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28 results for Oxazoles+-+pharmacokinetics

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ArticlesPeer ReviewedFull Text
Delamanid for Multidrug-Resistant Pulmonary Tuberculosis
Author / Creator:Gler, Maria Tarcela ; Skripconoka, Vija ; Sanchez-Garavito, Epifanio ; Xiao, Heping ; Cabrera-Rivero, Jose L ; Vargas-Vasquez, Dante E ; Gao, Mengqiu ; Awad, Mohamed ; Park, Seung-Kyu ; Shim, Tae Sun ; Suh, Gee Young ; Danilovits, Manfred ; Ogata, Hideo ; Kurve, Anu ; Chang, Joon ; Suzuki, Katsuhiro ; Tupasi, Thelma ; Koh, Won-Jung ; Seaworth, Barbara ; Geiter, Lawrence J ; Wells, Charles D
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-06, Vol.366 (23), p.2151-2160
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First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours
Author / Creator:Ameratunga, Malaka ; Braña, Irene ; Bono, Petri ; Postel-Vinay, Sophie ; Plummer, Ruth ; Aspegren, John ; Korjamo, Timo ; Snapir, Amir ; de Bono, Johann S
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2020-12, Vol.123 (12), p.1730-1736
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Tedizolid: A Novel Oxazolidinone with Potent Activity Against Multidrug-Resistant Gram-Positive Pathogens
Author / Creator:Zhanel, George G. ; Love, Riley ; Adam, Heather ; Golden, Alyssa ; Zelenitsky, Sheryl ; Schweizer, Frank ; Gorityala, Bala ; Lagacé-Wiens, Philippe R. S. ; Rubinstein, Ethan ; Walkty, Andrew ; Gin, Alfred S. ; Gilmour, Matthew ; Hoban, Daryl J. ; Lynch, Joseph P. ; Karlowsky, James A.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2015-02, Vol.75 (3), p.253-270
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A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight
Author / Creator:Revel, F G ; Moreau, J-L ; Pouzet, B ; Mory, R ; Bradaia, A ; Buchy, D ; Metzler, V ; Chaboz, S ; Groebke Zbinden, K ; Galley, G ; Norcross, R D ; Tuerck, D ; Bruns, A ; Morairty, S R ; Kilduff, T S ; Wallace, T L ; Risterucci, C ; Wettstein, J G ; Hoener, M C
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2013-05, Vol.18 (5), p.543-556
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Safety, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both in adults with pulmonary tuberculosis: a randomised, active-controlled, o...
Author / Creator:Dawson, Rodney ; Diacon, Andreas H ; De Jager, Veronique ; Narunsky, Kim ; Moodley, V Mischka ; Stinson, Kelly W ; Liu, Yongge ; Zheng, Bo ; Hafkin, Jeffrey
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2025-04, Vol.25 (4), p.435-444
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Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach
Author / Creator:Ma, Ying ; Wang, Shu-Qing ; Xu, Wei-Ren ; Wang, Run-Ling ; Chou, Kuo-Chen
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-06, Vol.7 (6), p.e38546
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The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
Author / Creator:Patterson, Stephen ; Wyllie, Susan ; Norval, Suzanne ; Stojanovski, Laste ; Simeons, Frederick RC ; Auer, Jennifer L ; Osuna-Cabello, Maria ; Read, Kevin D ; Fairlamb, Alan H
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2016-05, Vol.5
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Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing
Author / Creator:Stillhart, Cordula ; Parrott, Neil J. ; Lindenberg, Marc ; Chalus, Pascal ; Bentley, Darren ; Szepes, Anikó
Publisher:New York: Springer US
Journal title:The AAPS journal, 2017-05, Vol.19 (3), p.827-836
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Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals
Author / Creator:Wilson, Robert ; Templeton, Alison ; Leemereise, Claudia ; Eames, Rhena ; Banham-Hall, Edward ; Hessel, Edith M ; Cahn, Anthony
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2019-06, Vol.41 (6), p.1214-1220
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Use of Pharmacokinetic/Pharmacodynamic Systems Analyses to Inform Dose Selection of Tedizolid Phosphate
Author / Creator:Lodise, Thomas P. ; Drusano, G. L.
Publisher:United States: OXFORD UNIVERSITY PRESS
Journal title:Clinical infectious diseases, 2014-01, Vol.58 (suppl_1), p.S28-S34
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Pharmacokinetics and Safety of Tedizolid after Single and Multiple Intravenous/Oral Sequential Administrations in Healthy Chinese Subjects
Author / Creator:Chen, Rui, MD ; Shen, Kai, MSc ; Chang, Xinying, MD ; Tanaka, Toshiaki, BSc ; Li, Li, MD ; Hu, Pei, MD
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2016-08, Vol.38 (8), p.1869-1879
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Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-dose Administration in Healthy Korean Male Subjects
Author / Creator:Kim, Yun ; Kim, Anhye ; Lee, SeungHwan ; Choi, Sung-Hak ; Lee, Dae Young ; Song, Ji-Su ; Lee, Howard ; Jang, In-Jin ; Yu, Kyung-Sang
Publisher:United States: Elsevier Inc
Journal title:Clinical therapeutics, 2017-09, Vol.39 (9), p.1849-1857
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Profile of delamanid for the treatment of multidrug-resistant tuberculosis
Author / Creator:Lynch, John ; Szumowski, John
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2015-01, Vol.9, p.677-682
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Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
Author / Creator:Kuruvilla, Finny G. ; Shamji, Alykhan F. ; Sternson, Scott M. ; Hergenrother, Paul J. ; Schreiber, Stuart L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2002-04, Vol.416 (6881), p.653-657
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Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections
Author / Creator:Ortiz-Covarrubias, Alejandro ; Fang, Edward ; Prokocimer, Philippe G. ; Flanagan, Shawn D. ; Zhu, Xu ; Cabré-Márquez, Jose Francisco ; Tanaka, Toshiaki ; Passarell, Julie ; Fiedler-Kelly, Jill ; Nannini, Esteban C.
Publisher:Brazil: Elsevier Editora Ltda
Journal title:The Brazilian journal of infectious diseases, 2016-03, Vol.20 (2), p.184-192
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Synthesis and Preclinical Evaluation of [18F]FCHC for Neuroimaging of Fatty Acid Amide Hydrolase
Author / Creator:Shoup, Timothy M. ; Bonab, Ali A. ; Wilson, Alan A. ; Vasdev, Neil
Publisher:Boston: Springer US
Journal title:Molecular imaging and biology, 2015-04, Vol.17 (2), p.257-263
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Quantitative determination of 2-amino-2-(2-(4′-(2-propyloxazol-4-yl)-[1,1′-biphenyl]-4-yl)ethyl)propane-1,3-diol and its active phosphorylated metabolite in rat blood by LC–MS/MS and application to PK...
Author / Creator:Zhao, Manman ; Mi, Jiaqi ; Li, Dan ; Liu, Xin ; Yang, Shuang ; Wang, Baolian ; Sheng, Li ; Wang, Xiaojian ; Jin, Jing ; Hu, Jinping ; Li, Yan
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2015-09, Vol.407 (24), p.7511-7516
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New Anti-Tuberculosis Drugs with Novel Mechanisms of Action
Author / Creator:Rivers, Emma ; Mancera, Ricardo
Publisher:Schiphol: Bentham Science Publishers Ltd
Journal title:Current medicinal chemistry, 2008-08, Vol.15 (19), p.1956-1967
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Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations
Author / Creator:Hu, Minhui ; Zheng, Chunlan ; Gao, Feng
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2016-01, Vol.10, p.3983-3994
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Metabolism, Excretion, and Pharmacokinetics of [14 C]-Radiolabeled Aleglitazar: A Phase I, Nonrandomized, Open-Label, Single-Center, Single-Dose Study in Healthy Male Volunteers
Author / Creator:Sturm, Stefan, PhD ; Seiberling, Michael, MD ; Weick, Idelette, MSc ; Paehler, Axel, PhD ; Funk, Christoph, PhD ; Ruf, Thorsten, MD
Publisher:Bridgewater, NJ: EM Inc USA
Journal title:Clinical therapeutics, 2012-02, Vol.34 (2), p.420-429
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Showing 1 to 20 of 28 results

