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ArticlesPeer ReviewedFull Text
Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo
Author / Creator:Ranganath, Sheila ; Bhandari, Ashok ; Avitahl-Curtis, Nicole ; McMahon, Jaimee ; Wachtel, Derek ; Zhang, Jenny ; Leitheiser, Christopher ; Bernier, Sylvie G ; Liu, Guang ; Tran, Tran T ; Celino, Herodion ; Tobin, Jenny ; Jung, Joon ; Zhao, Hong ; Glen, Katie E ; Graul, Chris ; Griffin, Aliesha ; Schairer, Wayne C ; Higgins, Carolyn ; Reza, Tammi L ; Mowe, Eva ; Rivers, Sam ; Scott, Sonya ; Monreal, Alex ; Shea, Courtney ; Bourne, Greg ; Coons, Casey ; Smith, Adaline ; Tang, Kim ; Mandyam, Ramya A ; Masferrer, Jaime ; Liu, David ; Patel, Dinesh V ; Fretzen, Angelika ; Murphy, Craig A ; Milne, G Todd ; Smythe, Mark L ; Carlson, Kenneth E
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-11, Vol.10 (11), p.e0141330-e0141330
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Biological characteristics of IL-6 and related intestinal diseases
Author / Creator:Guo, Yuexin ; Wang, Boya ; Wang, Tiantian ; Gao, Lei ; Yang, Ze-Jun ; Wang, Fei-Fei ; Shang, Hong-Wei ; Hua, Rongxuan ; Xu, Jing-Dong
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:International journal of biological sciences, 2021-01, Vol.17 (1), p.204-219
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Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
Author / Creator:Boulanger, Martin J. ; Chow, Dar-Chone ; Brevnova, Elena E. ; Garcia, K. Christopher
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2003-06, Vol.300 (5628), p.2101-2104
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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation
Author / Creator:Riethmueller, Steffen ; Somasundaram, Prasath ; Ehlers, Johanna C ; Hung, Chien-Wen ; Flynn, Charlotte M ; Lokau, Juliane ; Agthe, Maria ; Düsterhöft, Stefan ; Zhu, Yijue ; Grötzinger, Joachim ; Lorenzen, Inken ; Koudelka, Tomas ; Yamamoto, Kosuke ; Pickhinke, Ute ; Wichert, Rielana ; Becker-Pauly, Christoph ; Rädisch, Marisa ; Albrecht, Alexander ; Hessefort, Markus ; Stahnke, Dominik ; Unverzagt, Carlo ; Rose-John, Stefan ; Tholey, Andreas ; Garbers, Christoph
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-01, Vol.15 (1), p.e2000080-e2000080
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ArticlesPeer ReviewedFull Text
TNFα, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each other and at different stages of the disease
Author / Creator:Costantini, Erica ; Sinjari, Bruna ; Di Giovanni, Pamela ; Aielli, Lisa ; Caputi, Sergio ; Muraro, Raffaella ; Murmura, Giovanna ; Reale, Marcella
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-01, Vol.13 (1), p.126-10, Article 126
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Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis
Author / Creator:Li, Kaitong ; Cai, Junyu ; Jiang, Zhiyang ; Meng, Qingbin ; Meng, Zhao ; Xiao, He ; Chen, Guojiang ; Qiao, Chunxia ; Luo, Longlong ; Yu, Jijun ; Li, Xinying ; Wei, Yinxiang ; Li, Hui ; Liu, Chenghua ; Shen, Beifen ; Wang, Jing ; Feng, Jiannan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-08, Vol.14 (1), p.18293-14, Article 18293
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The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes
Author / Creator:Matsuo, Reo ; Morihara, Hirofumi ; Mohri, Tomomi ; Murasawa, Shiho ; Takewaki, Kana ; Nakayama, Hiroyuki ; Maeda, Makiko ; Fujio, Yasushi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-10, Vol.9 (10), p.e111097
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Side chain determinants of biopolymer function during selection and replication
Author / Creator:Lichtor, Phillip A. ; Chen, Zhen ; Elowe, Nadine H. ; Chen, Jonathan C. ; Liu, David R.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2019-04, Vol.15 (4), p.419-426
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Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
Author / Creator:Skiniotis, Georgios ; Boulanger, Martin J ; Garcia, K Christopher ; Walz, Thomas
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2005-06, Vol.12 (6), p.545-551
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ArticlesPeer ReviewedFull Text
IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network
Author / Creator:Cao, Ruifen ; Li, Qiangsheng ; Wei, Pijing ; Ding, Yun ; Bin, Yannan ; Zheng, Chunhou
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2025-01, Vol.15 (1), p.99
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Mechanism of XiJiaQi in the treatment of chronic heart failure: Integrated analysis by pharmacoinformatics, molecular dynamics simulation, and SPR validation
Author / Creator:Zhao, Dongyang ; Guo, Kaijing ; Zhang, Qian ; Wu, Yan ; Ma, Chen ; He, Wenyi ; Jin, Xiangju ; Zhang, Xinyu ; Wang, Yanan ; Lin, Sheng ; Shang, Hongcai
Publisher:United States: Elsevier Ltd
Journal title:Computers in biology and medicine, 2023-11, Vol.166, p.107479-107479, Article 107479
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Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
Author / Creator:Al-Rasheed, Nouf M ; Al-Rasheed, Nawal M ; Hasan, Iman H ; Al-Amin, Maha A ; Al-Ajmi, Hanaa N ; Mahmoud, Ayman M
