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ArticlesPeer ReviewedFull Text
Metabolic changes during B cell differentiation for the production of intestinal IgA antibody
Author / Creator:Kunisawa, Jun
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2017-04, Vol.74 (8), p.1503-1509
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ArticlesPeer ReviewedFull Text
Impact of the intestinal environment on the immune responses to vaccination
Author / Creator:Hosomi, Koji ; Kunisawa, Jun
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2020-10, Vol.38 (44), p.6959-6965
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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
Author / Creator:Hosomi, Koji ; Saito, Mayu ; Park, Jonguk ; Murakami, Haruka ; Shibata, Naoko ; Ando, Masahiro ; Nagatake, Takahiro ; Konishi, Kana ; Ohno, Harumi ; Tanisawa, Kumpei ; Mohsen, Attayeb ; Chen, Yi-An ; Kawashima, Hitoshi ; Natsume-Kitatani, Yayoi ; Oka, Yoshimasa ; Shimizu, Hidenori ; Furuta, Mari ; Tojima, Yoko ; Sawane, Kento ; Saika, Azusa ; Kondo, Saki ; Yonejima, Yasunori ; Takeyama, Haruko ; Matsutani, Akira ; Mizuguchi, Kenji ; Miyachi, Motohiko ; Kunisawa, Jun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-08, Vol.13 (1), p.4477-4477, Article 4477
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ArticlesPeer ReviewedFull Text
Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants
Author / Creator:Liu, Zilai ; Hosomi, Koji ; Kunisawa, Jun
Publisher:Kidlington: Elsevier Ltd
Journal title:Vaccine, 2022-08, Vol.40 (36), p.5399-5403
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A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo
Author / Creator:Kunisawa, Jun ; Hashimoto, Eri ; Ishikawa, Izumi ; Kiyono, Hiroshi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e32094-e32094
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ArticlesPeer ReviewedFull Text
Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Author / Creator:Goto, Yoshiyuki ; Obata, Takashi ; Kunisawa, Jun ; Sato, Shintaro ; Ivanov, Ivaylo I. ; Lamichhane, Aayam ; Takeyama, Natsumi ; Kamioka, Mariko ; Sakamoto, Mitsuo ; Matsuki, Takahiro ; Setoyama, Hiromi ; Imaoka, Akemi ; Uematsu, Satoshi ; Akira, Shizuo ; Domino, Steven E. ; Kulig, Paulina ; Becher, Burkhard ; Renauld, Jean-Christophe ; Sasakawa, Chihiro ; Umesaki, Yoshinori ; Benno, Yoshimi ; Kiyono, Hiroshi
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2014-09, Vol.345 (6202), p.1310-1310
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12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice
Author / Creator:Nagatake, Takahiro ; Shibata, Yuki ; Morimoto, Sakiko ; Node, Eri ; Sawane, Kento ; Hirata, So-ichiro ; Adachi, Jun ; Abe, Yuichi ; Isoyama, Junko ; Saika, Azusa ; Hosomi, Koji ; Tomonaga, Takeshi ; Kunisawa, Jun
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-05, Vol.11 (1), p.10426-10426, Article 10426
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Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system
Author / Creator:Lan, Huangwenxian ; Hosomi, Koji ; Kunisawa, Jun
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2019-09, Vol.37 (42), p.6232-6239
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Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells
Author / Creator:Nakamura, Yutaka ; Fuse, Yozen ; Komiyama, Seiga ; Nagatake, Takahiro ; Kunisawa, Jun ; Hase, Koji
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-04, Vol.13 (1), p.5398-5398, Article 5398
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ArticlesPeer ReviewedFull Text
Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity
Author / Creator:Nakamura, Yutaka ; Mimuro, Hitomi ; Kunisawa, Jun ; Furusawa, Yukihiro ; Takahashi, Daisuke ; Fujimura, Yumiko ; Kaisho, Tsuneyasu ; Kiyono, Hiroshi ; Hase, Koji
Publisher:New York: Nature Publishing Group US
Journal title:Mucosal immunology, 2020-07, Vol.13 (4), p.679-690
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ArticlesPeer ReviewedFull Text
Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
Author / Creator:Kishino, Shigenobu ; Takeuchi, Michiki ; Park, Si-Bum ; Hirata, Akiko ; Kitamura, Nahoko ; Kunisawa, Jun ; Kiyono, Hiroshi ; Iwamoto, Ryo ; Isobe, Yosuke ; Arita, Makoto ; Arai, Hiroyuki ; Ueda, Kazumitsu ; Shima, Jun ; Takahashi, Satomi ; Yokozeki, Kenzo ; Shimizu, Sakayu ; Ogawa, Jun
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (44), p.17808-17813
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Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors
Author / Creator:Kurashima, Yosuke ; Amiya, Takeaki ; Nochi, Tomonori ; Fujisawa, Kumiko ; Haraguchi, Takeshi ; Iba, Hideo ; Tsutsui, Hiroko ; Sato, Shintaro ; Nakajima, Sachiko ; Iijima, Hideki ; Kubo, Masato ; Kunisawa, Jun ; Kiyono, Hiroshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2012-09, Vol.3 (1), p.1034-1034, Article 1034
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ArticlesPeer ReviewedFull Text
Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
Author / Creator:Sonnenberg, Gregory F. ; Monticelli, Laurel A. ; Alenghat, Theresa ; Fung, Thomas C. ; Hutnick, Natalie A. ; Kunisawa, Jun ; Shibata, Naoko ; Grunberg, Stephanie ; Sinha, Rohini ; Zahm, Adam M. ; Tardif, Mélanie R. ; Sathaliyawala, Taheri ; Kubota, Masaru ; Farber, Donna L. ; Collman, Ronald G. ; Shaked, Abraham ; Fouser, Lynette A. ; Weiner, David B. ; Tessier, Philippe A. ; Friedman, Joshua R. ; Kiyono, Hiroshi ; Bushman, Frederic D. ; Chang, Kyong-Mi ; Artis, David
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-06, Vol.336 (6086), p.1321-1325
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ArticlesPeer ReviewedFull Text
