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ArticlesPeer ReviewedFull Text
Fast screening of covariates in population models empowered by machine learning
Author / Creator:Sibieude, Emeric ; Khandelwal, Akash ; Hesthaven, Jan S. ; Girard, Pascal ; Terranova, Nadia
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2021-08, Vol.48 (4), p.597-609
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Population pharmacokinetic model selection assisted by machine learning
Author / Creator:Sibieude, Emeric ; Khandelwal, Akash ; Girard, Pascal ; Hesthaven, Jan S. ; Terranova, Nadia
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2022-04, Vol.49 (2), p.257-270
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Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data
Author / Creator:Maiga, Mohamed ; Dembele, Laurent ; Courlet, Perrine ; Khandelwal, Akash ; Dara, Antoine ; Sogore, Fanta ; Diakité, Ousmaila ; Maiga, Fatoumata O. ; Dao, François ; Sissoko, Sekou ; Barre, Yacouba ; Goita, Siaka ; Diakite, Mahamadou ; Diakite, Seidina A. S. ; Djimde, Abdoulaye A. ; Oeuvray, Claude ; Spangenberg, Thomas ; Wicha, Sebastian G. ; Demarta-Gatsi, Claudia
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-09, Vol.15 (1), p.7659-11, Article 7659
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Time‐Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma
Author / Creator:Wilkins, Justin J. ; Brockhaus, Brigitte ; Dai, Haiqing ; Vugmeyster, Yulia ; White, Joleen T. ; Brar, Satjit ; Bello, Carlo L. ; Neuteboom, Berend ; Wade, Janet R. ; Girard, Pascal ; Khandelwal, Akash
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.415-427
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Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases
Author / Creator:Menshykau, Denis ; Sidhu, Jagdev ; Shaughnessy, Laura ; Lledo‐Garcia, Rocio ; Dua, Pinky ; Teil, Marie ; Khandelwal, Akash
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-11, Vol.13 (11), p.1904-1914
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Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
Author / Creator:Khandelwal, Akash ; Arez, Francisca ; Alves, Paula M. ; Badolo, Lassina ; Brito, Catarina ; Fischli, Christoph ; Fontinha, Diana ; Oeuvray, Claude ; Prudêncio, Miguel ; Rottmann, Matthias ; Wilkins, Justin ; Yalkinoglu, Özkan ; Bagchus, Wilhelmina M. ; Spangenberg, Thomas
Publisher:England: Springer Nature
Journal title:Malaria journal, 2022-05, Vol.21 (1), p.151-151, Article 151
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Variable or variate? A conundrum in pharmacometrics exposure–response models
Author / Creator:Grisic, Ana‐Marija ; Venkatakrishnan, Karthik ; French, Jonathan ; Khandelwal, Akash
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-02, Vol.12 (2), p.144-147
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Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab
Author / Creator:Terranova, Nadia ; French, Jonathan ; Dai, Haiqing ; Wiens, Matthew ; Khandelwal, Akash ; Ruiz‐Garcia, Ana ; Manitz, Juliane ; Heydebreck, Anja ; Ruisi, Mary ; Chin, Kevin ; Girard, Pascal ; Venkatakrishnan, Karthik
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-03, Vol.11 (3), p.333-347
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Model‐informed drug development supporting the approval of the avelumab flat‐dose regimen in patients with advanced renal cell carcinoma
Author / Creator:Masters, Joanna C. ; Khandelwal, Akash ; Pietro, Alessandra ; Dai, Haiqing ; Brar, Satjit
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-04, Vol.11 (4), p.458-468
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Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma
Author / Creator:Hu, Ping ; Dai, Haiqing Isaac ; Bourdage, James ; Zhou, Dongli ; Trang, Ky ; Kowalski, Karey ; Bello, Carlo ; Hibma, Jennifer ; Khandelwal, Akash ; Cowan, Kyra ; Dong, Jennifer ; Venkatakrishnan, Karthik ; Gao, Wei
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2024-03, Vol.17 (3), p.e13730-n/a
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Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non‐small cell lung cancer based on bintrafusp alfa trials
Author / Creator:Milenković‐Grišić, Ana‐Marija ; Terranova, Nadia ; Mould, Diane R. ; Vugmeyster, Yulia ; Mrowiec, Thomas ; Machl, Andreas ; Girard, Pascal ; Venkatakrishnan, Karthik ; Khandelwal, Akash
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-01, Vol.13 (1), p.143-153
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A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer
Author / Creator:Liu, Han ; Milenković‐Grišić, Ana‐Marija ; Krishnan, Sreenath M. ; Jönsson, Siv ; Friberg, Lena E. ; Girard, Pascal ; Venkatakrishnan, Karthik ; Vugmeyster, Yulia ; Khandelwal, Akash ; Karlsson, Mats O.
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1738-1750
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COVID-19 infection in patients with haematological disease - A tertiary centre experience from north India
Author / Creator:Aggarwal, Mukul ; Amjad, Mirza Saleem ; Khandelwal, Akash ; Kumar, Pradeep ; Dhawan, Rishi ; Dass, Jasmita ; Ganesh, Kumar Vishwanathan ; Khanna, Punit ; Singh, Akhil Kant ; Soni, Kapil Dev ; Agarwal, Richa ; Bairwa, Mohan ; Selvi, Arul ; Tyagi, Seema ; Seth, Tulika ; Mahapatra, Manoranjan ; Wig, Naveet ; Trikha, Anjan
Publisher:India: Medknow Publications & Media Pvt Ltd
Journal title:Indian Journal of Medical Research, 2022-05, Vol.155 (5&6), p.570-574
