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ArticlesPeer ReviewedFull Text
AAV-ie enables safe and efficient gene transfer to inner ear cells
Author / Creator:Tan, Fangzhi ; Chu, Cenfeng ; Qi, Jieyu ; Li, Wenyan ; You, Dan ; Li, Ke ; Chen, Xin ; Zhao, Weidong ; Cheng, Cheng ; Liu, Xiaoyi ; Qiao, Yunbo ; Su, Bing ; He, Shuijin ; Zhong, Chao ; Li, Huawei ; Chai, Renjie ; Zhong, Guisheng
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3733-10, Article 3733
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Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
Author / Creator:Koehler, Karl R ; Nie, Jing ; Longworth-Mills, Emma ; Liu, Xiao-Ping ; Lee, Jiyoon ; Holt, Jeffrey R ; Hashino, Eri
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2017-06, Vol.35 (6), p.583-589
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Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
Author / Creator:Lissa, Delphine ; Takahashi, Nobuyuki ; Desai, Parth ; Manukyan, Irena ; Schultz, Christopher W. ; Rajapakse, Vinodh ; Velez, Moises J. ; Mulford, Deborah ; Roper, Nitin ; Nichols, Samantha ; Vilimas, Rasa ; Sciuto, Linda ; Chen, Yuanbin ; Guha, Udayan ; Rajan, Arun ; Atkinson, Devon ; El Meskini, Rajaa ; Weaver Ohler, Zoe ; Thomas, Anish
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-04, Vol.13 (1), p.2023-16, Article 2023
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ArticlesPeer ReviewedFull Text
Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield
Author / Creator:Anazi, S ; Maddirevula, S ; Faqeih, E ; Alsedairy, H ; Alzahrani, F ; Shamseldin, H E ; Patel, N ; Hashem, M ; Ibrahim, N ; Abdulwahab, F ; Ewida, N ; Alsaif, H S ; Al sharif, H ; Alamoudi, W ; Kentab, A ; Bashiri, F A ; Alnaser, M ; AlWadei, A H ; Alfadhel, M ; Eyaid, W ; Hashem, A ; Al Asmari, A ; Saleh, M M ; AlSaman, A ; Alhasan, K A ; Alsughayir, M ; Al Shammari, M ; Mahmoud, A ; Al-Hassnan, Z N ; Al-Husain, M ; Osama Khalil, R ; Abd El.Meguid, N ; Masri, A ; Ali, R ; Ben-Omran, T ; El.Fishway, P ; Hashish, A ; Ercan Sencicek, A ; State, M ; Alazami, A M ; Salih, M A ; Altassan, N ; Arold, S T ; Abouelhoda, M ; Wakil, S M ; Monies, D ; Shaheen, R ; Alkuraya, F S
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2017-04, Vol.22 (4), p.615-624
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Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Author / Creator:Shu, Yilai ; Li, Wenyan ; Huang, Mingqian ; Quan, Yi-Zhou ; Scheffer, Deborah ; Tian, Chunjie ; Tao, Yong ; Liu, Xuezhong ; Hochedlinger, Konrad ; Indzhykulian, Artur A. ; Wang, Zhengmin ; Li, Huawei ; Chen, Zheng-Yi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-12, Vol.10 (1), p.5530-15, Article 5530
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Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas
Author / Creator:Kervarrec, Thibault ; Tallet, Anne ; Miquelestorena-Standley, Elodie ; Houben, Roland ; Schrama, David ; Gambichler, Thilo ; Berthon, Patricia ; Le Corre, Yannick ; Hainaut-Wierzbicka, Ewa ; Aubin, Francois ; Bens, Guido ; Tabareau-Delalande, Flore ; Beneton, Nathalie ; Fromont, Gaëlle ; Arbion, Flavie ; Leteurtre, Emmanuelle ; Touzé, Antoine ; Samimi, Mahtab ; Guyétant, Serge
Publisher:New York: Nature Publishing Group US
Journal title:Modern pathology, 2019-04, Vol.32 (4), p.499-510
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Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea
Author / Creator:Atkinson, Patrick J. ; Dong, Yaodong ; Gu, Shuping ; Liu, Wenwen ; Najarro, Elvis Huarcaya ; Udagawa, Tomokatsu ; Cheng, Alan G.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-04, Vol.128 (4), p.1641-1656
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POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism
Author / Creator:Yu, Haoze V. ; Tao, Litao ; Llamas, Juan ; Wang, Xizi ; Nguyen, John D. ; Trecek, Talon ; Segil, Neil
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1-12
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Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells
Author / Creator:Sun, Suhong ; Li, Shuting ; Luo, Zhengnan ; Ren, Minhui ; He, Shunji ; Wang, Guangqin ; Liu, Zhiyong
Publisher:Cambridge: eLife Science Publications, Ltd
Journal title:eLife, 2021-09, Vol.10
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The role of Espin in the stereocilia regeneration and protection in Atoh1‐overexpressed cochlear epithelium
Author / Creator:Yang, Xuechun ; Qi, Jieyu ; Zhang, Liyan ; Tan, Fangzhi ; Huang, Hongming ; Xu, Chunlai ; Cui, Yong ; Chai, Renjie ; Wu, Peina
Publisher:England: John Wiley & Sons, Inc
Journal title:Cell proliferation, 2023-11, Vol.56 (11), p.e13483-e13483
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Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea
Author / Creator:Lee, Sungsu ; Song, Jae-Jun ; Beyer, Lisa A. ; Swiderski, Donald L. ; Prieskorn, Diane M. ; Acar, Melih ; Jen, Hsin-I ; Groves, Andrew K. ; Raphael, Yehoash
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-12, Vol.10 (1), p.21397-15, Article 21397
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GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor
Author / Creator:Jen, Hsin-I ; Singh, Sunita ; Tao, Litao ; Maunsell, Helen R. ; Segil, Neil ; Groves, Andrew K.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-05, Vol.12 (1), p.7793-7793, Article 7793
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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
