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Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents
Author / Creator:Altamimi, Mohammad ; Syed, Saeed Ali ; Tuzun, Burak ; Alhazani, Mohammad Rashid ; Alnemer, Osamah ; Bari, Ahmed
Publisher:England: Taylor & Francis Ltd
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2024-12, Vol.39 (1), p.2288548
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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
Author / Creator:Panda, Siva S. ; Girgis, Adel S. ; Aziz, Marian N. ; Bekheit, Mohamed S.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.618
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Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
Author / Creator:Abdelrahman, Mohamed A. ; Almahli, Hadia ; Al-Warhi, Tarfah ; Majrashi, Taghreed A. ; Abdel-Aziz, Marwa M. ; Eldehna, Wagdy M. ; Said, Mohamed A.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-12, Vol.27 (24), p.8807
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Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect
Author / Creator:Kumar, Sunil ; Oh, Jong Min ; Prabhakaran, Prabitha ; Awasti, Abhimanyu ; Kim, Hoon ; Mathew, Bijo
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-01, Vol.14 (1), p.1264-20, Article 1264
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Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Author / Creator:Shaldam, Moataz A. ; Almahli, Hadia ; Angeli, Andrea ; Badi, Rehab Mustafa ; Khaleel, Eman F. ; Zain-Alabdeen, Abdelrahman I. ; Elsayed, Zainab M. ; Elkaeed, Eslam B. ; Salem, Rofaida ; Supuran, Claudiu T. ; Eldehna, Wagdy M. ; Tawfik, Haytham O.
Publisher:England: Taylor & Francis
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2203389
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Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives
Author / Creator:Arshad, Nasima ; Mir, Muhammad Ismail ; Perveen, Fouzia ; Javed, Aneela ; Javaid, Memona ; Saeed, Aamer ; Channar, Pervaiz Ali ; Farooqi, Shahid Iqbal ; Alkahtani, Saad ; Anwar, Jamshed
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-01, Vol.27 (2), p.354
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Evaluation of N -alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
Author / Creator:Alcorn, Kaitlyn N. ; Oberhauser, Isabelle A. ; Politeski, Matthew D. ; Eckroat, Todd J.
Publisher:England: Taylor & Francis Ltd
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2024-12, Vol.39 (1), p.2286935
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One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer
Author / Creator:Glaser, Matthias ; Rajkumar, Vineeth ; Diocou, Seckou ; Gendron, Thibault ; Yan, Ran ; Sin, Pak Kwan Brian ; Sander, Kerstin ; Carroll, Laurence ; Pedley, R. Barbara ; Aboagye, Eric O. ; Witney, Timothy H. ; Årstad, Erik
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-12, Vol.9 (1), p.19299-8, Article 19299
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Phosphorus-Derived Isatin Hydrazones: Synthesis, Structure, Thromboelastography, Antiplatelet, and Anticoagulation Activity Evaluation
Author / Creator:Samorodov, Aleksandr V. ; Yi, Wang ; Kudlay, Dmitry A. ; Smolyarchuk, Elena A. ; Dobrynin, Alexey B. ; Khamatgalimov, Ayrat R. ; Shchebneva, Karina ; Kadomtseva, Marina ; Komunarova, Dilbar ; Strelnik, Anna G. ; Bogdanov, Andrei V.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-07, Vol.26 (13), p.6147
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A novel isatin Schiff based cerium complex: synthesis, characterization, antimicrobial activity and molecular docking studies
Author / Creator:Saad, Heba E. ; El-Reash, Gaber M. Abu ; gaber, Mohamed ; Hashem, Mohamed A. ; El-Reash, Yasmeen G. Abou ; Elamin, Nuha Y. ; Elamin, Mohamed R. ; El-Sayed, Yusif S.
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2024-02, Vol.25 (1), p.162-10, Article 162
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Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents
Author / Creator:Singh, Atamjit ; Singh, Karanvir ; Sharma, Aman ; Sharma, Sambhav ; Batra, Kevin ; Joshi, Kaustubh ; Singh, Brahmjeet ; Kaur, Kirandeep ; Chadha, Renu ; Bedi, Preet Mohinder Singh
Publisher:New York: Springer US
Journal title:Molecular and cellular biochemistry, 2024-05, Vol.479 (5), p.1165-1198
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A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor
Author / Creator:Al-Salem, Huda S. ; Arifuzzaman, Md ; Alkahtani, Hamad M. ; Abdalla, Ashraf N. ; Issa, Iman S. ; Alqathama, Aljawharah ; Albalawi, Fatemah S. ; Rahman, A. F. M. Motiur
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-09, Vol.25 (19), p.4400
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Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing...
Author / Creator:Eldehna, Wagdy M ; Almahli, Hadia ; Al-Ansary, Ghada H ; Ghabbour, Hazem A ; Aly, Mohamed H ; Ismael, Omnia E ; Al-Dhfyan, Abdullah ; Abdel-Aziz, Hatem A
