Access

Format

Author / Creator

Subject

Recently added

Eresources

Language

Place of Publication

Dates

Location

Hidden in plain sight : contributions of Aboriginal peoples to Canadian identity and culture / edited by David R. Newhouse, Cora J. Voyageur, Dan Beavon.

Sub-series 1: General manuscripts, various authors, 1891-1973

ABSTRACT
Objectives
The 2012 United States Preventive Services Task Force (USPSTF) Grade D recommendation against prostate‐specific antigen (PSA) screening has resulted in a shift to higher‐stage prostate cancer (PC) at diagnosis. We evaluate the utilization of radical prostatectomy (RP) versus radiation therapy (RT) in the US for Gleason grade group 5 (GG5) prostate cancer before and after 2012.
Methods
We identified 34,011 men with localized GG5 PC undergoing primary therapy with (1) RP or (2) RT + androgen deprivation therapy (ADT) between 2004 and 2017 from the National Cancer Database. The chi‐square test was used to compare the relative use of RP and RT before versus after 2012. Annual use of RP versus RT from 2004 to 2017 was compared using Cochran‐Armitage test for trend. We modeled the effect of treatment year on the use of RP using multivariable logistic regression.
Results
Across all centers, the use of RP increased from 31% to 41% (p for trend < 0.001). 2012 was associated with significant inflection for increase in RP use in all centers. There was an increased odds of receiving RP after 2012 (adjusted OR 1.34, 95% CI 1.28–1.40, p < 0.001).
Conclusions
Utilization of RP for GG5 PC has significantly increased in the United States over the past decade. It remains unknown if outcomes may be compromised in this group of high‐risk men, many of whom require post‐prostatectomy RT and/or ADT. Prospective comparison of RP versus RT + ADT for GG5 PC are needed to determine optimal treatment for these patients.

Cancer medicine (Malden, MA), 2025-02, Vol.14 (3), p.e70624-n/a

Utilization of Radical Prostatectomy Versus Radiation Therapy for Gleason Grade Group 5 Prostate Cancer Before and After USPSTF Grade D Recommendation Against Prostate‐Specific Antigen Screening in 2012

This study aims to develop a digital twin (DT) framework to enhance adaptive proton stereotactic body radiation therapy (SBRT) for prostate cancer. Prostate SBRT has emerged as a leading option for external beam radiotherapy due to its effectiveness and reduced treatment duration. However, interfractional anatomy variations can impact treatment outcomes. This study seeks to address these uncertainties using DT concept, with the goal of improving treatment quality, potentially revolutionizing prostate radiotherapy to offer personalized treatment solutions. Our study presented a pioneering approach that leverages DT technology to enhance adaptive proton SBRT. The framework improves treatment plans by utilizing patient-specific CTV setup uncertainty, which is usually smaller than conventional clinical setups. This research contributes to the ongoing efforts to enhance the efficiency and efficacy of prostate radiotherapy, with ultimate goals of improving patient outcomes and life quality.

arXiv.org, 2024-05

Adaptive Proton Therapy Using CBCT-Guided Digital Twins

Export record to excel

Export this record

Export record to excel

Hidden in plain sight : contributions of Aboriginal peoples to Canadian identity and culture / edited by David R. Newhouse, Cora J. Voyageur, Dan Beavon.

Export this record

Export record to excel

Sub-series 1: General manuscripts, various authors, 1891-1973

Export this record

Export record to excel

Utilization of Radical Prostatectomy Versus Radiation Therapy for Gleason Grade Group 5 Prostate Cancer Before and After USPSTF Grade D Recommendation Against Prostate‐Specific Antigen Screening in 20...

Export this record

Export record to excel

Adaptive Proton Therapy Using CBCT-Guided Digital Twins

Refine your search

Search the collection

Export record to excel

Export this record

Export record to excel

Hidden in plain sight : contributions of Aboriginal peoples to Canadian identity and culture / edited by David R. Newhouse, Cora J. Voyageur, Dan Beavon.

Export this record

Export record to excel

Sub-series 1: General manuscripts, various authors, 1891-1973

Export this record

Export record to excel

Utilization of Radical Prostatectomy Versus Radiation Therapy for Gleason Grade Group 5 Prostate Cancer Before and After USPSTF Grade D Recommendation Against Prostate‐Specific Antigen Screening in 20...

Export this record

Export record to excel

Adaptive Proton Therapy Using CBCT-Guided Digital Twins

Refine your search