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15 results for Kadel,+Edward+E

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ArticlesPeer ReviewedFull Text
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Author / Creator:Mariathasan, Sanjeev ; Turley, Shannon J. ; Nickles, Dorothee ; Castiglioni, Alessandra ; Yuen, Kobe ; Wang, Yulei ; Kadel III, Edward E. ; Koeppen, Hartmut ; Astarita, Jillian L. ; Cubas, Rafael ; Jhunjhunwala, Suchit ; Banchereau, Romain ; Yang, Yagai ; Guan, Yinghui ; Chalouni, Cecile ; Ziai, James ; Şenbabaoğlu, Yasin ; Santoro, Stephen ; Sheinson, Daniel ; Hung, Jeffrey ; Giltnane, Jennifer M. ; Pierce, Andrew A. ; Mesh, Kathryn ; Lianoglou, Steve ; Riegler, Johannes ; Carano, Richard A. D. ; Eriksson, Pontus ; Höglund, Mattias ; Somarriba, Loan ; Halligan, Daniel L. ; van der Heijden, Michiel S. ; Loriot, Yohann ; Rosenberg, Jonathan E. ; Fong, Lawrence ; Mellman, Ira ; Chen, Daniel S. ; Green, Marjorie ; Derleth, Christina ; Fine, Gregg D. ; Hegde, Priti S. ; Bourgon, Richard ; Powles, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-02, Vol.554 (7693), p.544-548
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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Author / Creator:Yuen, Kobe C. ; Liu, Li-Fen ; Gupta, Vinita ; Madireddi, Shravan ; Keerthivasan, Shilpa ; Li, Congfen ; Rishipathak, Deepali ; Williams, Patrick ; Kadel, Edward E. ; Koeppen, Hartmut ; Chen, Ying-Jiun ; Modrusan, Zora ; Grogan, Jane L. ; Banchereau, Romain ; Leng, Ning ; Thastrom, AnnChristine ; Shen, Xiadong ; Hashimoto, Kenji ; Tayama, Darren ; van der Heijden, Michiel S. ; Rosenberg, Jonathan E. ; McDermott, David F. ; Powles, Thomas ; Hegde, Priti S. ; Huseni, Mahrukh A. ; Mariathasan, Sanjeev
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-05, Vol.26 (5), p.693-698
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Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial
Author / Creator:Balar, Arjun V, Dr ; Galsky, Matthew D, MD ; Rosenberg, Jonathan E, MD ; Powles, Thomas, MD ; Petrylak, Daniel P, MD ; Bellmunt, Joaquim, MD ; Loriot, Yohann, MD ; Necchi, Andrea, MD ; Hoffman-Censits, Jean, MD ; Perez-Gracia, Jose Luis, MD ; Dawson, Nancy A, MD ; van der Heijden, Michiel S, MD ; Dreicer, Robert, MD ; Srinivas, Sandy, MD ; Retz, Margitta M, MD ; Joseph, Richard W, MD ; Drakaki, Alexandra, MD ; Vaishampayan, Ulka N, MD ; Sridhar, Srikala S, MD ; Quinn, David I, MD ; Durán, Ignacio, MD ; Shaffer, David R, MD ; Eigl, Bernhard J, MD ; Grivas, Petros D, MD ; Yu, Evan Y, MD ; Li, Shi, PhD ; Kadel, Edward E, BS ; Boyd, Zachary, MSc ; Bourgon, Richard, PhD ; Hegde, Priti S, PhD ; Mariathasan, Sanjeev, PhD ; Thåström, AnnChristine, PhD ; Abidoye, Oyewale O, MD ; Fine, Gregg D, MD ; Bajorin, Dean F, MD
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2017-01, Vol.389 (10064), p.67-76
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Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial
Author / Creator:Powles, Thomas ; Durán, Ignacio ; van der Heijden, Michiel S ; Loriot, Yohann ; Vogelzang, Nicholas J ; De Giorgi, Ugo ; Oudard, Stéphane ; Retz, Margitta M ; Castellano, Daniel ; Bamias, Aristotelis ; Fléchon, Aude ; Gravis, Gwenaëlle ; Hussain, Syed ; Takano, Toshimi ; Leng, Ning ; Kadel, Edward E ; Banchereau, Romain ; Hegde, Priti S ; Mariathasan, Sanjeev ; Cui, Na ; Shen, Xiaodong ; Derleth, Christina L ; Green, Marjorie C ; Ravaud, Alain
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2018-02, Vol.391 (10122), p.748-757
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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Author / Creator:Banchereau, Romain ; Chitre, Avantika S. ; Scherl, Alexis ; Wu, Thomas D. ; Patil, Namrata S. ; de Almeida, Patricia ; Kadel, III, Edward E. ; Madireddi, Shravan ; Au-Yeung, Amelia ; Takahashi, Chikara ; Chen, Ying-Jiun ; Modrusan, Zora ; McBride, Jacqueline ; Nersesian, Rhea ; El-Gabry, Ehab A. ; Robida, Mark D. ; Hung, Jeffrey C. ; Kowanetz, Marcin ; Zou, Wei ; McCleland, Mark ; Caplazi, Patrick ; Eshgi, Shadi Toghi ; Koeppen, Hartmut ; Hegde, Priti S. ; Mellman, Ira ; Mathews, W. Rodney ; Powles, Thomas ; Mariathasan, Sanjeev ; Grogan, Jane ; O'Gorman, William E
