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ArticlesPeer ReviewedFull Text
Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression
Author / Creator:Umemura, Shiori ; Sowa, Yoshihiro ; Iizumi, Yosuke ; Kitawaki, Jo ; Sakai, Toshiyuki
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2020-06, Vol.111 (6), p.2052-2061
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ArticlesPeer ReviewedFull Text
Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells
Author / Creator:Ichikawa, Masami ; Sowa, Yoshihiro ; Iizumi, Yosuke ; Aono, Yuichi ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-06, Vol.10 (6), p.e0129851-e0129851
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ArticlesPeer ReviewedFull Text
Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2
Author / Creator:Oishi, Masakatsu ; Iizumi, Yosuke ; Taniguchi, Tomoyuki ; Goi, Wakana ; Miki, Tsuneharu ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-02, Vol.8 (2), p.e55922
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ArticlesPeer ReviewedFull Text
The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9
Author / Creator:Iizumi, Yosuke ; Oishi, Masakatsu ; Taniguchi, Tomoyuki ; Goi, Wakana ; Sowa, Yoshihiro ; Sakai, Toshiyuki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-08, Vol.8 (8), p.e73219
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ArticlesPeer ReviewedFull Text
The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL
Author / Creator:SUN, QI ; YOGOSAWA, SHINGO ; IIZUMI, YOSUKE ; SAKAI, TOSHIYUKI ; SOWA, YOSHIHIRO
Publisher:Athens: D.A. Spandidos
Journal title:International journal of oncology, 2015-01, Vol.46 (1), p.389-394
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ArticlesPeer ReviewedFull Text
Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway
Author / Creator:Takakura, Hideki ; Nakao, Toshimasa ; Narita, Takumi ; Horinaka, Mano ; Nakao-Ise, Yukako ; Yamamoto, Tetsushi ; Iizumi, Yosuke ; Watanabe, Motoki ; Sowa, Yoshihiro ; Oda, Keisuke ; Mori, Nobuhiro ; Sakai, Toshiyuki ; Mutoh, Michihiro
Publisher:MDPI AG
Journal title:Biomedicines, 2022-06, Vol.10 (6), p.1352
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ArticlesFull Text
Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis
Author / Creator:Chihara, Yusuke ; Iizumi, Yosuke ; Horinaka, Mano ; Watanabe, Motoki ; Goi, Wakana ; Morita, Mie ; Nishimoto, Emi ; Sowa, Yoshihiro ; Yamada, Tadaaki ; Takayama, Koichi ; Sakai, Toshiyuki
Publisher:Athens: Spandidos Publications
Journal title:International journal of oncology, 2020-03, Vol.56 (3), p.848-856
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ArticlesPeer ReviewedFull Text
Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2
Author / Creator:Watanabe, Motoki ; Yamada, Yasumasa ; Kurumida, Yoichi ; Kameda, Tomoshi ; Sukeno, Mamiko ; Iizuka-Ohashi, Mahiro ; Sowa, Yoshihiro ; Iizumi, Yosuke ; Takakura, Hideki ; Miyamoto, Shingo ; Sakai, Toshiyuki ; Mutoh, Michihiro
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2021-02, Vol.13 (5), p.982
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ArticlesPeer ReviewedFull Text
Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol
Author / Creator:Iizumi, Yosuke ; Sowa, Yoshihiro ; Goi, Wakana ; Aono, Yuichi ; Watanabe, Motoki ; Kurumida, Yoichi ; Kameda, Tomoshi ; Akaji, Kenichi ; Kitagawa, Masatoshi ; Sakai, Toshiyuki
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2022-06, Vol.5 (1), p.564-564, Article 564
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ArticlesPeer ReviewedFull Text
Perillyl alcohol causes G1 arrest through p15INK4b and p21WAF1/Cip1 induction
Author / Creator:KOYAMA, MAKOTO ; SOWA, YOSHIHIRO ; HITOMI, TOSHIAKI ; IIZUMI, YOSUKE ; WATANABE, MOTOKI ; TANIGUCHI, TOMOYUKI ; ICHIKAWA, MASAMI ; SAKAI, TOSHIYUKI
Publisher:Athens: D.A. Spandidos
Journal title:Oncology reports, 2013-02, Vol.29 (2), p.779-784
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ArticlesPeer ReviewedFull Text
Ribosomal protein S3 regulates XIAP expression independently of the NF-κB pathway in breast cancer cells
Author / Creator:Ono, Hisako ; Iizumi, Yosuke ; Goi, Wakana ; Sowa, Yoshihiro ; Taguchi, Tetsuya ; Sakai, Toshiyuki
Publisher:Greece: D.A. Spandidos
Journal title:Oncology reports, 2017-11, Vol.38 (5), p.3205-3210
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ArticlesPeer ReviewedFull Text
The histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth of triple-negative breast cancer cells with the suppression of survivin, Bcl-xL, and the MAPK pathway
