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ArticlesPeer ReviewedFull Text
PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin
Author / Creator:Hanke, Nina ; Frechen, Sebastian ; Moj, Daniel ; Britz, Hannah ; Eissing, Thomas ; Wendl, Thomas ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2018-10, Vol.7 (10), p.647-659
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Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale
Author / Creator:Bragazzi, Nicola Luigi ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Epidemiolgia (Basel, Switzerland), 2024-11, Vol.5 (4), p.669-691
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Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling
Author / Creator:Wojtyniak, Jan‐Georg ; Britz, Hannah ; Selzer, Dominik ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2020-06, Vol.9 (6), p.322-331
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Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions
Author / Creator:Britz, Hannah ; Hanke, Nina ; Taub, Mitchell E. ; Wang, Ting ; Prasad, Bhagwat ; Fernandez, Éric ; Stopfer, Peter ; Nock, Valerie ; Lehr, Thorsten
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2020-12, Vol.37 (12), p.250, Article 250
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Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampici...
Author / Creator:Türk, Denise ; Hanke, Nina ; Wolf, Sarah ; Frechen, Sebastian ; Eissing, Thomas ; Wendl, Thomas ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2019-12, Vol.58 (12), p.1595-1607
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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions
Author / Creator:Li, Xia ; Frechen, Sebastian ; Moj, Daniel ; Lehr, Thorsten ; Taubert, Max ; Hsin, Chih-hsuan ; Mikus, Gerd ; Neuvonen, Pertti J. ; Olkkola, Klaus T. ; Saari, Teijo I. ; Fuhr, Uwe
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2020-06, Vol.59 (6), p.781-808
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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach
Author / Creator:Fuhr, Laura Maria ; Marok, Fatima Zahra ; Hanke, Nina ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2021-02, Vol.13 (2), p.270
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A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions
Author / Creator:Türk, Denise ; Hanke, Nina ; Lehr, Thorsten
Publisher:MDPI
Journal title:Pharmaceutics, 2020-11, Vol.12 (11), p.1074
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Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups
Author / Creator:Rüdesheim, Simeon ; Selzer, Dominik ; Fuhr, Uwe ; Schwab, Matthias ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-04, Vol.11 (4), p.494-511
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Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis
Author / Creator:Hüppe, Tobias ; Götz, Katharina M. ; Meiser, Andreas ; de Faria Fernandes, Andrea ; Maurer, Felix ; Groesdonk, Heinrich V. ; Volk, Thomas ; Lehr, Thorsten ; Kreuer, Sascha
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-10, Vol.13 (1), p.18132-18132, Article 18132
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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
Author / Creator:Lippert, Jörg ; Burghaus, Rolf ; Edginton, Andrea ; Frechen, Sebastian ; Karlsson, Mats ; Kovar, Andreas ; Lehr, Thorsten ; Milligan, Peter ; Nock, Valerie ; Ramusovic, Sergej ; Riggs, Matthew ; Schaller, Stephan ; Schlender, Jan ; Schmidt, Stephan ; Sevestre, Michaël ; Sjögren, Erik ; Solodenko, Juri ; Staab, Alexander ; Teutonico, Donato
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.878-882
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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates
Author / Creator:Kovar, Lukas ; Schräpel, Christina ; Selzer, Dominik ; Kohl, Yvonne ; Bals, Robert ; Schwab, Matthias ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2020-06, Vol.12 (6), p.578
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Target-Mediated Drug Disposition Pharmacokinetic–Pharmacodynamic Model of Bosentan and Endothelin-1
Author / Creator:Volz, Anke-Katrin ; Krause, Andreas ; Haefeli, Walter Emil ; Dingemanse, Jasper ; Lehr, Thorsten
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2017-12, Vol.56 (12), p.1499-1511
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A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in...
Author / Creator:Van de Werf, Frans, MD ; Brueckmann, Martina, MD ; Connolly, Stuart J., MD ; Friedman, Jeffrey, MD ; Granger, Christopher B., MD ; Härtter, Sebastian, PhD ; Harper, Ruth, MD ; Kappetein, Arie Pieter, MD ; Lehr, Thorsten, PhD ; Mack, Michael J., MD ; Noack, Herbert, PhD ; Eikelboom, John W., MD
Publisher:United States: Mosby, Inc
Journal title:The American heart journal, 2012-06, Vol.163 (6), p.931-937.e1
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A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling
Author / Creator:Fuhr, Laura Maria ; Marok, Fatima Zahra ; Mees, Maximilian ; Mahfoud, Felix ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2022-07, Vol.14 (7), p.1474
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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators
Author / Creator:Marok, Fatima Zahra ; Wojtyniak, Jan-Georg ; Fuhr, Laura Maria ; Selzer, Dominik ; Schwab, Matthias ; Weiss, Johanna ; Haefeli, Walter Emil ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2023-02, Vol.15 (2), p.679
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A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin
Author / Creator:Balazki, Pavel ; Schaller, Stephan ; Eissing, Thomas ; Lehr, Thorsten
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2020-06, Vol.9 (6), p.353-362
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Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicoki...
Author / Creator:Nordmeier, Frederike ; Sihinevich, Iryna ; Doerr, Adrian A. ; Walle, Nadja ; Laschke, Matthias W. ; Lehr, Thorsten ; Menger, Michael D. ; Schmidt, Peter H. ; Meyer, Markus R. ; Schaefer, Nadine
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Archives of toxicology, 2021-12, Vol.95 (12), p.3681-3693
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Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network
Author / Creator:Marok, Fatima Zahra ; Fuhr, Laura Maria ; Hanke, Nina ; Selzer, Dominik ; Lehr, Thorsten
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2021-03, Vol.13 (3), p.331
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In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier
Author / Creator:Kovar, Lukas ; Wien, Lena ; Selzer, Dominik ; Kohl, Yvonne ; Bals, Robert ; Lehr, Thorsten
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceuticals (Basel, Switzerland), 2022-02, Vol.15 (2), p.250
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PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin

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Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale

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Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

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Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions

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Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampici...

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

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A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

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Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

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Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

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Target-Mediated Drug Disposition Pharmacokinetic–Pharmacodynamic Model of Bosentan and Endothelin-1

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A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in...

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A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators

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A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin

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Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicoki...

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Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

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In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

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