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156 results for Joung,+J.+Keith

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ArticlesPeer ReviewedFull Text
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
Author / Creator:Kurt, Ibrahim C. ; Zhou, Ronghao ; Iyer, Sowmya ; Garcia, Sara P. ; Miller, Bret R. ; Langner, Lukas M. ; Grünewald, Julian ; Joung, J. Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2021-01, Vol.39 (1), p.41-46
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ArticlesPeer ReviewedFull Text
Gene therapy comes of age
Author / Creator:Dunbar, Cynthia E. ; High, Katherine A. ; Joung, J. Keith ; Kohn, Donald B. ; Ozawa, Keiya ; Sadelain, Michel
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-01, Vol.359 (6372)
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Newsletter articlesFull Text
INTERNATIONAL PATENT: JOUNG, J. KEITH , ZHOU, RONGHAO , GRUNEWALD, JULIAN FILES APPLICATION FOR "COMBINATORIAL ADENINE AND CYTOSINE DNA BASE EDITORS"
Publisher:Washington, D.C: HT Digital Streams Limited
Journal title:US Fed News Service, Including US State News, 2021
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ArticlesPeer ReviewedFull Text
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
Author / Creator:Hsu, Jonathan Y. ; Grünewald, Julian ; Szalay, Regan ; Shih, Justine ; Anzalone, Andrew V. ; Lam, Kin Chung ; Shen, Max W. ; Petri, Karl ; Liu, David R. ; Joung, J. Keith ; Pinello, Luca
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1034-6, Article 1034
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ArticlesPeer ReviewedFull Text
CRISPResso2 provides accurate and rapid genome editing sequence analysis
Author / Creator:Clement, Kendell ; Rees, Holly ; Canver, Matthew C. ; Gehrke, Jason M. ; Farouni, Rick ; Hsu, Jonathan Y. ; Cole, Mitchel A. ; Liu, David R. ; Joung, J. Keith ; Bauer, Daniel E. ; Pinello, Luca
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2019-03, Vol.37 (3), p.224-226
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ArticlesPeer ReviewedFull Text
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Author / Creator:Fu, Yanfang ; Sander, Jeffry D ; Reyon, Deepak ; Cascio, Vincent M ; Joung, J Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2014-03, Vol.32 (3), p.279-284
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ArticlesPeer ReviewedFull Text
Therapeutic base editing of human hematopoietic stem cells
Author / Creator:Zeng, Jing ; Wu, Yuxuan ; Ren, Chunyan ; Bonanno, Jasmine ; Shen, Anne H. ; Shea, Devlin ; Gehrke, Jason M. ; Clement, Kendell ; Luk, Kevin ; Yao, Qiuming ; Kim, Rachel ; Wolfe, Scot A. ; Manis, John P. ; Pinello, Luca ; Joung, J. Keith ; Bauer, Daniel E.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-04, Vol.26 (4), p.535-541
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ArticlesPeer ReviewedFull Text
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
Author / Creator:Grünewald, Julian ; Zhou, Ronghao ; Garcia, Sara P. ; Iyer, Sowmya ; Lareau, Caleb A. ; Aryee, Martin J. ; Joung, J. Keith
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-05, Vol.569 (7756), p.433-437
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ArticlesPeer ReviewedFull Text
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
Author / Creator:Kleinstiver, Benjamin P ; Tsai, Shengdar Q ; Prew, Michelle S ; Nguyen, Nhu T ; Welch, Moira M ; Lopez, Jose M ; McCaw, Zachary R ; Aryee, Martin J ; Joung, J Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2016-08, Vol.34 (8), p.869-874
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ArticlesPeer ReviewedFull Text
Zinc-finger Nucleases: The Next Generation Emerges
Author / Creator:Cathomen, Toni ; Keith Joung, J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2008-07, Vol.16 (7), p.1200-1207
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ArticlesPeer ReviewedFull Text
Discovery of widespread type I and type V CRISPR-Cas inhibitors
Author / Creator:Marino, Nicole D. ; Zhang, Jenny Y. ; Borges, Adair L. ; Sousa, Alexander A. ; Leon, Lina M. ; Rauch, Benjamin J. ; Walton, Russell T. ; Berry, Joel D. ; Joung, J. Keith ; Kleinstiver, Benjamin P. ; Bondy-Denomy, Joseph
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-10, Vol.362 (6411), p.240-242
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ArticlesPeer ReviewedFull Text
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Author / Creator:Fu, Yanfang ; Foden, Jennifer A ; Khayter, Cyd ; Maeder, Morgan L ; Reyon, Deepak ; Joung, J Keith ; Sander, Jeffry D
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2013-09, Vol.31 (9), p.822-826
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ArticlesPeer ReviewedFull Text
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
Author / Creator:Chen, Janice S. ; Dagdas, Yavuz S. ; Kleinstiver, Benjamin P. ; Welch, Moira M. ; Sousa, Alexander A. ; Harrington, Lucas B. ; Sternberg, Samuel H. ; Joung, J. Keith ; Yildiz, Ahmet ; Doudna, Jennifer A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-10, Vol.550 (7676), p.407-410