Publisher:Abingdon: Taylor & Francis Ltd
Journal title:Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.613
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Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors
Author / Creator:Dimkovski, Aleksandar ; Dobričić, Vladimir ; Simić, Milena R. ; Jurhar Pavlova, Maja ; Mihajloska, Evgenija ; Sterjev, Zoran ; Poceva Panovska, Ana
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-05, Vol.30 (10), p.2121
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Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation
Author / Creator:Alanazi, Mohammed M. ; Alanazi, Ashwag S.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-08, Vol.28 (15), p.5869
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Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation
Author / Creator:Wang, Rongrong ; Zhang, Zhili ; Jiang, Wei ; Liu, Junyi ; Tian, Chao ; Wang, Meng
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-03, Vol.30 (7), p.1421
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Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor
Author / Creator:Gowda, Krishne ; Raza, Asif ; Vangala, Venugopal ; Lone, Nazir Ahmad ; Lin, Jyh Ming ; Singh, Jaikee Kumar ; Srivastava, Sandeep Kumar ; Schell, Todd D. ; Robertson, Gavin P. ; Amin, Shantu ; Sharma, Arun K.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-06, Vol.29 (13), p.3114
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Design and Synthesis of New 5-Methylisatin Derivatives as Potential CDK2 Inhibitors
Author / Creator:Czeleń, Przemysław ; Skotnicka, Agnieszka ; Szefler, Beata ; Kabatc-Borcz, Janina ; Sutkowy, Paweł
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-02, Vol.26 (5), p.2144
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Synthesis and Docking Studies of Novel Spiro[5,8-methanoquinazoline-2,3′-indoline]-2′,4-dione Derivatives
Author / Creator:Faragó, Tünde ; Mészáros, Rebeka ; Wéber, Edit ; Palkó, Márta
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-11, Vol.29 (21), p.5112
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Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity
Author / Creator:Uvarov, Alexander V. ; Schepetkin, Igor A. ; Quinn, Mark T. ; Khlebnikov, Andrei I.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-07, Vol.30 (14), p.2914
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Showing 1 to 20 of 71 results

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Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents

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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

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Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

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Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect

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Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

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Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives

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Evaluation of N -alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors

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One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer

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Phosphorus-Derived Isatin Hydrazones: Synthesis, Structure, Thromboelastography, Antiplatelet, and Anticoagulation Activity Evaluation

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A novel isatin Schiff based cerium complex: synthesis, characterization, antimicrobial activity and molecular docking studies

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Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents

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A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor

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Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing...

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Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors

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Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation

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Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation

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Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor

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Design and Synthesis of New 5-Methylisatin Derivatives as Potential CDK2 Inhibitors

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Synthesis and Docking Studies of Novel Spiro[5,8-methanoquinazoline-2,3′-indoline]-2′,4-dione Derivatives

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Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity

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