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Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition
Author / Creator:Solbak, Sara M. Ø. ; Abdurakhmanov, Eldar ; Vedeler, Anni ; Danielson, U. Helena
Publisher:England: BioMed Central Ltd
Journal title:Virology journal, 2017-12, Vol.14 (1), p.236-236, Article 236
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L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions
Author / Creator:Svarovskaia, Evguenia S. ; Gane, Edward ; Dvory-Sobol, Hadas ; Martin, Ross ; Doehle, Brian ; Hedskog, Charlotte ; Jacobson, Ira M. ; Nelson, David R. ; Lawitz, Eric ; Brainard, Diana M. ; McHutchison, John G. ; Miller, Michael D. ; Mo, Hongmei
Publisher:United States: Oxford University Press
Journal title:The Journal of infectious diseases, 2016-04, Vol.213 (8), p.1240-1247
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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir
Author / Creator:Kirby, Brian J. ; Symonds, William T. ; Kearney, Brian P. ; Mathias, Anita A.
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2015-07, Vol.54 (7), p.677-690
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Discovery of Novel HCV NS5B polymerase inhibitor, 2‐(3,4‐dimethyl‐5,5‐dioxidobenzo[e]pyrazolo[4,3‐c][1,2]thiazin‐2(4H)‐yl)‐N‐(2‐fluorobenzyl)acetamide via molecular docking and experimental approach
Author / Creator:Khalid, Hina ; Shahid, Sana ; Tariq, Somayya ; Ijaz, Bushra ; Ashfaq, Usman Ali ; Ahmad, Matloob
Publisher:Australia: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2021-12, Vol.48 (12), p.1653-1661
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Anti-BVDV Activity of Traditional Chinese Medicine Monomers Targeting NS5B (RNA-Dependent RNA Polymerase) In Vitro and In Vivo
Author / Creator:Chen, Nannan ; Jiang, Dongjun ; Shao, Baihui ; Bai, Tongtong ; Chen, Jinwei ; Liu, Yu ; Zhang, Zecai ; Zhou, Yulong ; Wang, Xue ; Zhu, Zhanbo
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-04, Vol.28 (8), p.3413
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In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir
Author / Creator:Tong, Xiao ; Le Pogam, Sophie ; Li, Lewyn ; Haines, Kristin ; Piso, Katherine ; Baronas, Victoria ; Yan, Jun-Mei ; So, Sung-Sau ; Klumpp, Klaus ; Nájera, Isabel
Publisher:Oxford: Oxford University Press
Journal title:The Journal of infectious diseases, 2014-03, Vol.209 (5), p.668-675
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Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches
Author / Creator:Ikram, Aqsa ; Zaheer, Tahreem ; Awan, Faryal Mehwish ; Obaid, Ayesha ; Naz, Anam ; Hanif, Rumeza ; Paracha, Rehan Zafar ; Ali, Amjad ; Naveed, Abdul Khaliq ; Janjua, Hussnain Ahmed
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-10, Vol.8 (1), p.16107-14, Article 16107
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Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
Author / Creator:Bertoli, Ada ; Sorbo, Maria Chiara ; Aragri, Marianna ; Lenci, Ilaria ; Teti, Elisabetta ; Polilli, Ennio ; Di Maio, Velia Chiara ; Gianserra, Laura ; Biliotti, Elisa ; Masetti, Chiara ; Magni, Carlo F. ; Babudieri, Sergio ; Nicolini, Laura A. ; Milana, Martina ; Cacciatore, Pierluigi ; Sarmati, Loredana ; Pellicelli, Adriano ; Paolucci, Stefania ; Craxì, Antonio ; Morisco, Filomena ; Palitti, Valeria Pace ; Siciliano, Massimo ; Coppola, Nicola ; Iapadre, Nerio ; Puoti, Massimo ; Rizzardini, Giuliano ; Taliani, Gloria ; Pasquazzi, Caterina ; Andreoni, Massimo ; Parruti, Giustino ; Angelico, Mario ; Perno, Carlo Federico ; Cento, Valeria ; Ceccherini-Silberstein, Francesca
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-06, Vol.8 (1), p.8988-11, Article 8988
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Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors
Author / Creator:Nasr, Tamer ; Aboshanab, Ahmed ; Mpekoulis, George ; Drakopoulos, Antonios ; Vassilaki, Niki ; Zoidis, Grigoris ; Abouzid, Khaled ; Zaghary, Wafaa
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2022-12, Vol.14 (12), p.2767
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Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients
Author / Creator:Paolucci, Stefania ; Fiorina, Loretta ; Mariani, Bianca ; Gulminetti, Roberto ; Novati, Stefano ; Barbarini, Giorgio ; Bruno, Raffaele ; Baldanti, Fausto
Publisher:England: Springer-Verlag
Journal title:Virology journal, 2013-12, Vol.10 (1), p.355-355, Article 355
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PKM2 Facilitates Classical Swine Fever Virus Replication by Enhancing NS5B Polymerase Function
Author / Creator:Song, Mengzhao ; Liu, Shanchuan ; Luo, Yan ; Ji, Tiantian ; Zhang, Yanming ; Deng, Wen
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2025-04, Vol.17 (5), p.648
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StackHCV: a web-based integrative machine-learning framework for large-scale identification of hepatitis C virus NS5B inhibitors
Author / Creator:Malik, Aijaz Ahmad ; Warot, Chotpatiwetchkul ; Phanus-umporn Chuleeporn ; Nantasenamat Chanin ; Phasit, Charoenkwan ; Watshara, Shoombuatong
Publisher:Dordrecht: Springer Nature B.V
Journal title:Journal of computer-aided molecular design, 2021-10, Vol.35 (10), p.1037-1053
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Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C
Author / Creator:Ahmed, Hala Rady ; Waly, Nancy G. F. M. ; Abd El-Baky, Rehab Mahmoud ; Yahia, Ramadan ; Hetta, Helal F. ; Elsayed, Amr M. ; Ibrahem, Reham Ali
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-04, Vol.16 (4), p.e0249770
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microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3′ untranslated region: function in replication and influence of RNA secondary structure
Author / Creator:Gerresheim, Gesche K. ; Dünnes, Nadia ; Nieder-Röhrmann, Anika ; Shalamova, Lyudmila A. ; Fricke, Markus ; Hofacker, Ivo ; Höner zu Siederdissen, Christian ; Marz, Manja ; Niepmann, Michael
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2017-02, Vol.74 (4), p.747-760
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Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors
Author / Creator:Boyce, Sarah E. ; Tirunagari, Neeraj ; Niedziela-Majka, Anita ; Perry, Jason ; Wong, Melanie ; Kan, Elaine ; Lagpacan, Leanna ; Barauskas, Ona ; Hung, Magdeleine ; Fenaux, Martijn ; Appleby, Todd ; Watkins, William J. ; Schmitz, Uli ; Sakowicz, Roman
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014, Vol.9 (1), p.e84808
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Diversity of the hepatitis C virus NS5B gene during HIV co-infection
Author / Creator:Ngwaga, Tshegofatso ; Kong, Ling ; Lin, Derrick ; Schoborg, Cassandra ; Taylor, Lynn E. ; Mayer, Kenneth H. ; Klein, Robert S. ; Celentano, David D. ; Sobel, Jack D. ; Jamieson, Denise J. ; King, Caroline C. ; Tavis, John E. ; Blackard, Jason T.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-08, Vol.15 (8), p.e0237162
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Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein
Author / Creator:Lee, Chang Ho ; Lee, Soo-Han ; Kim, Ji Hyun ; Noh, Yook-Hwan ; Noh, Gyu-Jeong ; Lee, Seong-Wook
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2015-10, Vol.4 (10), p.e254-e254, Article e254
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Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking
Author / Creator:Wei, Yu ; Li, Jinlong ; Qing, Jie ; Huang, Mingjie ; Wu, Ming ; Gao, Fenghua ; Li, Dongmei ; Hong, Zhangyong ; Kong, Lingbao ; Huang, Weiqiang ; Lin, Jianping
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-02, Vol.11 (2), p.e0148181
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Using NS5B Sequencing for Hepatitis C Virus Genotyping Reveals Discordances with Commercial Platforms
Author / Creator:Chueca, Natalia ; Rivadulla, Isidro ; Lovatti, Rubén ; Reina, Gabriel ; Blanco, Ana ; Fernandez-Caballero, Jose Angel ; Cardeñoso, Laura ; Rodriguez-Granjer, Javier ; Fernandez-Alonso, Miriam ; Aguilera, Antonio ; Alvarez, Marta ; Galán, Juan Carlos ; García, Federico
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-04, Vol.11 (4), p.e0153754
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Prevalence and Pattern of Resistance in NS5A/NS5B in Hepatitis C Chronic Patients Genotype 3 Examined at a Public Health Laboratory in the State of São Paulo, Brazil
Author / Creator:de Torres Santos, Ana Paula ; Martins Silva, Vanessa Cristina ; Mendes-Corrêa, Maria Cássia ; Lemos, Marcilio Figueiredo ; de Mello Malta, Fernanda ; Santana, Rúbia Anita Ferraz ; Dastoli, Gregório Tadeu Fernando ; de Castro, Vanessa Fusco Duarte ; Pinho, João Renato Rebello ; Moreira, Regina Célia
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Infection and drug resistance, 2021-01, Vol.14, p.723-730
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Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

