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Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A
Author / Creator:Yang, Chen ; Zhao, Xinhao ; Sun, Dakang ; Yang, Leilei ; Chong, Chang ; Pan, Yu ; Chi, Xiumei ; Gao, Yanhang ; Wang, Moli ; Shi, Xiaodong ; Sun, Haibo ; Lv, Juan ; Gao, Yuanda ; Zhong, Jin ; Niu, Junqi ; Sun, Bing
Publisher:London: Nature Publishing Group UK
Journal title:Cellular & molecular immunology, 2016-01, Vol.13 (1), p.94-102
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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Author / Creator:Gao, Min ; Nettles, Richard E. ; Belema, Makonen ; Snyder, Lawrence B. ; Nguyen, Van N. ; Fridell, Robert A. ; Serrano-Wu, Michael H. ; Langley, David R. ; Sun, Jin-Hua ; O’Boyle II, Donald R. ; Lemm, Julie A. ; Wang, Chunfu ; Knipe, Jay O. ; Chien, Caly ; Colonno, Richard J. ; Grasela, Dennis M. ; Meanwell, Nicholas A. ; Hamann, Lawrence G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-05, Vol.465 (7294), p.96-100
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DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A
Author / Creator:Coelmont, Lotte ; Hanoulle, Xavier ; Chatterji, Udayan ; Berger, Carola ; Snoeck, Joke ; Bobardt, Michael ; Lim, Precious ; Vliegen, Inge ; Paeshuyse, Jan ; Vuagniaux, Grégoire ; Vandamme, Anne-Mieke ; Bartenschlager, Ralf ; Gallay, Philippe ; Lippens, Guy ; Neyts, Johan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-10, Vol.5 (10), p.e13687
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A key role for hepatitis C virus NS5A serine 225 phosphorylation revealed by super-resolution microscopy
Author / Creator:Goonawardane, Niluka ; Yin, Chunhong ; Roberts, Grace C ; Zothner, Carsten ; Harris, Mark
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.9567-14, Article 9567
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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus
Author / Creator:Liman, Wissal ; Oubahmane, Mehdi ; Lahcen, Nouhaila Ait ; Hdoufane, Ismail ; Cherqaoui, Driss ; Daoud, Rachid ; El Allali, Achraf
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-12, Vol.14 (1), p.31655-15, Article 31655
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Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
Author / Creator:Guedj, Jeremie ; Dahari, Harel ; Rong, Libin ; Sansone, Natasha D. ; Nettles, Richard E. ; Cotler, Scott J. ; Layden, Thomas J. ; Uprichard, Susan L. ; Perelson, Alan S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3991-3996
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Retreatment With Sofosbuvir Plus Grazoprevir/Elbasvir Plus Ribavirin of Patients With Hepatitis C Virus Genotype 1 or 4 Who Previously Failed an NS5A- or NS3-Containing Regimen: The ANRS HC34 REVENGE...
Author / Creator:de Lédinghen, Victor ; Laforest, Claire ; Hézode, Christophe ; Pol, Stanislas ; Renault, Alain ; Alric, Laurent ; Larrey, Dominique ; Métivier, Sophie ; Tran, Albert ; Jézéquel, Caroline ; Samuel, Didier ; Zoulim, Fabien ; Tual, Christelle ; Pailhé, Aurélie ; Gibowski, Séverine ; Bourlière, Marc ; Bellissant, Eric ; Pawlotsky, Jean-Michel
Publisher:United States
Journal title:Clinical infectious diseases, 2018-03, Vol.66 (7), p.1013-1018
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NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles
Author / Creator:Chen, Shucheng ; Harris, Mark
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2023-02, Vol.19 (2), p.e1010812
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Human Hepatitis C Virus NS5A Protein Alters Intracellular Calcium Levels, Induces Oxidative Stress, and Activates STAT-3 and NF-κB
Author / Creator:Gong, Guozhong ; Waris, Gulam ; Tanveer, Rasheeda ; Siddiqui, Aleem
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (17), p.9599-9604
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A role for domain I of the hepatitis C virus NS5A protein in virus assembly
Author / Creator:Yin, Chunhong ; Goonawardane, Niluka ; Stewart, Hazel ; Harris, Mark
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2018-01, Vol.14 (1), p.e1006834
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Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
Author / Creator:Kim, Nari ; Kim, Min-Jung ; Sung, Pil Soo ; Bae, Yong Chul ; Shin, Eui-Cheol ; Yoo, Joo-Yeon
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-02, Vol.7 (1), p.10631-10631, Article 10631
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Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
Author / Creator:Bertoli, Ada ; Sorbo, Maria Chiara ; Aragri, Marianna ; Lenci, Ilaria ; Teti, Elisabetta ; Polilli, Ennio ; Di Maio, Velia Chiara ; Gianserra, Laura ; Biliotti, Elisa ; Masetti, Chiara ; Magni, Carlo F. ; Babudieri, Sergio ; Nicolini, Laura A. ; Milana, Martina ; Cacciatore, Pierluigi ; Sarmati, Loredana ; Pellicelli, Adriano ; Paolucci, Stefania ; Craxì, Antonio ; Morisco, Filomena ; Palitti, Valeria Pace ; Siciliano, Massimo ; Coppola, Nicola ; Iapadre, Nerio ; Puoti, Massimo ; Rizzardini, Giuliano ; Taliani, Gloria ; Pasquazzi, Caterina ; Andreoni, Massimo ; Parruti, Giustino ; Angelico, Mario ; Perno, Carlo Federico ; Cento, Valeria ; Ceccherini-Silberstein, Francesca
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-06, Vol.8 (1), p.8988-11, Article 8988
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Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches