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Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

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First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours

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Tedizolid: A Novel Oxazolidinone with Potent Activity Against Multidrug-Resistant Gram-Positive Pathogens

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A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight

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Safety, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both in adults with pulmonary tuberculosis: a randomised, active-controlled, o...

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Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach

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The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

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Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing

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Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals

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Use of Pharmacokinetic/Pharmacodynamic Systems Analyses to Inform Dose Selection of Tedizolid Phosphate

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Pharmacokinetics and Safety of Tedizolid after Single and Multiple Intravenous/Oral Sequential Administrations in Healthy Chinese Subjects

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Pharmacokinetics, Safety, and Tolerability of Tedizolid Phosphate After Single-dose Administration in Healthy Korean Male Subjects

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Profile of delamanid for the treatment of multidrug-resistant tuberculosis

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Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays

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Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections

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Synthesis and Preclinical Evaluation of [18F]FCHC for Neuroimaging of Fatty Acid Amide Hydrolase

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Quantitative determination of 2-amino-2-(2-(4′-(2-propyloxazol-4-yl)-[1,1′-biphenyl]-4-yl)ethyl)propane-1,3-diol and its active phosphorylated metabolite in rat blood by LC–MS/MS and application to PK...

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New Anti-Tuberculosis Drugs with Novel Mechanisms of Action

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Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations

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Metabolism, Excretion, and Pharmacokinetics of [14 C]-Radiolabeled Aleglitazar: A Phase I, Nonrandomized, Open-Label, Single-Center, Single-Dose Study in Healthy Male Volunteers

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