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ArticlesPeer ReviewedFull Text
Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults
Author / Creator:Bézay, Nicole ; Hochreiter, Romana ; Kadlecek, Vera ; Wressnigg, Nina ; Larcher-Senn, Julian ; Klingler, Anton ; Dubischar, Katrin ; Eder-Lingelbach, Susanne ; Leroux-Roels, Isabel ; Leroux-Roels, Geert ; Bender, Wolfgang
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2023-10, Vol.23 (10), p.1186-1196
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The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes
Author / Creator:Comstedt, Pär ; Schüler, Wolfgang ; Meinke, Andreas ; Lundberg, Urban
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-09, Vol.12 (9), p.e0184357-e0184357
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ArticlesPeer ReviewedFull Text
Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis
Author / Creator:Klouwens, M.J ; Salverda, M.L.M ; Trentelman, J.J ; Ersoz, J.I ; Wagemakers, A ; Gerritzen, M.J.H ; van der Ley, P.A ; Hovius, J.W
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2021-04, Vol.39 (18), p.2561-2567
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ArticlesPeer ReviewedFull Text
Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes
Author / Creator:Federizon, Jasmin ; Frye, Amber ; Huang, Wei-Chiao ; Hart, Thomas M ; He, Xuedan ; Beltran, Christopher ; Marcinkiewicz, Ashley L ; Mainprize, Iain L ; Wills, Melanie K.B ; Lin, Yi-Pin ; Lovell, Jonathan F
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2020-01, Vol.38 (4), p.942-950
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ArticlesPeer ReviewedFull Text
Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir
Author / Creator:Phillip, Kathryn ; Nair, Nisha ; Samanta, Kamalika ; Azevedo, Jose F ; Brown, Grant D ; Petersen, Christine A ; Gomes-Solecki, Maria
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2021-07, Vol.39 (31), p.4320-4327
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Relationship between Immunity to "Borrelia burgdorferi" Outer-surface Protein A (OspA) and Lyme Arthritis
Author / Creator:Steere, Allen C. ; Drouin, Elise E. ; Glickstein, Lisa J.
Publisher:United States: Oxford University Press
Journal title:Clinical infectious diseases, 2011-02, Vol.52 (suppl_3), p.S259-S265
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ArticlesPeer ReviewedFull Text
Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice
Author / Creator:Wang, Yang ; Esquivel, Rianne ; Flingai, Seleeke ; Schiller, Zachary A. ; Kern, Aurélie ; Agarwal, Sangya ; Chu, Jacqueline ; Patel, Ami ; Sullivan, Katherine ; Wise, Megan C. ; Broderick, Kate E. ; Hu, Linden ; Weiner, David B. ; Klempner, Mark S.
Publisher:United States: Oxford University Press
Journal title:The Journal of infectious diseases, 2019-03, Vol.219 (7), p.1146-1150
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ArticlesPeer ReviewedFull Text
The year that shaped the outcome of the OspA vaccine for human Lyme disease
Author / Creator:Dattwyler, Raymond J. ; Gomes-Solecki, Maria
Publisher:London: Nature Publishing Group UK
Journal title:npj vaccines, 2022-01, Vol.7 (1), p.10-10, Article 10
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ArticlesPeer ReviewedFull Text
Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes
Author / Creator:Wang, Yang ; Kern, Aurélie ; Boatright, Naomi K. ; Schiller, Zachary A. ; Sadowski, Andrew ; Ejemel, Monir ; Souders, Colby A. ; Reimann, Keith A. ; Hu, Linden ; Thomas, William D. ; Klempner, Mark S.
Publisher:United States: Oxford University Press
Journal title:The Journal of infectious diseases, 2016-07, Vol.214 (2), p.205-211
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ArticlesPeer ReviewedFull Text
Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development
Author / Creator:Izac, Jerilyn R ; Oliver, Lee D ; Earnhart, Christopher G ; Marconi, Richard T
Publisher:Netherlands: Elsevier Ltd
Journal title:Vaccine, 2017-05, Vol.35 (24), p.3178-3185
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ArticlesPeer ReviewedFull Text
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
Author / Creator:Alexopoulou, Lena ; Thomas, Venetta ; Schnare, Markus ; Lobet, Yves ; Anguita, Juan ; Schoen, Robert T. ; Medzhitov, Ruslan ; Fikrig, Erol ; Flavell, Richard A.
Publisher:New York: Nature Publishing Group US
Journal title:Nature Medicine, 2002-08, Vol.8 (8), p.878-884
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ArticlesPeer ReviewedFull Text
Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial
Author / Creator:Wressnigg, Nina, PhD ; Pöllabauer, Eva-Maria, MD ; Aichinger, Gerald, MD ; Portsmouth, Daniel, PhD ; Löw-Baselli, Alexandra, PhD ; Fritsch, Sandor, PhD ; Livey, Ian, PhD ; Crowe, Brian A, PhD ; Schwendinger, Michael, PhD ; Brühl, Peter, PhD ; Pilz, Andreas, PhD ; Dvorak, Thomas, PhD ; Singer, Julia, PhD ; Firth, Clair, MSc ; Luft, Benjamin, Prof ; Schmitt, Bernhard, MD ; Zeitlinger, Markus, MD ; Müller, Markus, Prof ; Kollaritsch, Herwig, Prof ; Paulke-Korinek, Maria, MD ; Esen, Meral, MD ; Kremsner, Peter G, Prof ; Ehrlich, Hartmut J, MD ; Barrett, P Noel, Dr
Publisher:London: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2013-08, Vol.13 (8), p.680-689
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Reference EntriesFull Text
OSPA
Publisher:Oxford University Press
Journal title:A Dictionary of Abbreviations, 2011
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ArticlesPeer ReviewedFull Text
Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters
Author / Creator:Grosenbaugh, Deborah A ; De Luca, Karelle ; Durand, Pierre-Yves ; Feilmeier, Bradley ; DeWitt, Kristopher ; Sigoillot-Claude, Cecile ; Sajous, Marie-Line ; Day, Michael J ; David, Frederic
Publisher:England: BioMed Central Ltd
Journal title:BMC veterinary research, 2018-10, Vol.14 (1), p.312-312, Article 312
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ArticlesPeer ReviewedFull Text
P-599. 6-Valent, OspA-Based VLA15 Lyme Disease Vaccine Candidate Against Lyme Borreliosis in a Healthy Pediatric and Adult Study Population: A Phase 2 Study Update
Author / Creator:Messier, Marc D ; Wagner, Laura ; Hochreiter, Romana ; Lamberth, Erik ; Larcher-Senn, Julian ; Simon, Raphael ; groark, James ; Stark, James H
Publisher:US: Oxford University Press
Journal title:Open forum infectious diseases, 2025-01, Vol.12 (Supplement_1)
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ArticlesPeer ReviewedFull Text
Evaluation of OspA Vaccination-Induced Serological Correlates of Protection against Lyme Borreliosis in a Mouse Model
Author / Creator:Schwendinger, Michael G. ; O'Rourke, Maria ; Traweger, Andreas ; Savidis-Dacho, Helga ; Pilz, Andreas ; Portsmouth, Daniel ; Livey, Ian ; Barrett, P. Noel ; Crowe, Brian A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-11, Vol.8 (11), p.e79022-e79022
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ArticlesPeer ReviewedFull Text
Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis
Author / Creator:Zhao, Hua ; Bao, Fukai Frank ; Liu, Aihua
Publisher:Italy: Journal of Infection in Developing Countries
Journal title:Journal of infection in developing countries, 2017-01, Vol.11 (1), p.1-9
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ArticlesPeer ReviewedFull Text
OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier
Author / Creator:Pulzova, Lucia ; Kovac, Andrej ; Mucha, Rastislav ; Mlynarcik, Patrik ; Bencurova, Elena ; Madar, Marian ; Novak, Michal ; Bhide, Mangesh
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2011-09, Vol.1 (1), p.86-86, Article 86
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ArticlesPeer ReviewedFull Text
Immune Response to Lactobacillus plantarum Expressing Borrelia burgdorferi OspA Is Modulated by the Lipid Modification of the Antigen
Author / Creator:del Rio, Beatriz ; Seegers, Jos F. M. L. ; Gomes-Solecki, Maria
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-06, Vol.5 (6), p.e11199-e11199
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ArticlesPeer ReviewedFull Text
A Generalized Labeled Multi-Bernoulli Filter Based on Track-before-Detect Measurement Model for Multiple-Weak-Target State Estimate Using Belief Propagation
Author / Creator:Cao, Chenghu ; Zhao, Yongbo
Publisher:Basel: MDPI AG
Journal title:Remote sensing (Basel, Switzerland), 2022-09, Vol.14 (17), p.4209
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Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults

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The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes

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Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis

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Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes

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Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir

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Relationship between Immunity to "Borrelia burgdorferi" Outer-surface Protein A (OspA) and Lyme Arthritis

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Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice

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The year that shaped the outcome of the OspA vaccine for human Lyme disease

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Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes

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Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development

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Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

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Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial

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OSPA

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Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters

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P-599. 6-Valent, OspA-Based VLA15 Lyme Disease Vaccine Candidate Against Lyme Borreliosis in a Healthy Pediatric and Adult Study Population: A Phase 2 Study Update

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Evaluation of OspA Vaccination-Induced Serological Correlates of Protection against Lyme Borreliosis in a Mouse Model

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Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis

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OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier

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Immune Response to Lactobacillus plantarum Expressing Borrelia burgdorferi OspA Is Modulated by the Lipid Modification of the Antigen

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A Generalized Labeled Multi-Bernoulli Filter Based on Track-before-Detect Measurement Model for Multiple-Weak-Target State Estimate Using Belief Propagation

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