Author / Creator:Iyer, Amrita A ; Hosamani, Ishwar ; Nguyen, John D ; Cai, Tiantian ; Singh, Sunita ; McGovern, Melissa M ; Beyer, Lisa ; Zhang, Hongyuan ; Jen, Hsin-I ; Yousaf, Rizwan ; Birol, Onur ; Sun, Jenny J ; Ray, Russell S ; Raphael, Yehoash ; Segil, Neil ; Groves, Andrew K
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2022-11, Vol.11
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The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function
Author / Creator:You, Dan ; Ni, Wenli ; Huang, Yikang ; Zhou, Qin ; Zhang, Yanping ; Jiang, Tao ; Chen, Yan ; Li, Wenyan
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2023-12, Vol.80 (12), p.349-349, Article 349
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Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
Author / Creator:Harold, Alexis ; Amako, Yutaka ; Hachisuka, Junichi ; Bai, Yulong ; Li, Meng Yen ; Kubat, Linda ; Gravemeyer, Jan ; Franks, Jonathan ; Gibbs, Julia R. ; Park, Hyun Jung ; Ezhkova, Elena ; Becker, Jürgen C. ; Shuda, Masahiro
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (40), p.20104-20114
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Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
Author / Creator:Menendez, Louise ; Trecek, Talon ; Gopalakrishnan, Suhasni ; Tao, Litao ; Markowitz, Alexander L ; Yu, Haoze V ; Wang, Xizi ; Llamas, Juan ; Huang, Chichou ; Lee, James ; Kalluri, Radha ; Ichida, Justin ; Segil, Neil
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2020-06, Vol.9
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High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor
Author / Creator:Yamashita, Tetsuji ; Zheng, Fei ; Finkelstein, David ; Kellard, Zoe ; Carter, Robert ; Rosencrance, Celeste D. ; Sugino, Ken ; Easton, John ; Gawad, Charles ; Zuo, Jian
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2018-07, Vol.14 (7), p.e1007552-e1007552
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Intracellular pH dynamics regulates intestinal stem cell lineage specification
Author / Creator:Liu, Yi ; Reyes, Efren ; Castillo-Azofeifa, David ; Klein, Ophir D. ; Nystul, Todd ; Barber, Diane L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-06, Vol.14 (1), p.3745-18, Article 3745
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Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle
Author / Creator:Wang, Tian ; Yang, Tian ; Kedaigle, Amanda ; Pregernig, Gabriela ; McCarthy, Ryan ; Holmes, Ben ; Wu, Xudong ; Becker, Lars ; Pan, Ning ; So, Kathy ; Chen, Leon ; He, Jun ; Mahmoudi, Ahmad ; Negi, Soumya ; Kowalczyk, Monika ; Gibson, Tyler ; Druckenbrod, Noah ; Cheng, Alan G. ; Burns, Joseph
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-10, Vol.15 (1), p.9166-17, Article 9166
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Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?
Author / Creator:Noben, Manuel ; Verstockt, Bram ; de Bruyn, Magali ; Hendriks, Nikolai ; Van Assche, Gert ; Vermeire, Séverine ; Verfaillie, Catherine ; Ferrante, Marc
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2017-12, Vol.66 (12), p.2193-2195
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Showing 1 to 20 of 184 results

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AAV-ie enables safe and efficient gene transfer to inner ear cells

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Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

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Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

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Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield

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Renewed proliferation in adult mouse cochlea and regeneration of hair cells

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Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

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Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea

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POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism

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Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

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The role of Espin in the stereocilia regeneration and protection in Atoh1‐overexpressed cochlear epithelium

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Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea

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GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

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The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function

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Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

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Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

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High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

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Intracellular pH dynamics regulates intestinal stem cell lineage specification

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Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle

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Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?

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