Publisher:England: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2021-04, Vol.9 (4), p.e002231
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ArticlesPeer ReviewedFull Text
Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial
Author / Creator:Powles, Thomas ; Yuen, Kobe C. ; Gillessen, Silke ; Kadel, Edward E. ; Rathkopf, Dana ; Matsubara, Nobuaki ; Drake, Charles G. ; Fizazi, Karim ; Piulats, Josep M. ; Wysocki, Piotr J. ; Buchschacher, Gary L. ; Alekseev, Boris ; Mellado, Begoña ; Karaszewska, Bogusława ; Doss, Jennifer F. ; Rasuo, Grozdana ; Datye, Asim ; Mariathasan, Sanjeev ; Williams, Patrick ; Sweeney, Christopher J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2022-01, Vol.28 (1), p.144-153
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ArticlesPeer ReviewedFull Text
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)
Author / Creator:Kowanetz, Marcin ; Zou, Wei ; Gettinger, Scott N. ; Koeppen, Hartmut ; Kockx, Mark ; Schmid, Peter ; Kadel, Edward E. ; Wistuba, Ignacio ; Chaft, Jamie ; Rizvi, Naiyer A. ; Spigel, David R. ; Spira, Alexander ; Hirsch, Fred R. ; Cohen, Victor ; Smith, Dustin ; Boyd, Zach ; Miley, Natasha ; Flynn, Susan ; Leveque, Vincent ; Shames, David S. ; Ballinger, Marcus ; Mocci, Simonetta ; Shankar, Geetha ; Funke, Roel ; Hampton, Garret ; Sandler, Alan ; Amler, Lukas ; Mellman, Ira ; Chen, Daniel S. ; Hegde, Priti S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (43), p.E10119-E10126
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ArticlesPeer ReviewedFull Text
Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Author / Creator:Yuen, Kobe C. ; Liu, Li-Fen ; Gupta, Vinita ; Madireddi, Shravan ; Keerthivasan, Shilpa ; Li, Congfen ; Rishipathak, Deepali ; Williams, Patrick ; Kadel, Edward E. ; Koeppen, Hartmut ; Chen, Ying-Jiun ; Modrusan, Zora ; Grogan, Jane L. ; Banchereau, Romain ; Leng, Ning ; Thastrom, AnnChristine ; Shen, Xiadong ; Hashimoto, Kenji ; Tayama, Darren ; van der Heijden, Michiel S. ; Rosenberg, Jonathan E. ; McDermott, David F. ; Powles, Thomas ; Hegde, Priti S. ; Huseni, Mahrukh A. ; Mariathasan, Sanjeev
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2021-03, Vol.27 (3), p.560-560
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ArticlesPeer ReviewedFull Text
In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales
Author / Creator:Chen, Jieming ; Madireddi, Shravan ; Nagarkar, Deepti ; Migdal, Maciej ; Vander Heiden, Jason ; Chang, Diana ; Mukhyala, Kiran ; Selvaraj, Suresh ; Kadel, Edward E ; Brauer, Matthew J ; Mariathasan, Sanjeev ; Hunkapiller, Julie ; Jhunjhunwala, Suchit ; Albert, Matthew L ; Hammer, Christian
Publisher:Oxford University Press
Journal title:Briefings in bioinformatics, 2021-05, Vol.22 (3)
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ArticlesPeer ReviewedFull Text
Atezolizumab with enzalutamide vs enzalutamide alone in metastatic castration-resistant prostate cancer: a randomised phase 3 trial
Author / Creator:Powles, Thomas ; Yuen, Kobe C. ; Gillessen, Silke ; Kadel, Edward E. ; Rathkopf, Dana ; Matsubara, Nobuaki ; Drake, Charles G. ; Fizazi, Karim ; Piulats, Josep M. ; Wysocki, Piotr J. ; Buchschacher, Gary L. ; Alekseev, Boris ; Mellado, Begoña ; Karaszewska, Bogusława ; Doss, Jennifer F. ; Rasuo, Grozdana ; Datye, Asim ; Mariathasan, Sanjeev ; Williams, Patrick ; Sweeney, Christopher J.
Journal title:Nature medicine, 2022-01, Vol.28 (1), p.144-153
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ArticlesPeer ReviewedFull Text
High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade
Author / Creator:Yuen, Kobe C. ; Liu, Lifen ; Gupta, Vinita ; Madireddi, Shravan ; Keerthivasan, Shilpa ; Li, Congfen ; Rishipathak, Deepali ; Williams, Patrick ; Kadel, Edward E. ; Koeppen, Hartmut ; Chen, Ying-Jiun ; Modrusan, Zora ; Grogan, Jane L. ; Banchereau, Romain ; Leng, Ning ; Thastrom, AnnChristine ; Shen, Xiadong ; Hashimoto, Kenji ; Tayama, Darren ; van der Heijden, Michiel S. ; Rosenberg, Jonathan E. ; McDermott, David F. ; Powles, Thomas ; Hegde, Priti S. ; Huseni, Mahrukh A. ; Mariathasan, Sanjeev
Journal title:Nature medicine, 2020-05, Vol.26 (5), p.693-698
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ArticlesPeer ReviewedFull Text
Patient selection is key in IMbassador250
Author / Creator:Fenner, Annette