Author / Creator:Ono, Hisako ; Sowa, Yoshihiro ; Horinaka, Mano ; Iizumi, Yosuke ; Watanabe, Motoki ; Morita, Mie ; Nishimoto, Emi ; Taguchi, Tetsuya ; Sakai, Toshiyuki
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2018-08, Vol.171 (1), p.43-52
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ArticlesFull Text
Ribosomal protein S3 regulates XIAP expression independently of the NF-[kappa]B pathway in breast cancer cells
Author / Creator:Ono, Hisako ; Iizumi, Yosuke ; Goi, Wakana ; Sowa, Yoshihiro ; Taguchi, Tetsuya ; Sakai, Toshiyuki
Publisher:Spandidos Publications
Journal title:Oncology reports, 2017-11, Vol.38 (5), p.3205
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ArticlesFull Text
Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction
Author / Creator:Koyama, Makoto ; Sowa, Yoshihiro ; Hitomi, Toshiaki ; Iizumi, Yosuke ; Watanabe, Motoki ; Taniguchi, Tomoyuki ; Ichikawa, Masami ; Sakai, Toshiyuki
Publisher:Greece
Journal title:Oncology reports, 2013-02, Vol.29 (2), p.779-784
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ArticlesPeer ReviewedFull Text
A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5
Author / Creator:Watanabe, Motoki ; Boku, Shogen ; Kobayashi, Kaito ; Kurumida, Yoichi ; Sukeno, Mamiko ; Masuda, Mitsuharu ; Mizushima, Katsura ; Kato, Chikage ; Iizumi, Yosuke ; Hirota, Kiichi ; Naito, Yuji ; Mutoh, Michihiro ; Kameda, Tomoshi ; Sakai, Toshiyuki
Publisher:England: Oxford University Press
Journal title:PNAS nexus, 2022-05, Vol.1 (2), p.pgac059-pgac059
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ArticlesPeer ReviewedFull Text
ICitrus limon/IIL/I.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway
Author / Creator:Takakura, Hideki ; Nakao, Toshimasa ; Narita, Takumi ; Horinaka, Mano ; Nakao-Ise, Yukako ; Yamamoto, Tetsushi ; Iizumi, Yosuke ; Watanabe, Motoki ; Sowa, Yoshihiro ; Oda, Keisuke ; Mori, Nobuhiro ; Sakai, Toshiyuki ; Mutoh, Michihiro
Publisher:MDPI AG
Journal title:Biomedicines, 2022-06, Vol.10 (6)
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ArticlesPeer ReviewedFull Text
Citrus limonL.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway
Author / Creator:Takakura, Hideki ; Nakao, Toshimasa ; Narita, Takumi ; Horinaka, Mano ; Nakao-Ise, Yukako ; Yamamoto, Tetsushi ; Iizumi, Yosuke ; Watanabe, Motoki ; Sowa, Yoshihiro ; Oda, Keisuke ; Mori, Nobuhiro ; Sakai, Toshiyuki ; Mutoh, Michihiro
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2022-06, Vol.10 (6), p.1352
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Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression

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Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells

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Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2

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The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9

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The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL

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Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway

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Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis

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Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2

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Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

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Perillyl alcohol causes G1 arrest through p15INK4b and p21WAF1/Cip1 induction

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Ribosomal protein S3 regulates XIAP expression independently of the NF-κB pathway in breast cancer cells

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The histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth of triple-negative breast cancer cells with the suppression of survivin, Bcl-xL, and the MAPK pathway

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Ribosomal protein S3 regulates XIAP expression independently of the NF-[kappa]B pathway in breast cancer cells

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Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction

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A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5

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ICitrus limon/IIL/I.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway

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Citrus limonL.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway

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