aik ; Hansen, Kirk C. ; DeGregori, James
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (43), p.E6669-E6678
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ArticlesPeer ReviewedFull Text
A selective Cu II complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells
Author / Creator:Machado, Pedro Henrique Alves ; Paixão, Drielly Aparecida ; Lino, Ricardo Campos ; de Souza, Tiago Rodrigues ; de Souza Bontempo, Nayara Júnia ; Sousa, Luana Munique ; Van Petten de Vasconcelos Azevedo, Fernanda ; Orsolin, Priscila Capelari ; Lima, Paula Marynella Alves Pereira ; Martins, Isabella Castro ; da Costa Guerra, Joyce Ferreira ; Teixeira, Samuel Cota ; Araújo, Thaise Gonçalves ; Goulart, Luiz Ricardo ; Morelli, Sandra ; Guerra, Wendell ; de Oliveira Júnior, Robson José
Publisher:England
Journal title:Scientific reports, 2021-12, Vol.11 (1), p.24450
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ArticlesPeer ReviewedFull Text
Ghrelin as a Promising Therapeutic Option for Cancer Cachexia
Author / Creator:Khatib, Mahalaqua Nazli ; Gaidhane, Abhay ; Gaidhane, Shilpa ; Quazi, Zahiruddin Syed
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Cellular physiology and biochemistry, 2018-01, Vol.48 (5), p.2172-2188
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ArticlesPeer ReviewedFull Text
Demographic toxicology of insect growth regulators on the nontarget ectolarval parasitoid Habrobracon hebetor
Author / Creator:Mansour, Amany N. ; Ghoneim, Karem S. ; Hamadah, Khaled S. ; Elsoud, Ahmed A. Abo
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-10, Vol.14 (1), p.26189-9, Article 26189
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ArticlesPeer ReviewedFull Text
Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing...
Author / Creator:Eldehna, Wagdy M ; Almahli, Hadia ; Al-Ansary, Ghada H ; Ghabbour, Hazem A ; Aly, Mohamed H ; Ismael, Omnia E ; Al-Dhfyan, Abdullah ; Abdel-Aziz, Hatem A
Publisher:Abingdon: Taylor & Francis Ltd
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.613
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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
Author / Creator:Etchin, J ; Montero, J ; Berezovskaya, A ; Le, B T ; Kentsis, A ; Christie, A L ; Conway, A S ; Chen, W C ; Reed, C ; Mansour, M R ; Ng, C E L ; Adamia, S ; Rodig, S J ; Galinsky, I A ; Stone, R M ; Klebanov, B ; Landesman, Y ; Kauffman, M ; Shacham, S ; Kung, A L ; Wang, J C Y ; Letai, A ; Look, A T
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2016-01, Vol.30 (1), p.0-0
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ArticlesPeer ReviewedFull Text
Methoxyfenozide tolerance in Chrysoperla carnea: Inheritance, dominance and preliminary detoxification mechanisms
Author / Creator:Mansoor, Muhammad Mudassir ; Shad, Sarfraz Ali
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-03, Vol.17 (3), p.e0265304-e0265304
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ArticlesPeer ReviewedFull Text
Base-line susceptibility of Tribolium castaneum to various synthetic insecticides
Author / Creator:Khizar, Mishal ; Hameed, Asifa ; Mohammed, Arif Ahmed ; Shad, Sarfaraz Ali ; Hussain, Mussurrat ; Abbas, Qaisar ; Shah, Tawaf Ali ; Attia, Kotb A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-02, Vol.15 (1), p.7097-7
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Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model
Author / Creator:Khan, Ashraf Ullah ; Khan, Amna ; Khan, Adnan ; Shal, Bushra ; Aziz, Abdul ; Ahmed, Muhammad Naeem ; Islam, Salman Ul ; Ali, Hussain ; Shehzad, Adeeb ; Khan, Salman
Publisher:Germany
Journal title:Naunyn-Schmiedeberg's archives of pharmacology, 2021-07, Vol.394 (7), p.1497
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Structural insights into the mechanism of human soluble guanylate cyclase

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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

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Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma

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Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial

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The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review

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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

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Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety

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Eltrombopag directly inhibits BAX and prevents cell death

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Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy

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Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia

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ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia

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A selective Cu II complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells

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Ghrelin as a Promising Therapeutic Option for Cancer Cachexia

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Demographic toxicology of insect growth regulators on the nontarget ectolarval parasitoid Habrobracon hebetor

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Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing...

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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice

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Methoxyfenozide tolerance in Chrysoperla carnea: Inheritance, dominance and preliminary detoxification mechanisms

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Base-line susceptibility of Tribolium castaneum to various synthetic insecticides

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Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model

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