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Urology, 2022-03, Vol.19 (3), p.131-131
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ArticlesFull Text
In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales
Author / Creator:Chen, Jieming ; Madireddi, Shravan ; Nagarkar, Deepti ; Migdal, Maciej ; Jason Vander Heiden ; Chang, Diana ; Mukhyala, Kiran ; Selvaraj, Suresh ; Kadel, Edward E ; Brauer, Matthew J ; Mariathasan, Sanjeev ; Hunkapiller, Julie ; Jhunjhunwala, Suchit ; Albert, Matthew ; Hammer, Christian
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-04
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ArticlesPeer ReviewedFull Text
Atezolizumab as first-line therapy in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial
Author / Creator:Balar, Arjun V ; Galsky, Matthew D ; Rosenberg, Jonathan E ; Powles, Thomas ; Petrylak, Daniel P ; Bellmunt, Joaquim ; Loriot, Yohann ; Necchi, Andrea ; Hoffman-Censits, Jean ; Perez-Gracia, Jose Luis ; Dawson, Nancy A ; van der Heijden, Michiel S ; Dreicer, Robert ; Srinivas, Sandy ; Retz, Margitta M ; Joseph, Richard W ; Drakaki, Alexandra ; Vaishampayan, Ulka N ; Sridhar, Srikala S ; Quinn, David I ; Durán, Ignacio ; Shaffer, David R ; Eigl, Bernhard J ; Grivas, Petros D ; Yu, Evan Y ; Li, Shi ; Kadel, Edward E ; Boyd, Zachary ; Bourgon, Richard ; Hegde, Priti S ; Mariathasan, Sanjeev ; Thåström, AnnChristine ; Abidoye, Oyewale O ; Fine, Gregg D ; Bajorin, Dean F
Journal title:The Lancet (British edition), 2016-12, Vol.389 (10064), p.67-76
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ArticlesPeer ReviewedFull Text
TGF attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Author / Creator:Mariathasan, Sanjeev ; Turley, Shannon J ; Nickles, Dorothee ; Castiglioni, Alessandra ; Yuen, Kobe ; Wang, Yulei ; Kadel III, Edward E ; Koeppen, Hartmut ; Astarita, Jillian L ; Cubas, Rafael ; Jhunjhunwala, Suchit ; Banchereau, Romain ; Yang, Yagai ; Guan, Yinghui ; Chalouni, Cecile ; Ziai, James ; enbabaolu, Yasin ; Santoro, Stephen ; Sheinson, Daniel ; Hung, Jeffrey ; Giltnane, Jennifer M ; Pierce, Andrew A ; Mesh, Kathryn ; Lianoglou, Steve ; Riegler, Johannes ; Carano, Richard A. D ; Eriksson, Pontus ; Hglund, Mattias ; Somarriba, Loan ; Halligan, Daniel L ; van der Heijden, Michiel S ; Loriot, Yohann ; Rosenberg, Jonathan E ; Fong, Lawrence ; Mellman, Ira ; Chen, Daniel S ; Green, Marjorie ; Derleth, Christina ; Fine, Gregg D ; Hegde, Priti S ; Bourgon, Richard ; Powles, Thomas
Publisher:Nature Publishing Group
Journal title:Nature (London), 2018-02, Vol.554 (7693), p.544
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

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Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

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Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial

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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

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Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial

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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)

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Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

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In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

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Atezolizumab with enzalutamide vs enzalutamide alone in metastatic castration-resistant prostate cancer: a randomised phase 3 trial

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High systemic and tumor-associated IL8 correlates with reduced clinical benefit of PD-L1 blockade

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Patient selection is key in IMbassador250

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In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

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Atezolizumab as first-line therapy in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

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TGF attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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