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2016-01, Vol.10, p.2095-2107
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Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Author / Creator:Martinez-Fabregas, Jonathan ; Wilmes, Stephan ; Wang, Luopin ; Hafer, Maximillian ; Pohler, Elizabeth ; Lokau, Juliane ; Garbers, Christoph ; Cozzani, Adeline ; Fyfe, Paul K ; Piehler, Jacob ; Kazemian, Majid ; Mitra, Suman ; Moraga, Ignacio
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-11, Vol.8
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Relation between amniotic fluid infection or cytokine levels and hearing screen failure in infants at 32 wk gestation or less
Author / Creator:Jung, Eun Young ; Choi, Byung Yoon ; Rhee, Jihye ; Park, Jaehong ; Cho, Soo-Hyun ; Park, Kyo Hoon
Publisher:New York: Nature Publishing Group US
Journal title:Pediatric research, 2017-02, Vol.81 (2), p.349-355
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Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1
Author / Creator:Yi, Erkang ; Zhang, Jiahuan ; Zheng, Mengning ; Zhang, Yi ; Liang, Chunxiao ; Hao, Binwei ; Hong, Wei ; Lin, Biting ; Pu, Jinding ; Lin, Zhiwei ; Huang, Peiyu ; Li, Bing ; Zhou, Yumin ; Ran, Pixin
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational medicine, 2021-07, Vol.11 (7), p.e479-n/a
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Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily
Author / Creator:Jones, Lindsay L. ; Vignali, Dario A. A.
Publisher:New York: Humana Press Inc
Journal title:Immunologic research, 2011-10, Vol.51 (1), p.5-14
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Interleukin-6 and its receptor : from bench to bedside
Author / Creator:SCHELLER, Jürgen ; ROSE-JOHN, Stefan
Publisher:Berlin: Springer
Journal title:Medical microbiology and immunology, 2006-12, Vol.195 (4), p.173-183
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The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability
Author / Creator:Boink, Mireille A ; Roffel, Sanne ; Nazmi, Kamran ; van Montfrans, Catherine ; Bolscher, Jan G M ; Gefen, Amit ; Veerman, Enno C I ; Gibbs, Susan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-03, Vol.11 (3), p.e0152613-e0152613
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Inflammatory illness: Why the next wave of antidepressants may target the immune system
Author / Creator:Wetsman, Nicole
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-09, Vol.23 (9), p.1009-1011
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The Blockade of IL-6 Signaling in Rational Drug Design
Author / Creator:Adachi, Yasuo ; Yoshio-Hoshino, Naoko ; Nishimoto, Norihiro
Publisher:Hilversum: Bentham Science Publishers Ltd
Journal title:Current pharmaceutical design, 2008-04, Vol.14 (12), p.1217-1224
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

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Biological characteristics of IL-6 and related intestinal diseases

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Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

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TNFα, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each other and at different stages of the disease

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Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

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The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes

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Side chain determinants of biopolymer function during selection and replication

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Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor

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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network

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Mechanism of XiJiaQi in the treatment of chronic heart failure: Integrated analysis by pharmacoinformatics, molecular dynamics simulation, and SPR validation

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Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

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Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

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Relation between amniotic fluid infection or cytokine levels and hearing screen failure in infants at 32 wk gestation or less

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Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1

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Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily

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Interleukin-6 and its receptor : from bench to bedside

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The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability

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Inflammatory illness: Why the next wave of antidepressants may target the immune system

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The Blockade of IL-6 Signaling in Rational Drug Design

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