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ArticlesPeer ReviewedFull Text
Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations
Author / Creator:Yoshikai, Yasuhiro ; Mizuno, Tadahaya ; Nemoto, Shumpei ; Kusuhara, Hiroyuki
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-02, Vol.15 (1), p.1197-12, Article 1197
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Phase 0/microdosing approaches: time for mainstream application in drug development?
Author / Creator:Burt, Tal ; Young, Graeme ; Lee, Wooin ; Kusuhara, Hiroyuki ; Langer, Oliver ; Rowland, Malcolm ; Sugiyama, Yuichi
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2020-11, Vol.19 (11), p.801-818
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Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Author / Creator:Morita, Katsuhisa ; Mizuno, Tadahaya ; Kusuhara, Hiroyuki
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-08, Vol.10 (1), p.13139, Article 13139
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Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut
Author / Creator:Imaoka, Tomoki ; Onuki-Nagasaki, Reiko ; Kimura, Hiroshi ; Tai, Kempei ; Ishii, Mitsuharu ; Nozue, Ayaka ; Kaisaki, Ikuko ; Hoshi, Misa ; Watanabe, Kengo ; Maeda, Kazuya ; Kamizono, Takashi ; Yoshioka, Takahiro ; Fujimoto, Takashi ; Satoh, Taku ; Nakamura, Hiroko ; Ando, Osamu ; Kusuhara, Hiroyuki ; Ito, Yuzuru
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-12, Vol.14 (1), p.29921-12, Article 29921
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Investigation of chemical structure recognition by encoder–decoder models in learning progress
Author / Creator:Nemoto, Shumpei ; Mizuno, Tadahaya ; Kusuhara, Hiroyuki
Publisher:Cham: Springer International Publishing
Journal title:Journal of cheminformatics, 2023-04, Vol.15 (1), p.45-9, Article 45
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Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers
Author / Creator:Takehara, Issey ; Yoshikado, Takashi ; Ishigame, Keiko ; Mori, Daiki ; Furihata, Ken-ichi ; Watanabe, Nobuaki ; Ando, Osamu ; Maeda, Kazuya ; Sugiyama, Yuichi ; Kusuhara, Hiroyuki
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2018-07, Vol.35 (7), p.138-13, Article 138
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SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption
Author / Creator:Mimura, Yoshihisa ; Yasujima, Tomoya ; Inoue, Katsuhisa ; Akino, Shogo ; Namba, Chitaka ; Kusuhara, Hiroyuki ; Sekiguchi, Yutaro ; Ohta, Kinya ; Yamashiro, Takahiro ; Yuasa, Hiroaki
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2024-11, Vol.13
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ATP-binding cassette, subfamily G (ABCG family)
Author / Creator:Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Germany: Springer Nature B.V
Journal title:Pflügers Archiv, 2007-02, Vol.453 (5), p.735-744
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Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers
Author / Creator:Takehara, Issey ; Terashima, Hanano ; Nakayama, Takeshi ; Yoshikado, Takashi ; Yoshida, Miwa ; Furihata, Kenichi ; Watanabe, Nobuaki ; Maeda, Kazuya ; Ando, Osamu ; Sugiyama, Yuichi ; Kusuhara, Hiroyuki
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2017-08, Vol.34 (8), p.1601-1614
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Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components
Author / Creator:Mizuno, Tadahaya ; Kinoshita, Setsuo ; Ito, Takuya ; Maedera, Shotaro ; Kusuhara, Hiroyuki
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-02, Vol.9 (1), p.1824, Article 1824
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Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure
Author / Creator:Tsuboya Ayako ; Kubota Yutaro ; Ishida Hiroo ; Ohkuma Ryotaro ; Ishiguro Tomoyuki ; Hirasawa Yuya ; Ariizumi Hirotsugu ; Tsunoda Takuya ; Sasaki Yasutsuna ; Matsumoto Natsumi ; Kondo Yusuke ; Tomoda Yukana ; Kusuhara Hiroyuki ; Fujita Ken-ichi
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer chemotherapy and pharmacology, 2021-09, Vol.88 (3), p.543-553
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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
Author / Creator:Tamura, Ryutaro ; Sabu, Yusuke ; Mizuno, Tadahaya ; Mizuno, Seiya ; Nakano, Satoshi ; Suzuki, Mitsuyoshi ; Abukawa, Daiki ; Kaji, Shunsaku ; Azuma, Yoshihiro ; Inui, Ayano ; Okamoto, Tatsuya ; Shimizu, Seiichi ; Fukuda, Akinari ; Sakamoto, Seisuke ; Kasahara, Mureo ; Takahashi, Satoru ; Kusuhara, Hiroyuki ; Zen, Yoh ; Ando, Tomohiro ; Hayashi, Hisamitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-11, Vol.14 (1), p.6763-15, Article 6763
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PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
Author / Creator:Yoshikado, Takashi ; Toshimoto, Kota ; Maeda, Kazuya ; Kusuhara, Hiroyuki ; Kimoto, Emi ; Rodrigues, A. David ; Chiba, Koji ; Sugiyama, Yuichi
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2018-11, Vol.7 (11), p.739-747