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L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions

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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir

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Discovery of Novel HCV NS5B polymerase inhibitor, 2‐(3,4‐dimethyl‐5,5‐dioxidobenzo[e]pyrazolo[4,3‐c][1,2]thiazin‐2(4H)‐yl)‐N‐(2‐fluorobenzyl)acetamide via molecular docking and experimental approach

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Anti-BVDV Activity of Traditional Chinese Medicine Monomers Targeting NS5B (RNA-Dependent RNA Polymerase) In Vitro and In Vivo

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In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

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Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches

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Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy

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Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors

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Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients

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PKM2 Facilitates Classical Swine Fever Virus Replication by Enhancing NS5B Polymerase Function

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StackHCV: a web-based integrative machine-learning framework for large-scale identification of hepatitis C virus NS5B inhibitors

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Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C

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microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3′ untranslated region: function in replication and influence of RNA secondary structure

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Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

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Diversity of the hepatitis C virus NS5B gene during HIV co-infection

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Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

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Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking

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Using NS5B Sequencing for Hepatitis C Virus Genotyping Reveals Discordances with Commercial Platforms

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Prevalence and Pattern of Resistance in NS5A/NS5B in Hepatitis C Chronic Patients Genotype 3 Examined at a Public Health Laboratory in the State of São Paulo, Brazil

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