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Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study
Author / Creator:Grisic, Ana‐Marija ; Khandelwal, Akash ; Bertolino, Mauro ; Huisinga, Wilhelm ; Girard, Pascal ; Kloft, Charlotte
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2020-11, Vol.9 (11), p.628-638
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Improved estimation of ligand-macromolecule binding affinities by linear response approach using a combination of multi-mode MD simulation and QM/MM methods
Author / Creator:Khandelwal, Akash ; Balaz, Stefan
Publisher:Netherlands: Springer Nature B.V
Journal title:Journal of computer-aided molecular design, 2007-01, Vol.21 (1-3), p.131-137
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Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors
Author / Creator:Vugmeyster, Yulia ; Grisic, Ana-Marija ; Brockhaus, Brigitte ; Rueckert, Peter ; Ruisi, Mary ; Dai, Haiqing ; Khandelwal, Akash
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2022-07, Vol.61 (7), p.985-995
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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind,...
Author / Creator:McCarthy, James S ; Yalkinoglu, Özkan ; Odedra, Anand ; Webster, Rebecca ; Oeuvray, Claude ; Tappert, Aliona ; Bezuidenhout, Deon ; Giddins, Marla J ; Dhingra, Satish K ; Fidock, David A ; Marquart, Louise ; Webb, Lachlan ; Yin, Xiaoyan ; Khandelwal, Akash ; Bagchus, Wilhelmina M
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2021-12, Vol.21 (12), p.1713-1724
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Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1
Author / Creator:Vugmeyster, Yulia ; Grisic, Ana-Marija ; Wilkins, Justin J. ; Loos, Anja H. ; Hallwachs, Roland ; Osada, Motonobu ; Venkatakrishnan, Karthik ; Khandelwal, Akash
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2022-10, Vol.90 (4), p.369-379
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Rabies encephalitis
Author / Creator:Chaudhary, Shyam Chand ; Khandelwal, Akash ; Tandon, Ruchika ; Sawlani, Kamal Kumar
Publisher:England: BMJ Publishing Group LTD
Journal title:BMJ case reports, 2021-04, Vol.14 (4), p.e239249
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Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands
Author / Creator:van der Plas, Johan L ; Kuiper, Vincent P ; Bagchus, Wilhelmina M ; Bödding, Matthias ; Yalkinoglu, Özkan ; Tappert, Aliona ; Seitzinger, Andrea ; Spangenberg, Thomas ; Bezuidenhout, Deon ; Wilkins, Justin ; Oeuvray, Claude ; Dhingra, Satish K ; Thathy, Vandana ; Fidock, David A ; Smidt, Lisanne C A ; Roozen, Geert V T ; Koopman, Jan Pieter R ; Lamers, Olivia A C ; Sijtsma, Jeroen ; van Schuijlenburg, Roos ; Wessels, Els ; Meij, Pauline ; Kamerling, Ingrid M C ; Roestenberg, Meta ; Khandelwal, Akash
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2023-10, Vol.23 (10), p.1164-1174
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Showing 1 to 20 of 30 results

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Fast screening of covariates in population models empowered by machine learning

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Population pharmacokinetic model selection assisted by machine learning

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Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

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Time‐Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma

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Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases

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Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside

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Variable or variate? A conundrum in pharmacometrics exposure–response models

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Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab

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Model‐informed drug development supporting the approval of the avelumab flat‐dose regimen in patients with advanced renal cell carcinoma

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Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma

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Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non‐small cell lung cancer based on bintrafusp alfa trials

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A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer

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COVID-19 infection in patients with haematological disease - A tertiary centre experience from north India

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Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study

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Improved estimation of ligand-macromolecule binding affinities by linear response approach using a combination of multi-mode MD simulation and QM/MM methods

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Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors

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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind,...

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Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1

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Rabies encephalitis

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Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands

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