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ArticlesPeer ReviewedFull Text
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Author / Creator:Kleinstiver, Benjamin P ; Prew, Michelle S ; Tsai, Shengdar Q ; Nguyen, Nhu T ; Topkar, Ved V ; Zheng, Zongli ; Joung, J Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2015-12, Vol.33 (12), p.1293-1298
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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
Author / Creator:Tsai, Shengdar Q ; Wyvekens, Nicolas ; Khayter, Cyd ; Foden, Jennifer A ; Thapar, Vishal ; Reyon, Deepak ; Goodwin, Mathew J ; Aryee, Martin J ; Joung, J Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2014-06, Vol.32 (6), p.569-576
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ArticlesPeer ReviewedFull Text
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
Author / Creator:Kleinstiver, Benjamin P. ; Sousa, Alexander A. ; Walton, Russell T. ; Tak, Y. Esther ; Hsu, Jonathan Y. ; Clement, Kendell ; Welch, Moira M. ; Horng, Joy E. ; Malagon-Lopez, Jose ; Scarfò, Irene ; Maus, Marcela V. ; Pinello, Luca ; Aryee, Martin J. ; Joung, J. Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2019-03, Vol.37 (3), p.276-282
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ArticlesPeer ReviewedFull Text
CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells
Author / Creator:Petri, Karl ; Zhang, Weiting ; Ma, Junyan ; Schmidts, Andrea ; Lee, Hyunho ; Horng, Joy E. ; Kim, Daniel Y. ; Kurt, Ibrahim C. ; Clement, Kendell ; Hsu, Jonathan Y. ; Pinello, Luca ; Maus, Marcela V. ; Joung, J. Keith ; Yeh, Jing-Ruey Joanna
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2022-02, Vol.40 (2), p.189-193
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ArticlesPeer ReviewedFull Text
Adopt a moratorium on heritable genome editing
Author / Creator:Lander, Eric S. ; Baylis, Françoise ; Zhang, Feng ; Charpentier, Emmanuelle ; Berg, Paul ; Bourgain, Catherine ; Friedrich, Bärbel ; Joung, J. Keith ; Li, Jinsong ; Liu, David ; Naldini, Luigi ; Nie, Jing-Bao ; Qiu, Renzong ; Schoene-Seifert, Bettina ; Shao, Feng ; Terry, Sharon ; Wei, Wensheng ; Winnacker, Ernst-Ludwig
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-03, Vol.567 (7747), p.165-168
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Optimization of AsCas12a for combinatorial genetic screens in human cells
Author / Creator:DeWeirdt, Peter C. ; Sanson, Kendall R. ; Sangree, Annabel K. ; Hegde, Mudra ; Hanna, Ruth E. ; Feeley, Marissa N. ; Griffith, Audrey L. ; Teng, Teng ; Borys, Samantha M. ; Strand, Christine ; Joung, J. Keith ; Kleinstiver, Benjamin P. ; Pan, Xuewen ; Huang, Alan ; Doench, John G.
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2021-01, Vol.39 (1), p.94-104
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ArticlesPeer ReviewedFull Text
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Author / Creator:Tsai, Shengdar Q ; Zheng, Zongli ; Nguyen, Nhu T ; Liebers, Matthew ; Topkar, Ved V ; Thapar, Vishal ; Wyvekens, Nicolas ; Khayter, Cyd ; Iafrate, A John ; Le, Long P ; Aryee, Martin J ; Joung, J Keith
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2015-02, Vol.33 (2), p.187-197
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Showing 1 to 20 of 156 results

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CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

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Gene therapy comes of age

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INTERNATIONAL PATENT: JOUNG, J. KEITH , ZHOU, RONGHAO , GRUNEWALD, JULIAN FILES APPLICATION FOR "COMBINATORIAL ADENINE AND CYTOSINE DNA BASE EDITORS"

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PrimeDesign software for rapid and simplified design of prime editing guide RNAs

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CRISPResso2 provides accurate and rapid genome editing sequence analysis

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

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Therapeutic base editing of human hematopoietic stem cells

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Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

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Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

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Zinc-finger Nucleases: The Next Generation Emerges

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Discovery of widespread type I and type V CRISPR-Cas inhibitors

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

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Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

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CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

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Adopt a moratorium on heritable genome editing

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Optimization of AsCas12a for combinatorial genetic screens in human cells

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

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