Author / Creator:Ikram, Aqsa ; Zaheer, Tahreem ; Awan, Faryal Mehwish ; Obaid, Ayesha ; Naz, Anam ; Hanif, Rumeza ; Paracha, Rehan Zafar ; Ali, Amjad ; Naveed, Abdul Khaliq ; Janjua, Hussnain Ahmed
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-10, Vol.8 (1), p.16107-14, Article 16107
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Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
Author / Creator:Ascher, David B. ; Wielens, Jerome ; Nero, Tracy L. ; Doughty, Larissa ; Morton, Craig J. ; Parker, Michael W.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2014-04, Vol.4 (1), p.4765, Article 4765
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Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
Author / Creator:Sistayanarain, Anchalee ; Kunthalert, Duangkamol
Publisher:Berlin: Springer Nature B.V
Journal title:Archives of microbiology, 2024-05, Vol.206 (5), p.215
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The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A
Author / Creator:Reiss, Simon ; Harak, Christian ; Romero-Brey, Inés ; Radujkovic, Danijela ; Klein, Rahel ; Ruggieri, Alessia ; Rebhan, Ilka ; Bartenschlager, Ralf ; Lohmann, Volker
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-05, Vol.9 (5), p.e1003359
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NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir
Author / Creator:Uemura, Hayato ; Uchida, Yoshihito ; Kouyama, Jun-ichi ; Naiki, Kayoko ; Tsuji, Shohei ; Sugawara, Kayoko ; Nakao, Masamitsu ; Motoya, Daisuke ; Nakayama, Nobuaki ; Imai, Yukinori ; Tomiya, Tomoaki ; Mochida, Satoshi
Publisher:Tokyo: Springer Japan
Journal title:Journal of gastroenterology, 2019-05, Vol.54 (5), p.459-470
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Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes
Author / Creator:Perrin-Cocon, Laure ; Kundlacz, Cindy ; Jacquemin, Clémence ; Hanoulle, Xavier ; Aublin-Gex, Anne ; Figl, Marianne ; Manteca, Jeremy ; André, Patrice ; Vidalain, Pierre-Olivier ; Lotteau, Vincent ; Diaz, Olivier
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-01, Vol.23 (2), p.919
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A Novel Simple Assay System to Quantify the Percent HCV-RNA Levels of NS5A Y93H Mutant Strains and Y93 Wild-Type Strains Relative to the Total HCV-RNA Levels to Determine the Indication for Antiviral...
Author / Creator:Uchida, Yoshihito ; Kouyama, Jun-ichi ; Naiki, Kayoko ; Mochida, Satoshi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-11, Vol.9 (11), p.e112647
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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
Author / Creator:Tellinghuisen, Timothy L. ; Foss, Katie L. ; Treadaway, Jason
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2008-03, Vol.4 (3), p.e1000032
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Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

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DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

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A key role for hepatitis C virus NS5A serine 225 phosphorylation revealed by super-resolution microscopy

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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus

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Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

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Retreatment With Sofosbuvir Plus Grazoprevir/Elbasvir Plus Ribavirin of Patients With Hepatitis C Virus Genotype 1 or 4 Who Previously Failed an NS5A- or NS3-Containing Regimen: The ANRS HC34 REVENGE...

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NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles

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Human Hepatitis C Virus NS5A Protein Alters Intracellular Calcium Levels, Induces Oxidative Stress, and Activates STAT-3 and NF-κB

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A role for domain I of the hepatitis C virus NS5A protein in virus assembly

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Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

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Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy

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Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches

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Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

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Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors

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The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A

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NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir

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Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

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A Novel Simple Assay System to Quantify the Percent HCV-RNA Levels of NS5A Y93H Mutant Strains and Y93 Wild-Type Strains Relative to the Total HCV-RNA Levels to Determine the Indication for Antiviral...

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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

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