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Ppuri iyagi oe 7-p'yŏn : 2015-nyŏndo che 39-hoe Yi Sang Munhaksang chakp'umjip / [Kim Sum, Chŏn Sŏng t'ae, Cho Kyŏng nan, Yi P'yŏng jae, Yun Sŏng hŭi, Son Hong gyu, Han Yu ju, Yi Chang uk].

뿌리 이야기 외 7편 : 2015년도 제 39회 이상문학상 작품집 / [김숨, 전성태, 조경란, 이평재, 윤성희, 손홍규, 한유주, 이장욱].

Thermal stress induces dynamic changes in nuclear proteins and relevant physiology as a part of the heat shock response (HSR). However, how the nuclear HSR is fine-tuned for cellular homeostasis remains elusive. Here, we show that mitochondrial activity plays an important role in nuclear proteostasis and genome stability through two distinct HSR pathways. Mitochondrial ribosomal protein (MRP) depletion enhanced the nucleolar granule formation of HSP70 and ubiquitin during HSR while facilitating the recovery of damaged nuclear proteins and impaired nucleocytoplasmic transport. Treatment of the mitochondrial proton gradient uncoupler masked MRP-depletion effects, implicating oxidative phosphorylation in these nuclear HSRs. On the other hand, MRP depletion and a reactive oxygen species (ROS) scavenger non-additively decreased mitochondrial ROS generation during HSR, thereby protecting the nuclear genome from DNA damage. These results suggest that suboptimal mitochondrial activity sustains nuclear homeostasis under cellular stress, providing plausible evidence for optimal endosymbiotic evolution via mitochondria-to-nuclear communication.

Molecules and Cells, 2023, 46(6), , pp.374-386

Suboptimal Mitochondrial Activity Facilitates Nuclear Heat Shock Responses for Proteostasis and Genome Stability

Molecules and cells, 2023, Vol.46 (6), p.374-386

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Ppuri iyagi oe 7-p'yŏn : 2015-nyŏndo che 39-hoe Yi Sang Munhaksang chakp'umjip / [Kim Sum, Chŏn Sŏng t'ae, Cho Kyŏng nan, Yi P'yŏng jae, Yun Sŏng hŭi, Son Hong gyu, Han Yu ju, Yi Chang uk].

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Suboptimal Mitochondrial Activity Facilitates Nuclear Heat Shock Responses for Proteostasis and Genome Stability

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Suboptimal Mitochondrial Activity Facilitates Nuclear Heat Shock Responses for Proteostasis and Genome Stability

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