Establishment of enterotype-specific antibodies for various diagnostic systems
Author / Creator:Yoshii, Ken ; Node, Eri ; Furuta, Mari ; Tojima, Yoko ; Matsunaga, Ayu ; Adachi, Jun ; Takaai, Narimi ; Morita, Makiko ; Hosomi, Koji ; Kunisawa, Jun
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-05, Vol.15 (1), p.16814-13, Article 16814
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ArticlesPeer ReviewedFull Text
Intestinal commensal microbiota and cytokines regulate Fut2⁺ Paneth cells for gut defense
Author / Creator:Kamioka, Mariko ; Goto, Yoshiyuki ; Nakamura, Kiminori ; Yokoi, Yuki ; Sugimoto, Rina ; Ohira, Shuya ; Kurashima, Yosuke ; Umemoto, Shingo ; Sato, Shintaro ; Kunisawa, Jun ; Takahashi, Yu ; Domino, Steven E. ; Renauld, Jean-Christophe ; Nakae, Susumu ; Iwakura, Yoichiro ; Ernst, Peter B. ; Ayabe, Tokiyoshi ; Kiyono, Hiroshi
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-01, Vol.119 (3), p.1-10
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ArticlesPeer ReviewedFull Text
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut
Author / Creator:Kunisawa, Jun ; Arita, Makoto ; Hayasaka, Takahiro ; Harada, Takashi ; Iwamoto, Ryo ; Nagasawa, Risa ; Shikata, Shiori ; Nagatake, Takahiro ; Suzuki, Hidehiko ; Hashimoto, Eri ; Kurashima, Yosuke ; Suzuki, Yuji ; Arai, Hiroyuki ; Setou, Mitsutoshi ; Kiyono, Hiroshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-06, Vol.5 (1), p.9750-9750, Article 9750
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A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells
Author / Creator:Kasahara, Nanaho ; Imi, Yukiko ; Amano, Reina ; Shinohara, Masakazu ; Okada, Kumiko ; Hosokawa, Yusei ; Imamori, Makoto ; Tomimoto, Chiaki ; Kunisawa, Jun ; Kishino, Shigenobu ; Ogawa, Jun ; Ogawa, Wataru ; Hosooka, Tetsuya
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-11, Vol.13 (1), p.18983-18983, Article 18983
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Potential for Tight Junction Protein–Directed Drug Development Using Claudin Binders and Angubindin-1
Author / Creator:Hashimoto, Yosuke ; Tachibana, Keisuke ; Krug, Susanne M. ; Kunisawa, Jun ; Fromm, Michael ; Kondoh, Masuo
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-08, Vol.20 (16), p.4016
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Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts
Author / Creator:Park, Jonguk ; Kato, Kumiko ; Murakami, Haruka ; Hosomi, Koji ; Tanisawa, Kumpei ; Nakagata, Takashi ; Ohno, Harumi ; Konishi, Kana ; Kawashima, Hitoshi ; Chen, Yi-An ; Mohsen, Attayeb ; Xiao, Jin-zhong ; Odamaki, Toshitaka ; Kunisawa, Jun ; Mizuguchi, Kenji ; Miyachi, Motohiko
Publisher:England: BioMed Central Ltd
Journal title:BMC microbiology, 2021-05, Vol.21 (1), p.151-151, Article 151
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NIBN Japan Microbiome Database, a database for exploring the correlations between human microbiome and health
Author / Creator:Chen, Yi-An ; Kawashima, Hitoshi ; Park, Jonguk ; Mohsen, Attayeb ; Hosomi, Koji ; Nakagata, Takashi ; Murakami, Haruka ; Nanri, Hinako ; Miyachi, Motohiko ; Kunisawa, Jun ; Mizuguchi, Kenji
Publisher:England: Nature Publishing Group
Journal title:Scientific reports, 2025-06, Vol.15 (1), p.19640-7
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Metabolic changes during B cell differentiation for the production of intestinal IgA antibody

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Impact of the intestinal environment on the immune responses to vaccination

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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

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Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants

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A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

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Innate lymphoid cells regulate intestinal epithelial cell glycosylation

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12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

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Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system

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Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

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Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

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Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

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Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

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Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

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Establishment of enterotype-specific antibodies for various diagnostic systems

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Intestinal commensal microbiota and cytokines regulate Fut2⁺ Paneth cells for gut defense

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Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

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A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells

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Potential for Tight Junction Protein–Directed Drug Development Using Claudin Binders and Angubindin-1

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Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts

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NIBN Japan Microbiome Database, a database for exploring the correlations between human microbiome and health

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