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Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans
Author / Creator:Watanabe, Takao ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2010-12, Vol.37 (6), p.575-590
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Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset
Author / Creator:Azuma, Iori ; Mizuno, Tadahaya ; Morita, Katsuhisa ; Suzuki, Yutaka ; Kusuhara, Hiroyuki
Publisher:England: Oxford University Press
Journal title:NAR genomics and bioinformatics, 2024-03, Vol.6 (1), p.lqad111
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Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines
Author / Creator:Imai, Satoki ; Kikuchi, Ryota ; Tsuruya, Yuri ; Naoi, Sotaro ; Nishida, Sho ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2013-11, Vol.30 (11), p.2880-2890
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A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions
Author / Creator:Yoshikado, Takashi ; Maeda, Kazuya ; Furihata, Sawako ; Terashima, Hanano ; Nakayama, Takeshi ; Ishigame, Keiko ; Tsunemoto, Kazunobu ; Kusuhara, Hiroyuki ; Furihata, Ken-ichi ; Sugiyama, Yuichi
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2017-08, Vol.34 (8), p.1570-1583
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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies
Author / Creator:Yoshikado, Takashi ; Aoki, Yasunori ; Mochizuki, Tatsuki ; Rodrigues, A. David ; Chiba, Koji ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-10, Vol.11 (10), p.1341-1357
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Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis
Author / Creator:Imagawa, Kazuo ; Hayashi, Hisamitsu ; Sabu, Yusuke ; Tanikawa, Ken ; Fujishiro, Jun ; Kajikawa, Daigo ; Wada, Hiroki ; Kudo, Toyoichiro ; Kage, Masayoshi ; Kusuhara, Hiroyuki ; Sumazaki, Ryo
Publisher:London: Nature Publishing Group
Journal title:Journal of human genetics, 2018-05, Vol.63 (5), p.569-577
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A microsensing system for the in vivo real-time detection of local drug kinetics
Author / Creator:Ogata, Genki ; Ishii, Yuya ; Asai, Kai ; Sano, Yamato ; Nin, Fumiaki ; Yoshida, Takamasa ; Higuchi, Taiga ; Sawamura, Seishiro ; Ota, Takeru ; Hori, Karin ; Maeda, Kazuya ; Komune, Shizuo ; Doi, Katsumi ; Takai, Madoka ; Findlay, Ian ; Kusuhara, Hiroyuki ; Einaga, Yasuaki ; Hibino, Hiroshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature biomedical engineering, 2017-08, Vol.1 (8), p.654-666
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Showing 1 to 20 of 94 results

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Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations

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Phase 0/microdosing approaches: time for mainstream application in drug development?

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Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor

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Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut

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Investigation of chemical structure recognition by encoder–decoder models in learning progress

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Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

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SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

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ATP-binding cassette, subfamily G (ABCG family)

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Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

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Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components

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Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure

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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

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PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

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Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

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Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset

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Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines

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A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions

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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

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Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis

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A microsensing system for the in vivo real-time detection of local drug kinetics

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